长春素
- 中文名称:
- 长春素
- 中文别名:
- 长春素;
长春罗新
- 英文名称:
- Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-
- 英文别名:
- LEUROSINE;
amotin;
4'-Deoxy-3',4'-epoxyvincaleucoblastine,9CI;
4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester;
(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;
Vinleurosine
- CAS No.:
- 23360-92-1
- 分 子 式:
-
C46H56N4O9
- 分 子 量:
- 808.9582
- 精确分子量:
- 808.40500
- PSA:
- 146.40000
- InChI:
- InChI=1/C46H56N4O9/c1-8-42-16-12-18-50-20-17-44(37(42)50)30-21-31(34(55-5)22-33(30)48(4)38(44)46(54,41(53)57-7)39(42)58-26(3)51)45(40(52)56-6)23-27-24-49(25-43(9-2)36(27)59-43)19-15-29-28-13-10-11-14-32(28)47-35(29)45/h10-14,16,21-22,27,36-39,47,54H,8-9,13
- 分子结构式:
-
- SDS:
- 查看
长春素 物化性质
- 密度:
- 1.39 g/cm3
- 熔点:
- 202-205℃
- 折射率:
- 1.677
长春素 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OH6370000
- CHEMICAL NAME :
- Leurosine
- CAS REGISTRY NUMBER :
- 23360-92-1
- BEILSTEIN REFERENCE NO. :
- 0079636
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C46-H56-N4-O9
- MOLECULAR WEIGHT :
- 809.06
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 15200 ug/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Gastrointestinal - hypermotility, diarrhea
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 105 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation
of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1-
1967- Volume(issue)/page/year: 18,667,1984
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Gastrointestinal - nausea or vomiting
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 60 mg/kg/30D-I
- TOXIC EFFECTS :
- Blood - changes in bone marrow (not otherwise specified)
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 30 mg/kg/15D-I
- TOXIC EFFECTS :
- Gastrointestinal - nausea or vomiting
Blood - changes in leukocyte (WBC) count
Related to Chronic Data - death
- REFERENCE :
- EKSODD Eksperimental'naya Onkologiya. Experimental Oncology. (V/O
Mezhdunarodnaya Kniga, 113095 Mosow, USSR) V.1- 1979-
Volume(issue)/page/year: 9(5),76,1987
长春素 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值(XlogP):无
2.氢键供体数量:2
3.氢键受体数量:12
4.可旋转化学键数量:10
5.互变异构体数量:无
6.拓扑分子极性表面积:146
7.重原子数量:59
8.表面电荷:0
9.复杂度:1750
10.同位素原子数量:0
11.确定原子立构中心数量:10
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1
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长春素
- 联系人:张经理
- 电 话:13070690626
- 手 机:13070690626
- Cas号:23360-92-1
- 包装:1kg
- 纯度:99%
- 价格:洽谈
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- 联系人:陆建雨
- 电 话:86-510-87509978
- 手 机:
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- 包装:2kg
- 纯度:98%-99%
- 价格:洽谈
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- 联系人:缪小姐
- 电 话:021-51320588-8035/8028/8026
- 手 机:13381604842
- Cas号:23360-92-1
- 包装:洽谈
- 纯度:
- 价格:洽谈