[2-[(11S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]磷酸二氢酯
- 中文名称：
- [2-[(11S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]磷酸二氢酯
- 中文别名：
-
- 英文名称：
- Pregn-4-ene-3,20-dione,11,17-dihydroxy-21-(phosphonooxy)-, (11b)-
- 英文别名：
- cortisol phosphate;
Cortisol 21-monophosphate;
hydrocortone;
Hydrocortisone phosphate;
21-Hydrocortisonephosphoric acid;
Cortisol phosphate;
hydrocortisone 21-phosphate;
Hydrocortisone dihydrogen phosphate;
Cortisol 21-phosphate;
hydrocortisone sodium phosphate;
Cortisol 21-phosphoric acid;
Hydrocortisone 21-(dihydrogen phosphate);
Corphos
- CAS No.：
- 3863-59-0
- 分 子 式：
-
C21H31O8P
- 分 子 量：
- 442.49
- 精确分子量：
- 442.17600
- PSA：
- 151.17000
- EINECS：
- 223-382-2
- InChI：
- The Key: BGSOJVFOEQLVMH-OXPLYMOZSA-N3
- 安全术语：
- Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of POx. See also HYDROCORTISONE-21-ACETATE; HYDROCORTISONE-17-BUTYRATE; HYDROCORTISONE-17-BUTYRATE-21-PROPIONATE; HYDROCORTISONE SODIUM SUCCINATE.
- 分子结构式：
-
- SDS：
- 查看
[2-[(11S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]磷酸二氢酯 物化性质
- 密度：
- 1.42g/cm3
- 沸点：
- 669.9ºC at 760mmHg
- 闪点：
- 358.9ºC
- 折射率：
- 1.596
[2-[(11S,17R)-11,17-二羟基-10,13-二甲基-3-氧代-2,6,7,8,9,11,12,14,15,16-十氢-1H-环戊二烯并[a]菲-17-基]-2-氧代乙基]磷酸二氢酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GM9005000
- CHEMICAL NAME :
- Cortisol, 21-(dihydrogen phosphate)
- CAS REGISTRY NUMBER :
- 3863-59-0
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C21-H31-O8-P
- MOLECULAR WEIGHT :
- 442.49
- WISWESSER LINE NOTATION :
- L E5 B666 OV MUTJ A1 CQ E1 FV1OPQQO FQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 6 mg/kg
- SEX/DURATION :
- female 24-26 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - other effects to embryo
- REFERENCE :
- PEREBL Pediatric Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1967- Volume(issue)/page/year: 11,845,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 450 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 12,195,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 1800 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 12,195,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 900 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 12,195,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 8-16 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o
Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho,
Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher
information, see CGANE7. Volume(issue)/page/year: 15,238,1975
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X6661
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 7622 (estimated)
No. of Female Employees: 7177 (estimated)
