萘夫西林钠
- 中文名称：
- 萘夫西林钠
- 中文别名：
- 萘夫西林钠;
乙氧萘青霉素
- 英文名称：
- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 6-[[(2-ethoxy-1-naphthalenyl)carbonyl]amino]-3,3-dimethyl-7-oxo-, sodiumsalt (1:1), (2S,5R,6R)-
- 英文别名：
- nafcillin sodium;
Benzenamine,N-ethyl-3-(trifluoromethyl);
NAFCILLIN SODIUM SALT;
N-ethyl-3-trifluoromethyl-aniline;
Sodium nafcillin;
N-Ethyl-3-(trifluormethyl)-anilin;
Nafcillin sodium
- CAS No.：
- 985-16-0
- 分 子 式：
-
C21H22N2O5S.Na
- 分 子 量：
- 437.50
- 精确分子量：
- 436.10700
- PSA：
- 124.07000
- EINECS：
- 213-574-4
- InChI：
- InChI=1/C21H22N2O5S.Na/c1-4-28-13-10-9-11-7-5-6-8-12(11)14(13)17(24)22-15-18(25)23-16(20(26)27)21(2,3)29-19(15)23;/h5-10,15-16,19H,4H2,1-3H3,(H,22,24)(H,26,27);/q;+1/t15-,16+,19-;/m1./s13
- 风险术语：
- 42/43
- 安全术语：
- Moderately toxic by intraperitoneal and intravenous routes. Human systemic effects by intravenous route: interstitial nephritis (kidney damage), proteinuria (protein in the urine), hematuria (blood in the urine), leukopenia (reduced number of leukocytes in the blood), rosinophilia, agranulocytosis (reduced levels of granulocytes) and liver changes. When heated to decomposition it emits very toxic fumes of NOx, SOx, and Na2O.
- 分子结构式：
-
- SDS：
- 查看
萘夫西林钠 物化性质
- 密度：
- 1.42g/cm3
- 沸点：
- 714.1ºC at 760mmHg
- 闪点：
- 385.7ºC
萘夫西林钠 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XI0175000
- CHEMICAL NAME :
- 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
6-(2-ethoxy-1-naphthamido)- 3,3-dimethyl-7-oxo-,
monosodium salt
- CAS REGISTRY NUMBER :
- 985-16-0
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C21-H22-N2-O5-S.Na
- MOLECULAR WEIGHT :
- 437.50
- WISWESSER LINE NOTATION :
- T45 ANV ESTJ F1 F1 GVQ CMV- BL66J CO2 &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 3200 mg/kg/20D-I
- TOXIC EFFECTS :
- Gastrointestinal - hypermotility, diarrhea
Liver - jaundice, cholestatic
Skin and Appendages - dermatitis, other (after systemic exposure)
- REFERENCE :
- AJGAAR American Journal of Gastroenterology. (American College of
Gastroenterology, Inc., 428 E. Preston St., Baltimore, MD 21202) V.21-
1954- Volume(issue)/page/year: 88,1960,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 4560 mg/kg/19D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
232,1150,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 450 mg/kg/3D
- TOXIC EFFECTS :
- Liver - other changes
Blood - leukopenia
Blood - eosinophilia
- REFERENCE :
- AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St.,
Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
Volume(issue)/page/year: 135,52,1981
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 3100 mg/kg/18D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - interstitial nephritis
Kidney, Ureter, Bladder - proteinuria
Kidney, Ureter, Bladder - hematuria
- REFERENCE :
- JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
244,2609,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 429 mg/kg/23D-I
- TOXIC EFFECTS :
- Blood - agranulocytosis
- REFERENCE :
- JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N.
Dearborn St., Chicago, IL 60610) V.1- 1883- Volume(issue)/page/year:
232,1152,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 37,69,1974
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 633 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
6,220,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 1266 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
6,220,1964
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 2955 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
6,220,1964
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3706
No. of Facilities: 288 (estimated)
No. of Industries: 1
No. of Occupations: 8
No. of Employees: 14341 (estimated)
No. of Female Employees: 11125 (estimated)
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萘夫西林酸
- 联系人：张经理
- 电 话：+86-531-62318870/89702887
- 手 机：13969111034
- Cas号：985-16-0
- 包装：洽谈
- 纯度：
- 价格：洽谈
