纳必龙
- 中文名称：
- 纳必龙
- 中文别名：
- 纳比隆;
反式-6,6-二甲基-3-(1,1-二甲基庚基)-1-羟基-6,6a,7,8,10,10a-六氢-9H-二苯并[b,d]吡喃-9-酮;
纳必龙
- 英文名称：
- 9H-Dibenzo[b,d]pyran-9-one,3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hydroxy-6,6-dimethyl-,(6aR,10aR)-rel-
- 英文别名：
- (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-7,8,10,10a-tetrahydro-6aH-benzo[c]chromen-9-one;
Nabilonum;
Cesamet;
Cesamet (TN);
Nabilon;
Nabilona;
Nabilone (USAN/INN);
Nabilone
- CAS No.：
- 51022-71-0
- 分 子 式：
-
C24H36O3
- 分 子 量：
- 372.55
- 精确分子量：
- 372.26600
- PSA：
- 46.53000
- EINECS：
- 200-835-2
- InChI：
- The Key: GECBBEABIDMGGL-MUMRKEEXSA-N3
- 风险术语：
- 22
- 分子结构式：
-
- SDS：
- 查看
纳必龙 物化性质
- 外观与性状：
- 白色固体
- 密度：
- 1.029 g/cm3
- 熔点：
- 155-156ºC
- 沸点：
- 457.4ºC at 760mmHg
- 闪点：
- 145.4ºC
- 折射率：
- 1.516
纳必龙 安全信息
- 危险类别码：
- R22
- 安全说明：
- 36/37/39-45
- 危险标志：
- Xn: Harmful;
纳必龙 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- HP8756000
- CHEMICAL NAME :
- 9H-Dibenzo(b,d)pyran-9-one,
3-(1,1-dimethylheptyl)-6,6a,7,8,10,10a-hexahydro-1-hy
droxy- 6,6-dimethyl-, trans-(+-)-
- CAS REGISTRY NUMBER :
- 51022-71-0
- LAST UPDATED :
- 199403
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C24-H36-O3
- MOLECULAR WEIGHT :
- 372.60
- WISWESSER LINE NOTATION :
- T B666 DV IOTT&J H1 H1 LX6&1&1 NQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >1000 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Behavioral - ataxia
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1000 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - Straub tail
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >5 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >1 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Behavioral - food intake (animal)
Behavioral - ataxia
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- >10 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - food intake (animal)
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- >1 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Behavioral - ataxia
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 205 mg/kg/29W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
Related to Chronic Data - death
- REFERENCE :
- FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
9,185,1987
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 348 mg/kg
- SEX/DURATION :
- female 14-22 day(s) after conception
lactating female 20 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
48,A120,1979
