洋橄榄霉素
- 中文名称：
- 洋橄榄霉素
- 中文别名：
- ELAIOMYCIN
- 英文名称：
- 2-Butanol,4-methoxy-3-[(1E)-2-[(1Z)-1-octenyl]-2-oxidodiazenyl]-, (2S,3S)-
- 英文别名：
- ELAIOMYCIN;
(2S,3S)-4-Methoxy-3-[[(Z)-1-octenyl]-NNO-azoxy]-2-butanol;
DS-threo-4-methoxy-3-((Z)-oct-1-en-c-yl-ONN-azoxy)-butan-2-ol
- CAS No.：
- 23315-05-1
- 分 子 式：
-
C13H26N2O3
- 分 子 量：
- 258.41
- 精确分子量：
- 258.19400
- PSA：
- 70.57000
- InChI：
- The Key: BCPWSYQGYBTINM-ZABQTCLWSA-N3
- 安全术语：
- Poison by intravenous and subcutaneous routes. Questionable carcinogen with experimental tumorigenic data. Causes tumors of the brain. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
洋橄榄霉素 物化性质
- 密度：
- 1g/cm3
- 沸点：
- 385.3ºC at 760mmHg
- 闪点：
- 186.8ºC
- 折射率：
- 1.474
- 蒸汽压：
- 1.59E-07mmHg at 25°C
洋橄榄霉素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EL5075000
- CHEMICAL NAME :
- 2-Butanol, 4-methoxy-3-(1-octenyl-ONN-azoxy)-,
(E,Z)-(2S,3S)-
- CAS REGISTRY NUMBER :
- 23315-05-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C13-H26-N2-O3
- MOLECULAR WEIGHT :
- 258.41
- WISWESSER LINE NOTATION :
- QY1&Y1O1&NUNO&1U7
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >50 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema
Liver - hepatitis (hepatocellular necrosis), zonal
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 8,119-165,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67.
For publisher information, see JANTAJ. Volume(issue)/page/year: 10,224,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 44 mg/kg
- TOXIC EFFECTS :
- Behavioral - ataxia
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- ANTCAO Antibiotics and Chemotherapy (Washington, DC). (Washington, DC)
V.1-12, 1951-62. For publisher information, see CLMEA3.
Volume(issue)/page/year: 4,338,1954
** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
Kidney, Ureter, Bladder - Kidney tumors
- REFERENCE :
- NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
V.1- 1869- Volume(issue)/page/year: 221,765,1969
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Gastrointestinal - ulceration or bleeding from stomach
- REFERENCE :
- 29QKAZ "Toxins of Animal and Plant Origin, Proceedings International
Symposium, 2nd, 1970," de Vries, A., and E. Kochva, eds., 3 vols., New York,
Gordon and Breach Science Pub., 1971-73 Volume(issue)/page/year: 2,781,1972
