制备方法

由间硝基苯甲醛与乙酐缩合,用铝镍合金催化氢化还原,再经碘化与DMF缩合,成盐而得碘泊酸钠。

用途简介

该品为口服胆囊、胆管造影药。毒性低,极秒有副作用。在正常剂量范围内对肝、胆、骨肠病患者安全。显影效果好,不需经胆囊浓缩即可清楚地显示胆管与胆囊。对一些需要作快速胆囊造影的病例,在服药后2.5-3h,已可达到诊断所需要的显影程度。大鼠静脉注射LD50为430mg/kg,口服为3320mg/kg。

海关代码：

2925290090

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MW5160000

CHEMICAL NAME :

Hydrocinnamic acid, 3-(((dimethylamino)methylene)amino)-2,4,6-triiodo-

CAS REGISTRY NUMBER :

5587-89-3

LAST UPDATED :

199712

DATA ITEMS CITED :

2

MOLECULAR FORMULA :

C12-H13-I3-N2-O2

MOLECULAR WEIGHT :

597.97

WISWESSER LINE NOTATION :

QV2R BI DI FI CNU1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1030 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Blood - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - convulsions or effect on seizure threshold Blood - other changes

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 14,232,1969

中国海关编码：2925290090

概述：

2925290090 其他亚胺及其衍生物，以及它们的盐。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%