甲基4,8,9-三羟基-3-甲基-1-氧代-7-(1,5,9-三羟基-10a-甲氧羰基-6-甲基-8-氧代-6,7-二氢-5H-氧杂蒽-2-基)-3,4-二氢-2H-氧杂蒽-4a-羧酸酯
- 中文名称：
- 甲基4,8,9-三羟基-3-甲基-1-氧代-7-(1,5,9-三羟基-10a-甲氧羰基-6-甲基-8-氧代-6,7-二氢-5H-氧杂蒽-2-基)-3,4-二氢-2H-氧杂蒽-4a-羧酸酯
- 中文别名：
-
- 英文名称：
- [7,7'-Bi-4aH-xanthene]-4a,4'a-dicarboxylicacid,2,2',3,3',4,4',9,9'-octahydro-1,1',4,4',8,8'-hexahydroxy-3,3'-dimethyl-9,9'-dioxo-,4a,4'a-dimethyl ester, (3S,3'S,4R,4'R,4aR,4'aR)-
- 英文别名：
- (7,7'-Bi-4aH-xanthene)-4a,4'a-dicarboxylic acid, 2,2',3,3',4,4',9,9'-octahydro-1,1',4,4',8,8'-hexahydroxy-3,3'-dimethyl-9,9'-dioxo-, dimethyl ester, [3S-[3.α.,4.β.,4a.β.,7(3'r*,4's*,4'as*)]]-;
SECALONIC ACID D FROM PENICILLIUM*OXALICUM;
ergochrome EE;
secalonicacidd;
secalonic acid D1;
sad;
Secalonsaeure D
- CAS No.：
- 35287-69-5
- 分 子 式：
-
C32H30O14
- 分 子 量：
- 638.62
- 精确分子量：
- 638.16400
- PSA：
- 226.58000
- InChI：
- The Key: DRYDKQOPVBDZMQ-OCHURCMPSA-N3
- 危险品标志：
- 风险术语：
- 28
- 安全术语：
- Poison by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.
- 分子结构式：
-
- SDS：
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甲基4,8,9-三羟基-3-甲基-1-氧代-7-(1,5,9-三羟基-10a-甲氧羰基-6-甲基-8-氧代-6,7-二氢-5H-氧杂蒽-2-基)-3,4-二氢-2H-氧杂蒽-4a-羧酸酯 物化性质
- 密度：
- 1.67g/cm3
- 沸点：
- 846ºC at 760 mmHg
- 闪点：
- 273.7ºC
- 折射率：
- 1.725
甲基4,8,9-三羟基-3-甲基-1-氧代-7-(1,5,9-三羟基-10a-甲氧羰基-6-甲基-8-氧代-6,7-二氢-5H-氧杂蒽-2-基)-3,4-二氢-2H-氧杂蒽-4a-羧酸酯 安全信息
甲基4,8,9-三羟基-3-甲基-1-氧代-7-(1,5,9-三羟基-10a-甲氧羰基-6-甲基-8-氧代-6,7-二氢-5H-氧杂蒽-2-基)-3,4-二氢-2H-氧杂蒽-4a-羧酸酯 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EC2460000
- CHEMICAL NAME :
- (7,7'-Bi-4aH-xanthene)-4a,4'a-dicarboxylic acid,
2,2',3,3',4,4',9,9'-octahydro-1,1',4,4',8,
8'-hexahydroxy-3,3'-dimethyl-9,9'-dioxo-, dimethyl
ester, (3S-(3-alpha,4-beta,4a-beta, 7(3'R,4'S,4'aS)))
- CAS REGISTRY NUMBER :
- 35287-69-5
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 17
- MOLECULAR FORMULA :
- C32-H30-O14
- MOLECULAR WEIGHT :
- 638.62
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 22 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Liver - hepatitis (hepatocellular necrosis), zonal
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 26500 ug/kg
- TOXIC EFFECTS :
- Vascular - regional or general arteriolar or venous dilation
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - food intake (animal)
Skin and Appendages - hair
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 50 mg/kg/5D-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - chronic pulmonary edema
Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - respiratory system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - eye/ear
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - gastrointestinal
system
Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - craniofacial
(including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 13 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - physical
Reproductive - Effects on Newborn - delayed effects
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 150 mg/kg
- SEX/DURATION :
- lactating female 10 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - behavioral
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 45 mg/kg
- SEX/DURATION :
- female 7-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 25 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 30 mg/kg
- REFERENCE :
- JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 4(5-6),31,1980
