N-乙基-N-吡啶-3-基偶氮乙胺
- 中文名称：
- N-乙基-N-吡啶-3-基偶氮乙胺
- 中文别名：
- N-ethyl-N-(pyridin-3-yldiazenyl)ethanamine
- 英文名称：
- Pyridine,3-(3,3-diethyl-1-triazen-1-yl)-
- 英文别名：
- N-ethyl-N-(pyridin-3-yldiazenyl)ethanamine;
1-Pyridyl-3,3-diethyltriazene;
m-Pyridyl-diethyl-triazene
- CAS No.：
- 21600-43-1
- 分 子 式：
-
C9H14N4
- 分 子 量：
- 178.27
- 精确分子量：
- 178.12200
- PSA：
- 40.85000
- 安全术语：
- Poison by ingestion and subcutaneous routes. Questionable carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Human mutation data reported. A transplacental carcinogen. When heated to decomposition it emits toxic fumes of NOx.
- 分子结构式：
-
- SDS：
- 查看
N-乙基-N-吡啶-3-基偶氮乙胺 物化性质
- 密度：
- 1.03g/cm3
- 沸点：
- 260.4ºC at 760mmHg
- 闪点：
- 111.3ºC
- 折射率：
- 1.542
- 蒸汽压：
- 0.0123mmHg at 25°C
N-乙基-N-吡啶-3-基偶氮乙胺 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XY0495000
- CHEMICAL NAME :
- Triazene, 3,3-diethyl-1-(m-pyridyl)-
- CAS REGISTRY NUMBER :
- 21600-43-1
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C9-H14-N4
- MOLECULAR WEIGHT :
- 178.27
- WISWESSER LINE NOTATION :
- T6NJ CNUNN2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Liver - fatty liver degeneration
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 660 mg/kg/73W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Brain and Coverings - tumors
Cardiac - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 500 mg/kg/50W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria
Blood - leukemia
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 55 mg/kg
female 15 day(s) after conception
- TOXIC EFFECTS :
- Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - transplacental tumorigenesis
Brain and Coverings - tumors
- TYPE OF TEST :
- TD - Toxic dose (other than lowest)
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Peripheral Nerve and Sensation - peripheral nerve tumors
Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 10 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 167 mg/kg
- SEX/DURATION :
- female 15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Cytogenetic analysis
- TEST SYSTEM :
- Rodent - hamster Lung
- DOSE/DURATION :
- 100 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 88,197,1981
*** REVIEWS ***
TOXICOLOGY REVIEW
32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York,
Springer, 1975 Volume(issue)/page/year: -,49,1975
