磺胺对甲氧嘧啶
- 中文名称：
- 磺胺对甲氧嘧啶
- 中文别名：
- 普鲁卡因胺;
4-氨基-N-[2-(二乙基氨基)乙基]苯甲酰胺;
4-氨基-n-(2-二乙基氨基乙基)苯甲酰胺
- 英文名称：
- Benzamide,4-amino-N-[2-(diethylamino)ethyl]-
- 英文别名：
- procainamide;
4-Amino-N-(2-diethylaminoethyl)benzamide;
4-amino-N-[2-(diethylamino)ethyl]benzamide
- CAS No.：
- 51-06-9
- 分 子 式：
-
C13H21N3O
- 分 子 量：
- 235.37
- 精确分子量：
- 235.16800
- PSA：
- 58.36000
- InChI：
- The Key: REQCZEXYDRLIBE-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
磺胺对甲氧嘧啶 物化性质
- 密度：
- 1.06
- 沸点：
- 421.8ºC at 760mmHg
- 闪点：
- 208.9ºC
磺胺对甲氧嘧啶 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- CV2275000
- CHEMICAL NAME :
- Benzamide, p-amino-N-(2-(diethylamino)ethyl)-
- CAS REGISTRY NUMBER :
- 51-06-9
- BEILSTEIN REFERENCE NO. :
- 2214285
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C13-H21-N3-O
- MOLECULAR WEIGHT :
- 235.37
- WISWESSER LINE NOTATION :
- ZR DVM2N2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 8579 mg/kg/43W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - fibrosing alveolitis
- REFERENCE :
- AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New
York, NY 10022) V.1- 1946- Volume(issue)/page/year: 76,146,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
- REFERENCE :
- AJCDAG American Journal of Cardiology. (Technical Pub. Co., 875 Third Ave.,
New York, NY 10022) V.1- 1958- Volume(issue)/page/year: 57,340,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 1826 mg/kg/13W-I
- TOXIC EFFECTS :
- Cardiac - other changes
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:
83,798,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 2280 mg/kg/22W
- TOXIC EFFECTS :
- Musculoskeletal - joints
- REFERENCE :
- BHJUAV British Heart Journal. (British Medical Journal, Box 560B,
Kennebunkport, ME 04046) V.1- 1939- Volume(issue)/page/year: 34,284,1972
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 583 mg/kg/12D-C
- TOXIC EFFECTS :
- Cardiac - arrhythmias (including changes in conduction)
- REFERENCE :
- AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial
Dr., St. Louis, MO 63146) V.1- 1925- Volume(issue)/page/year:
109,375,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1950 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press
Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929-
Volume(issue)/page/year: 42,3628,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RPTOAN Russian Pharmacology and Toxicology (English Translation).
Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey,
UK) V.30- 1967- Volume(issue)/page/year: 33,292,1970
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see
PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2-
1939- Volume(issue)/page/year: 54(3),32,1991
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 525 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CCCCAK Collection of Czechoslovak Chemical Communications. (Academic Press
Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1929-
Volume(issue)/page/year: 42,3628,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 178 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year:
37,551,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 720 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year:
37,551,1985
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 49 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year:
37,551,1985
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 2210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
21,253,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 170 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year:
32,833,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001,
00-068 Warsaw 1, Poland) V.25- 1973- Volume(issue)/page/year:
32,833,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 280 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
Italy) V.8-43 1953-88 For publisher information, see FRMCE8
Volume(issue)/page/year: 12,77,1957
*** REVIEWS ***
TOXICOLOGY REVIEW
INTEAG Internist. (Springer-Verlag New York, Inc., Service Center, 44 Hartz
Way, Secaucus, NJ 07094) V.1- 1960- Volume(issue)/page/year: 15,7,1974
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4172
No. of Facilities: 66 (estimated)
No. of Industries: 2
No. of Occupations: 5
No. of Employees: 8032 (estimated)
No. of Female Employees: 7252 (estimated)
磺胺对甲氧嘧啶 海关数据
中国海关编码：2924299090
- 概述：
- 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 包装
- 摘要/Summary：
- 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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磺胺对甲氧嘧啶
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磺胺对甲氧嘧啶
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