硫喷妥钠,71-73-8，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

海关数据

结构与计算化学

硫喷妥钠

中文名称：: 硫喷妥钠

中文别名：: 硫喷妥钠;
潘托撤戊硫巴比妥钠;
5-乙基-5-(1-甲丁基)-2-硫代巴比土酸钠

英文名称：: 4,6(1H,5H)-Pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, sodium salt (1:1)

英文别名：: thiopental sodium;
trapanal;
intravalsodium;
5-ethyl-5-(1-methyl-butyl)-6-oxo-2-thioxo-1,2,5,6-tetrahydro-pyrimidin-4-olate sodium salt;
5-ethyl-5-(1-methylbutyl)-2-thiobarbituric acid sodium salt;
leopental;
5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate acid sodium salt;
farmotal;
Thiopentemal;
hypnostan;
(+/-)-THIOPENTAL SODIUM SALT/SODIUM CARBONATE;
thiothalsodium;
rac-thiopentone sodium;
ravonal;
thionembutal;
nesdonal sodium

CAS No.：: 71-73-8

分子式：: C₁₁H₁₈N₂O₂S.Na

分子量：: 246.32

精确分子量：: 264.09100

PSA：: 83.83000

InChI：: The Key: AWLILQARPMWUHA-UHFFFAOYSA-L3

危险品标志：: T

风险术语：: R25

安全术语：: S36-45

分子结构式：

SDS：: 查看

硫喷妥钠毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CQ6475000

CHEMICAL NAME :: Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium salt

CAS REGISTRY NUMBER :: 71-73-8

LAST UPDATED :: 199606

DATA ITEMS CITED :: 23

MOLECULAR FORMULA :: C11-H18-N2-O2-S.Na

MOLECULAR WEIGHT :: 265.36

WISWESSER LINE NOTATION :: T6VMYMV FHJ CUS FY3&1 F2 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Human

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease Behavioral - general anesthetic

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 46,395,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 107 mg/kg

TOXIC EFFECTS :: Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Lungs, Thorax, or Respiration - acute pulmonary edema

REFERENCE :: CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 2,75,1969

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraarterial

SPECIES OBSERVED :: Human

DOSE/DURATION :: 7 mg/kg

TOXIC EFFECTS :: Vascular - acute arterial occlusion Vascular - thrombosis distant from injection site

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,571,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 117 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,432,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 28410 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 29,509,1940

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 43600 ug/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,317,1956

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Rectal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression Nutritional and Gross Metabolic - body temperature decrease Behavioral - general anesthetic

REFERENCE :: AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957- Volume(issue)/page/year: 46,395,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 208 mg/kg

TOXIC EFFECTS :: Behavioral - general anesthetic

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 115,432,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 115 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,70,1974

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 57 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 105,221,1956

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 150 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 60,125,1937

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 36 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see AACRAT. Volume(issue)/page/year: 29,89,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 32500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 82,212,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,457,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CRAAA7 Current Researches in Anesthesia and Analgesia. (Cleveland, OH) V.1-35, 1922-56. For publisher information, see AACRAT. Volume(issue)/page/year: 29,89,1950

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 57500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ANESAV Anesthesiology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1940- Volume(issue)/page/year: 8,589,1947 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 750 mg/kg/30D-I

TOXIC EFFECTS :: Liver - fatty liver degeneration Related to Chronic Data - death

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 116,317,1956 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 50 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: OFAJAE Okajimas Folia Anatomica Japonica. (Keio Univ., School of Medicine, Dept. of Anatomy, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.14- 1936- Volume(issue)/page/year: 43,219,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 75 mg/kg

SEX/DURATION :: female 11 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: OFAJAE Okajimas Folia Anatomica Japonica. (Keio Univ., School of Medicine, Dept. of Anatomy, 35 Shinano-machi, Shinjuku-ku, Tokyo 160, Japan) V.14- 1936- Volume(issue)/page/year: 43,219,1967

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 432 mg/kg

SEX/DURATION :: female 3-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 43,225,1969 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1306 No. of Facilities: 158 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2048 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1306 No. of Facilities: 335 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 5619 (estimated) No. of Female Employees: 4042 (estimated)

湖北云镁科技有限公司

硫喷妥钠

联系人：方经理
电话：027-59206672
手机：18327059871

Cas号：71-73-8
包装：267kg,1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：1.0元 - 267.0元

湖北诺纳科技有限公司

硫喷妥钠

联系人：张经理
电话：027-59209883
手机：17386169806

Cas号：71-73-8
包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
纯度：99%
价格：1.0元 - 25.0元

淄博航宇生物科技发展有限公司

硫喷妥钠

联系人：张经理
电话：15666366704
手机：15666366704

Cas号：71-73-8
包装：100kg
纯度：99%
价格：洽谈

天津士兰科技有限公司

硫喷妥

联系人：赵平
电话：022-26358246
手机：15722085757

Cas号：71-73-8
包装：洽谈
纯度：
价格：洽谈

广东利玮医药有限公司

硫喷妥钠

联系人：陈凡
电话：020-87687760
手机：

Cas号：71-73-8
包装：洽谈
纯度：
价格：洽谈

硫喷妥钠

硫喷妥钠制备方法及用途

制备方法

合成制备方法

用途简介

用途

硫喷妥钠物化性质

硫喷妥钠安全信息

硫喷妥钠毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硫喷妥钠海关数据

中国海关编码：2933599090

硫喷妥钠分子结构与计算化学数据

计算化学数据

推荐供应商

湖北云镁科技有限公司

硫喷妥钠

湖北诺纳科技有限公司

硫喷妥钠

淄博航宇生物科技发展有限公司

硫喷妥钠

天津士兰科技有限公司

硫喷妥

广东利玮医药有限公司

硫喷妥钠

硫喷妥钠

硫喷妥钠 制备方法及用途

制备方法

合成制备方法

用途简介

用途

硫喷妥钠 物化性质

硫喷妥钠 安全信息

硫喷妥钠 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硫喷妥钠 海关数据

中国海关编码：2933599090

硫喷妥钠 分子结构与计算化学数据

计算化学数据

推荐供应商

湖北云镁科技有限公司

硫喷妥钠

湖北诺纳科技有限公司

硫喷妥钠

淄博航宇生物科技发展有限公司

硫喷妥钠

天津士兰科技有限公司

硫喷妥

广东利玮医药有限公司

硫喷妥钠

硫喷妥钠制备方法及用途

硫喷妥钠物化性质

硫喷妥钠安全信息

硫喷妥钠毒理性

硫喷妥钠海关数据

硫喷妥钠分子结构与计算化学数据