19-去甲睾酮亚硝基氨基甲酸酯
- 中文名称：
- 19-去甲睾酮亚硝基氨基甲酸酯
- 中文别名：
-
- 英文名称：
- Estr-4-en-3-one,17-[[[(2-chloroethyl)nitrosoamino]carbonyl]oxy]-, (17b)- (9CI)
- 英文别名：
- Estr-4-en-3-one, 17-[[[(2-chloroethyl)nitrosoamino]carbonyl]oxy]-, (17.β.)-;
19-nortestosterone nitrosocarbamate
- CAS No.：
- 54025-36-4
- 分 子 式：
-
C21H29ClN2O4
- 分 子 量：
- 408.97
- 精确分子量：
- 408.18200
- PSA：
- 76.04000
- 安全术语：
- Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Many N-nitroso compounds are carcinogens. When heated to decomposition it emits toxic fumes of Cl− and NOx. See also N-NITROSO COMPOUNDS and CARBAMATES.
- 分子结构式：
-
- SDS：
- 查看
19-去甲睾酮亚硝基氨基甲酸酯 物化性质
- 密度：
- 1.43g/cm3
- 沸点：
- 529.4ºC at 760mmHg
- 闪点：
- 274ºC
- 折射率：
- 1.661
19-去甲睾酮亚硝基氨基甲酸酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KG7962400
- CHEMICAL NAME :
- Estr-4-en-3-one,
17-((((2-chloroethyl)nitrosoamino)carbonyl)oxy)-,
(17-beta)-
- CAS REGISTRY NUMBER :
- 54025-36-4
- LAST UPDATED :
- 198602
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H29-Cl-N2-O4
- MOLECULAR WEIGHT :
- 408.97
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2190 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 155 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - gastritis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
Gastrointestinal - gastritis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
- TYPE OF TEST :
- LD10 - Lethal Dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1630 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - ulceration or bleeding from stomach
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 98 mg/kg
- TOXIC EFFECTS :
- Gastrointestinal - peritonitis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema
Gastrointestinal - gastritis
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59,
1945-86. For publisher information, see PHTOEH Volume(issue)/page/year:
49,290,1981
