磷酸三甲酚酯,1330-78-5，生产厂家，价格-洛克化工网移动版

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制备方法及用途

物化性质

安全信息

毒理性

MSDS

海关数据

结构与计算化学

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磷酸三甲酚酯

中文名称：: 磷酸三甲酚酯

中文别名：: 磷酸三甲苯酯;
磷酸三甲酚酯;
三甲苯基磷酸酯;
三甲苯磷酸酯

英文名称：: Phosphoric acid,tris(methylphenyl) ester

英文别名：: Phosphoric Acid Tricresyl Ester;
Tritolyl phosphate;
Tricresyl phosphate;
Phosphoric Acid Tritolyl Ester

CAS No.：: 1330-78-5

分子式：: C₂₁H₂₁O₄P

分子量：: 368.37

精确分子量：: 1104.35000

PSA：: 163.71000

MDL：: MFCD02102116

EINECS：: 215-548-8

InChI：: InChI=1/3C21H21O4P/c1-16-4-10-19(11-5-16)23-26(22,24-20-12-6-17(2)7-13-20)25-21-14-8-18(3)9-15-21;1-16-10-4-7-13-19(16)23-26(22,24-20-14-8-5-11-17(20)2)25-21-15-9-6-12-18(21)3;1-16-11-13-19(14-12-16)23-26(22,24-20-9-6-7-17(2)15-20)25-21-10-5-4-8-18(21)3/h3

危险品标志：: T:
N:

风险术语：: R39/23/24/25;R51/53;

安全术语：: S20/21;S28A;S45;S61;

分子结构式：

SDS：: 查看

磷酸三甲酚酯制备方法及用途

制备方法

(一)固载杂多酸盐催化合成法 (1)固载杂多酸盐催化剂的制备取一定量的TiC l4,加入12%氨水调至pH值为7-8,沉淀,经抽滤和洗涤至用0.1mol/LAgNO3检查Cl离子为止,烘干。将上述原料与一定量的经过预热处理的H4S iW12O40·ηH2O反应1.5h,整个过程溶液保持近沸状态,缓慢蒸除水分,烘干,得到组成为TiSiW12O40/Tio2的催化剂。 (2)合成在反应器中加入定量混合甲酚,制备好的TiSiW12O40/Tio2催化剂(原料总量的1.0%),搅拌,加热至60℃开始滴加三氯氧磷,约1h内加完。升温至100℃继续反应,控制湿度在100-120℃待基本无HCI放出,反应约8h。过滤出催化剂,然后减压蒸馏去前馏分得产品,产率约85.5%。 (二)三氯化磷间接法(冷法) 混合甲酚和三氯化磷在15-20℃下反应,生成亚磷酸三甲苯酯;然后在60-70℃通入氯气,生成二氯代亚磷酸三甲苯酯;再于50℃下进行水解,而生成磷酸三甲苯酯。最后经水洗、中和、蒸发脱水和减压蒸馏,截取340-360℃kPa)馏分作为成品。精制方法:异构体分离困难,一般仅用减压蒸馏除去异构体以外的杂质。

合成制备方法

（一）固载杂多酸盐催化合成法

（1）固载杂多酸盐催化剂的制备取一定量的TiC l4，加入12%氨水调至pH值为7-8，沉淀，经抽滤和洗涤至用0.1mol/LAgNO3检查Cl离子为止，烘干。将上述原料与一定量的经过预热处理的H4S iW12O40·ηＨ2O反应1.5h，整个过程溶液保持近沸状态，缓慢蒸除水分，烘干，得到组成为TiSiW12O40/Tio2的催化剂。

（2）合成在反应器中加入定量混合甲酚，制备好的TiSiW12O40/Tio2催化剂（原料总量的1.0%），搅拌，加热至60℃开始滴加三氯氧磷，约1h内加完。升温至100℃继续反应，控制湿度在100-120℃待基本无HCI放出，反应约8h。过滤出催化剂，然后减压蒸馏去前馏分得产品，产率约85.5%。

（二）三氯化磷间接法（冷法）混合甲酚和三氯化磷在15-20℃下反应，生成亚磷酸三甲苯酯；然后在60-70℃通入氯气，生成二氯代亚磷酸三甲苯酯；再于50℃下进行水解，而生成磷酸三甲苯酯。最后经水洗、中和、蒸发脱水和减压蒸馏，截取340-360℃kPa)馏分作为成品。

精制方法：异构体分离困难，一般仅用减压蒸馏除去异构体以外的杂质。

用途简介

热固性聚酯，丙烯酸类树脂，腈类树脂。

用途

1.本品为阻燃性增塑剂。与许多纤维素树脂、乙烯基树脂、聚苯乙烯、合成橡胶相容，尤其与聚氯乙烯相容性极好，且可作为相容性差的助剂媒介，改善与树脂的相容性。本品有很好的相容性、阻燃性、防霉性、耐磨性、耐污染性、耐候性、耐辐射性和电气性能。本品用于油漆，可增加漆膜的柔韧性。本品还用于合成橡胶及黏胶纤维作为增塑剂。

2.用作难燃性增塑剂，用于聚氯乙烯制品如电缆料、人造革、运输带、薄板、地板料等。还用于氯丁橡胶和粘胶纤维。此外，磷酸三甲苯酯还用作防水剂、润滑剂和硝酸纤维素的耐燃性溶剂。

3.用作塑料增塑剂、喷漆增塑剂。^[24]

磷酸三甲酚酯毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TD0175000

CHEMICAL NAME :: Phosphoric acid, tritolyl ester

CAS REGISTRY NUMBER :: 1330-78-5

LAST UPDATED :: 199806

DATA ITEMS CITED :: 35

MOLECULAR FORMULA :: C21-H21-O4-P

MOLECULAR WEIGHT :: 368.39

WISWESSER LINE NOTATION :: 1R XOPO&OR X1&OR X1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/29/1964

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1131,1986 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 70 mg/kg/14D

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - changes in motor activity (specific assay) Behavioral - muscle weakness

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,88,1981

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 1800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,585,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015) Volume(issue)/page/year: 2,96,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982 Volume(issue)/page/year: -,114,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: 29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968 Volume(issue)/page/year: -,339,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968 Volume(issue)/page/year: -,339,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Behavioral - ataxia

REFERENCE :: TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 1000(Sp Iss 1),141,198

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZWAE "Practical Toxicology of Plastics," Lefaux, R., Cleveland, OH, Chemical Rubber Co., 1968 Volume(issue)/page/year: -,339,1968

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - hypermotility, diarrhea Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534886

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK) Volume(issue)/page/year: 3,93,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 41,291,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 20300 mg/kg/16D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Endocrine - changes in thymus weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-433,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 8,107,1974

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 252 mg/kg/6W-C

TOXIC EFFECTS :: Immunological Including Allergic - decrease in cellular immune response Immunological Including Allergic - decrease in humoral immune response

REFERENCE :: BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- Volume(issue)/page/year: 49,312,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24 gm/kg/60D-I

TOXIC EFFECTS :: Endocrine - other changes

REFERENCE :: TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 22,341,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 52 gm/kg/13W-I

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 5,108,1985

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10220 mg/kg/16D-I

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Liver - changes in liver weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-433,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 2100 mg/kg/6W-I

TOXIC EFFECTS :: Behavioral - tremor Behavioral - excitement Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,585,1957 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4550 mg/kg

SEX/DURATION :: male 13 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 6,292,1986

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 13200 mg/kg

SEX/DURATION :: male 66 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 46,321,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 16 gm/kg

SEX/DURATION :: male 66 day(s) pre-mating female 24 day(s) pre-mating - 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 46,321,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1750 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,344,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 4464 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating female 7 day(s) pre-mating - 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,344,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7250 mg/kg

SEX/DURATION :: female 7 day(s) pre-mating female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - live birth index (measured after birth)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,344,1988

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2250 mg/kg

SEX/DURATION :: male 7 day(s) pre-mating female 7 day(s) pre-mating - 22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - germ cell effects (in offspring)

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 10,344,1988 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82880 No. of Facilities: 15911 (estimated) No. of Industries: 131 No. of Occupations: 79 No. of Employees: 146408 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82880 No. of Facilities: 15728 (estimated) No. of Industries: 132 No. of Occupations: 95 No. of Employees: 239503 (estimated) No. of Female Employees: 66405 (estimated)

毒理学数据：

1.急性毒性^[13] LD50：5190mg/kg（大鼠经口）

2.刺激性^[14]

家兔经皮：500mg，轻度刺激（开放性刺激试验）。

家兔经眼：500mg（24h），轻度刺激。

3.其他^[15] 大鼠经口最低中毒剂量（TDLo）：3150mg/kg（雄性，21d），对睾丸、输精管、附睾有影响。

生态数据：

1.生态毒性^[16] LC50：0.26mg/L（96h）（虹鳟鱼，动态）；0.15mg/L（96h）（蓝鳃太阳鱼，动态）

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

4.生物富集性^[17] BCF：165（黑头呆鱼，接触时间32d，动态）；700（斑马鱼，接触时间14d，动态）；3700（食蚊鱼）

磷酸三甲酚酯 MSDS

国标编号:	61112
ＣＡＳ:	1330-78-5
中文名称:	磷酸三甲苯酯
英文名称:	tricresyl phosphate；tritolyl phosphate
别名:	磷酸三甲酚酯；增塑剂TCP
分子式:	C₂₁H₂₁O₄P；(CH₃C₆H₄O)₃PO
分子量:	368.36
熔点:	-33℃ 沸点：420℃
密度:	相对密度(水=1)1.16；
蒸汽压:	225℃
溶解性:	不溶于水，溶于醇、苯等多有机溶剂
稳定性:	稳定
外观与性状:	无色或淡黄色的透明油状液体
危险标记:	14(有毒品)
用途:	用作塑料增塑剂、喷漆增塑剂

2.对环境的影响:
一、健康危害

侵入途径：吸入、食入、经皮吸收。
健康危害：本品引起中毒性神经病，对体内假性胆碱酯酶有抑制作用，但不抑制真性胆碱酯酶。
急性中毒：大量口服先出现恶心、呕吐、腹泻，后出现肌肉疼痛，继之迅即出现肢体发麻和肌无力，可引起足、腕下垂。损害以运动神经为主。重者可有咽喉肌肉、眼肌和呼吸麻痹，可因呼吸麻痹而致死。亦可经皮肤、呼吸道吸收。
慢性中毒：长期小量接触邻位磷酸三甲苯酯，可出现与纪行中毒相同的神经系统损害。

二、毒理学资料及环境行为

急性毒性：LD505190mg/kg(大鼠经口)
生殖毒性：大鼠经口最低中毒剂量(TDL0)3150 mg/kg(雄性，21天)，对睾丸、输精管、附睾有影响。

危险特性：可燃。受热分解产生剧毒的氧化磷烟气。与氧化剂能民生强烈反应。
燃烧(分解)产物：一氧化碳、二氧化碳、氧化磷、磷烷。

3.现场应急监测方法:
　

4.实验室监测方法:
气相色谱法《水质分析》张曼平等译
紫外分光光度法《空气中有害物质的测定方法》(第二版)杭士平编
空气中样品的测定：样品用过滤器收集，用乙醚洗脱，再用气相色谱法分析(NIOSH法)

5.环境标准:
前苏联车间空气中有害物质的最高容许浓度 0.1mg/m3
前苏联(1975)水体中有害物质最高允许浓度0.005mg/L

6.应急处理处置方法:
一、泄漏应急处理

迅速撤离泄漏污染区人员至安全区，并进行隔离，严格限制出入。切断火源。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土、干燥石灰或苏打水混合。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器中，回收或运至废物处理场所处置。

二、防护措施

呼吸系统防护：可能接触其蒸气时，应该佩戴自吸过滤式防毒面具(半面罩)。紧急事态抢救或撤离时，佩戴循环式氧气呼吸器。
眼睛防护：戴化学安全防护眼镜。
身体防护：穿胶布防毒服。
手防护：戴防化学品手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，彻底清洗。单独存放被毒物污染的衣服，洗后备用。实行就业前和定期的体检。

三、急救措施

皮肤接触：脱去被污染的衣着，用肥皂水和清水彻底冲洗皮肤，就医。
眼睛接触：提起眼睑，用流动清水或生理盐水冲洗，就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐。就医。

灭火方法：消防人员须佩戴防毒面具、穿全身消防服。灭火剂：干粉、二氧化碳、砂土。

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磷酸三甲酚酯 分子结构与计算化学数据

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计算化学数据

磷酸三甲酚酯 表征图谱

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磷酸三甲酚酯制备方法及用途

磷酸三甲酚酯物化性质

磷酸三甲酚酯安全信息

磷酸三甲酚酯毒理性

磷酸三甲酚酯海关数据

磷酸三甲酚酯分子结构与计算化学数据

磷酸三甲酚酯表征图谱