制备方法

可在油田钻井作业中和建筑灌浆作业中用作堵水剂,亦可在丙烯酸树脂和粘合剂合成中用作交联剂。用作分离氨基酸的重要材料及光敏尼龙或光敏塑料的重要原料。用作光敏尼龙和光敏塑料原料、建筑灌浆材料,也用于照相、印刷、制版等。 用作堵水灌浆材料;亦可用作交联剂,在光敏材料、吸水材料、光缆涂层、生物技术等方面也有重要应用。

合成制备方法

用途简介

用途

可在油田钻井作业中和建筑灌浆作业中用作堵水剂，亦可在丙烯酸树脂和粘合剂合成中用作交联剂。用作分离氨基酸的重要材料及光敏尼龙或光敏塑料的重要原料。用作光敏尼龙和光敏塑料原料、建筑灌浆材料，也用于照相、印刷、制版等。

用作堵水灌浆材料；亦可用作交联剂，在光敏材料、吸水材料、光缆涂层、生物技术等方面也有重要应用。

包装等级：

III

风险类别：

6.1(b)

海关代码：

2924199090

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R20/21/22

安全说明：

S22-S36/37

RTECS号：

AS3678000

危险标志：

Xn:Harmful

CHEMICAL IDENTIFICATION

RTECS NUMBER :

AS3678000

CHEMICAL NAME :

Acrylamide, N,N'-methylenebis-

CAS REGISTRY NUMBER :

110-26-9

BEILSTEIN REFERENCE NO. :

1706297

LAST UPDATED :

199710

DATA ITEMS CITED :

18

MOLECULAR FORMULA :

C7-H10-N2-O2

MOLECULAR WEIGHT :

154.19

WISWESSER LINE NOTATION :

1U1VM1MV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

390 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - tremor Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>41 ppm/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

380 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>41 ppm/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

LC - Lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

>41 ppm/6H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

3206 mg/kg/8W-I

TOXIC EFFECTS :

Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

3208 mg/kg

SEX/DURATION :

male 16 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

360 mg/kg

SEX/DURATION :

female 6-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Maternal Effects - parturition Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

50 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

225 mg/kg

SEX/DURATION :

male 1 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

Sex chromosome loss and nondisjunction

TYPE OF TEST :

Dominant lethal test

MUTATION DATA

TEST SYSTEM :

Rodent - mouse

DOSE/DURATION :

450 mg/kg/5D (Continuous)

REFERENCE :

MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 229,161,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83963 No. of Facilities: 199 (estimated) No. of Industries: 4 No. of Occupations: 5 No. of Employees: 2098 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83963 No. of Facilities: 10 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 66 (estimated) No. of Female Employees: 35 (estimated)

毒理学数据：

1、    急性毒性：大鼠经口LD5O：390mg/kg

大鼠吸入LC：>41ppm/6H

小鼠经口LD5O：380mg/kg

小鼠吸入LC：>41ppm/6H

豚鼠吸入LC：>41ppm/6H

2、    其他多剂量数据：小鼠经口TDLO：3206mg/kg/8W-I

3、    生殖毒性：雄性小鼠交配前经口TDLO：3208mg/kg，持续时间16天

雌性小鼠受精后经口TDLO：360mg/kg，持续时间6-17天

              雄性小鼠交配前经口TDLO：50mg/kg，持续时间1天

雄性小鼠交配前腹腔TDLO：225mg/kg，持续时间1天

4、    致突变：沙门氏菌突变：1mg/plate

             果蝇性染色体缺失和不分离：600ppm

             小鼠显性致死实验：225mg/kg

             小鼠可遗传转位测试：450mg/kg/5D

生态数据：

该物质对水体有的危害，不要让该产品接触地下水，水道和污水处理系统。

中国海关编码：2924199090

概述：

2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途, 包装

摘要/Summary：

2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

分子结构数据

1、   摩尔折射率：41.71

2、   摩尔体积（cm³/mol）：146.1

3、   等张比容（90.2K）：354.6

4、   表面张力（dyne/cm）：34.7

5、   极化率（10^-24cm³）：16.32

计算化学数据

1.疏水参数计算参考值（XlogP）:0.1

2.氢键供体数量:2

3.氢键受体数量:2

4.可旋转化学键数量:4

5.互变异构体数量:3

6.拓扑分子极性表面积58.2

7.重原子数量:11

8.表面电荷:0

9.复杂度:167

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  N
• 
  N'-亚甲基双丙烯酰胺Raman光谱
• 
  N
• 
  N'-亚甲基双丙烯酰胺质谱(MS)