N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺
- 中文名称：
- N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺
- 中文别名：
- N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺
- 英文名称：
- Acetamide,N-[(3S,4R)-6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)-
- 英文别名：
- Y-27152,N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide;
Conantokin-R
- CAS No.：
- 127408-30-4
- 分 子 式：
-
C21H22N2O4
- 分 子 量：
- 366.41038
- 精确分子量：
- 366.15800
- PSA：
- 82.79000
- 分子结构式：
-
- SDS：
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N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺 物化性质
- 密度：
- 1.28g/cm3
- 沸点：
- 513.4ºC at 760mmHg
- 闪点：
- 264.3ºC
- 折射率：
- 1.617
- 蒸汽压：
- 2.29E-11mmHg at 25°C
N-(苄氧基)-n-((3s,4r)-6-氰基-3-羟基-2,2-二甲基苯并二氢吡喃-4-基)乙酰胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AB5956333
- CHEMICAL NAME :
- Acetamide,
N-(6-cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-be
nzopyran-4-yl)- N-(phenylmethoxy)-, (3S-trans)-
- CAS REGISTRY NUMBER :
- 127408-30-4
- LAST UPDATED :
- 199603
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C21-H22-N2-O4
- MOLECULAR WEIGHT :
- 366.45
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Cardiac - other changes
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the
Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year:
9,372,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Cardiac - other changes
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the
Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year:
9,372,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Cardiac - other changes
Vascular - BP lowering not characterized in autonomic section
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the
Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year:
9,372,1991
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 910 mg/kg/13W-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight
Vascular - BP lowering not characterized in autonomic section
Endocrine - changes in thymus weight
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the
Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year:
9,372,1991
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 27300 ug/kg/13W-I
- TOXIC EFFECTS :
- Cardiac - changes in heart weight
Vascular - BP lowering not characterized in autonomic section
- REFERENCE :
- CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the
Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year:
9,372,1991
