二甲替嗪
- 中文名称：
- 二甲替嗪
- 中文别名：
- 二甲替嗪
- 英文名称：
- 10H-Phenothiazine-2-sulfonamide,10-[2-(dimethylamino)propyl]-N,N-dimethyl-
- 英文别名：
- 10-[2-(dimethylamino)propyl]-N,N-dimethylphenothiazine-2-sulfonamide;
dimethothiazine;
FONAZINE;
Dimetiotazine;
Dimethodin;
10-(2-dimethylamino-propyl)-10H-phenothiazine-2-sulfonic acid dimethylamide;
Dimetotiazinum [INN-Latin];
N,N-Dimethyl-10-(2-dimethylaminopropyl)-phenothiazin-2-sulfonamide;
Dimetotiazine;
Dimetotiazine [INN:BAN];
Bayer 1483;
Dimetotiazina [INN-Spanish];
Dimetiotazin;
Dimethothiazin
- CAS No.：
- 7456-24-8
- 分 子 式：
-
C19H25N3O2S2
- 分 子 量：
- 391.557
- 精确分子量：
- 391.13900
- PSA：
- 77.54000
- EINECS：
- 231-229-6
- InChI：
- The Key: VWNWVCJGUMZDIU-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
二甲替嗪 物化性质
- 密度：
- 1.235g/cm3
- 沸点：
- 533.7ºC at 760 mmHg
- 闪点：
- 276.6ºC
- 折射率：
- 1.612
二甲替嗪 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- SP5250000
- CHEMICAL NAME :
- Phenothiazine-2-sulfonamide,
10-(2-(dimethylamino)propyl)-N,N-dimethyl-
- CAS REGISTRY NUMBER :
- 7456-24-8
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C19-H25-N3-O2-S2
- MOLECULAR WEIGHT :
- 391.59
- WISWESSER LINE NOTATION :
- T C666 BN ISJ B1Y1&N1&1 ESWN1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 740 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 475 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 159,70,1966
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4-
1898- Volume(issue)/page/year: 159,70,1966
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 600 mg/kg
- SEX/DURATION :
- female 9-14 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,381,1970
