萘二磺酸乙乳胆铵; 双醋萘磺胆碱; 双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐; 2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐
- 中文名称：
- 萘二磺酸乙乳胆铵; 双醋萘磺胆碱; 双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐; 2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐
- 中文别名：
- 萘二磺酸乙乳胆铵;
2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐;
双醋萘磺;
双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐
- 英文名称：
- Aclatonium napadisilate
- 英文别名：
- 2-(2-acetyloxypropanoyloxy)ethyl-trimethylazanium,naphthalene-1,5-disulfonate;
TM 723;
Aciatonium napadisilat;
Aclatonium napadisilat;
aclatonium napadisilate;
Abovis;
Aciatonium napadisylate
- CAS No.：
- 55077-30-0
- 分 子 式：
-
C30H44N2O14S2
- 分 子 量：
- 720.81
- 精确分子量：
- 722.23900
- PSA：
- 236.36000
- 分子结构式：
-
- SDS：
- 查看
萘二磺酸乙乳胆铵; 双醋萘磺胆碱; 双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐; 2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐 制备方法及用途
制备方法
将双(胆碱)-萘-1,5二磺酸盐悬浮于乙腈中,再加入乳酸酐二醋酸酯,加热混合物回流3小时。所得产物冷却析出结晶。过滤得产品。
用途简介
胆碱能药。
萘二磺酸乙乳胆铵; 双醋萘磺胆碱; 双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐; 2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐 物化性质
- 外观与性状：
- 白色结晶粉末
- 熔点：
- 189-191ºC
- 存储条件/存储方法：
- 库房通风低温干燥
萘二磺酸乙乳胆铵; 双醋萘磺胆碱; 双(乙酰氧基-甲基醋酸三甲胺乙酯)-萘-1,5-二磺酸盐; 2-[2-(乙酰氧基)-1-氧丙氧基]-N,N,N-三甲基乙铵-1,5-萘二磺酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KH2570000
- CAS REGISTRY NUMBER :
- 55077-30-0
- LAST UPDATED :
- 199703
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C10-H20-N-O4.1/2C10-H6-O6-S2
- MOLECULAR WEIGHT :
- 361.42
- WISWESSER LINE NOTATION :
- 1VOY1&VO2K1&1&1 2 &L66J BSWO GSWO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >13889 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 12,1204,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 986 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 13,497,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 46 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 13,497,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 15 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #3903137
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15
Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-
Volume(issue)/page/year: 99,1245,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 826 mg/kg
- TOXIC EFFECTS :
- Behavioral - tremor
Lungs, Thorax, or Respiration - dyspnea
Kidney, Ureter, Bladder - urine volume increased
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 13,497,1977
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 12,1204,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation
Gastrointestinal - changes in structure or function of salivary glands
Skin and Appendages - hair
- REFERENCE :
- YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka
Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-
Volume(issue)/page/year: 23,2171,1981
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 312 gm/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in bladder weight
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - phosphatases
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,907,1979
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 312 gm/kg/26W-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,93,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 gm/kg
- SEX/DURATION :
- male 9 week(s) pre-mating
female 2 week(s) pre-mating - 6 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 18,923,1979
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