地塞米松异烟酸酯
- 中文名称：
- 地塞米松异烟酸酯
- 中文别名：
- 地塞米松异烟酸酯
- 英文名称：
- Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-[(4-pyridinylcarbonyl)oxy]-, (11b,16a)-
- 英文别名：
- Dexamethasone 21-isonicotinate;
Dexamethasone isonicotinate;
DEXAMETHASONE ISONICOTINATE
- CAS No.：
- 2265-64-7
- 分 子 式：
-
C28H32FNO6
- 分 子 量：
- 497.5552
- 精确分子量：
- 497.22100
- PSA：
- 113.79000
- EINECS：
- 218-866-5
- InChI：
- The Key: BQTXJHAJMDGOFI-YRCXVURZSA-N3
- 分子结构式：
-
- SDS：
- 查看
地塞米松异烟酸酯 物化性质
- 密度：
- 1.34 g/cm3
- 沸点：
- 676ºC at 760 mmHg
- 闪点：
- 362.6ºC
- 折射率：
- 1.608
- 蒸汽压：
- 3.39E-19mmHg at 25°C
地塞米松异烟酸酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU4060000
- CHEMICAL NAME :
- Pregna-1,4-diene-3,20-dione,
9-fluoro-11-beta,17,21-trihydroxy-16-alpha-methyl-,
21-isonicotinate
- CAS REGISTRY NUMBER :
- 2265-64-7
- LAST UPDATED :
- 199209
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C28-H32-F-N-O6
- MOLECULAR WEIGHT :
- 497.61
- WISWESSER LINE NOTATION :
- T6NJ DVO1V- FL E5 B666 OV AHTTT&J A1 BF CQ E1 FQ G1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3562 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 313 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3297 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3470 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 281 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3211 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University.
(Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143,
Japan) V.1- 1954- Volume(issue)/page/year: 20,769,1973
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 368 mg/m3/10M/44D-C
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,255,1974
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- DOSE :
- 4178 mg/m3/10M
- SEX/DURATION :
- male 44 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - testes, epididymis, sperm duct
Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
accessory glands
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,255,1974
推荐供应商
湖北信康医药化工有限公司
地塞米松异烟酸酯
- 联系人：张经理
- 电 话：027-59308705
- 手 机：18827031272
- Cas号：2265-64-7
- 包装：25kg纸板桶/编织袋/塑料桶
- 纯度：99%
- 价格：25.0元
