卡前列素氨基丁三醇; (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇
- 中文名称：
- 卡前列素氨基丁三醇; (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇
- 中文别名：
- 卡前列素氨基丁三醇;
(Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇;
卡前列腺氨丁三醇
- 英文名称：
- Carboprost tromethamine
- 英文别名：
- carboprost tromethamine;
Carboprost tromethamine
- CAS No.：
- 58551-69-2
- 分 子 式：
-
C21H36O5.C4H11NO3
- 分 子 量：
- 489.64
- 精确分子量：
- 489.33000
- PSA：
- 184.70000
- 分子结构式：
-
- SDS：
- 查看
卡前列素氨基丁三醇; (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇 物化性质
- 密度：
- 1.153g/cm3
- 沸点：
- 536.6ºC at 760 mmHg
- 闪点：
- 292.4ºC
卡前列素氨基丁三醇; (Z)-7-[(3R,5S)-3,5-二羟基-2-[(E,3S)-3-羟基-3-甲基辛-1-烯基]环戊基]庚-5-烯酸氨基丁三醇 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UK8026000
- CAS REGISTRY NUMBER :
- 58551-69-2
- LAST UPDATED :
- 198910
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C21-H36-O5.C4-H11-N-O3
- MOLECULAR WEIGHT :
- 489.73
- WISWESSER LINE NOTATION :
- L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 25100 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 131 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 30 ug/kg
- SEX/DURATION :
- female 14 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - abortion
- REFERENCE :
- CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1-
1970- Volume(issue)/page/year: 11,533,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 87 ug/kg
- SEX/DURATION :
- female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 87 ug/kg
- SEX/DURATION :
- female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - parturition
Reproductive - Fertility - abortion
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 6 mg/kg
- SEX/DURATION :
- male 3 day(s) pre-mating
female 3 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 300 ug/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
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