磺庚甲泼尼龙
- 中文名称：
- 磺庚甲泼尼龙
- 中文别名：
- 磺庚甲泼尼龙
- 英文名称：
- Pregna-1,4-diene-3,20-dione,11,17-dihydroxy-6-methyl-21-[[8-[methyl(2-sulfoethyl)amino]-1,8-dioxooctyl]oxy]-,sodium salt (1:1)
- 英文别名：
- sodium,2-[[8-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-8-oxooctanoyl]-methylamino]ethanesulfonate;
METHYLPREDNISOLONE SULEPTANATE;
suleptanate de methylprednisolone [French];
Methylprednisoloni suleptanas [Latin];
Medrosol;
Methylprednisolone suleptanate sodium salt;
Promedrol
- CAS No.：
- 90350-40-6
- 分 子 式：
-
C33H49NO10S.Na
- 分 子 量：
- 673.79
- 精确分子量：
- 673.29000
- PSA：
- 186.79000
- 分子结构式：
-
- SDS：
- 查看
磺庚甲泼尼龙 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TU3822100
- CHEMICAL NAME :
- Pregan-1,4-diene-3,20-dione,
11,71-dihydroxy-6-methyl-21-((8-(methyl(2-sulfoethyl)
amino)- 1,8-dioxooctyl)oxy)-, monosodium salt,
(6-alpha,11-beta)-
- CAS REGISTRY NUMBER :
- 90350-40-6
- LAST UPDATED :
- 199803
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C33-H48-N-O10-S.Na
- MOLECULAR WEIGHT :
- 673.87
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 756 mg/kg
- SEX/DURATION :
- male 9 week(s) pre-mating
female 2 week(s) pre-mating - 7 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - other effects on male
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,2911,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 495 mg/kg
- SEX/DURATION :
- female 7 week(s) pre-mating
lactating female 3 week(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,2911,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 297 mg/kg
- SEX/DURATION :
- female 7-17 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Effects on Newborn - behavioral
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,2937,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 23400 mg/kg
- SEX/DURATION :
- multigeneration
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - delayed effects
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,2959,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 11700 ug/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,2979,1993
*** REVIEWS ***
TOXICOLOGY REVIEW
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
22,833,1997
磺庚甲泼尼龙 分子结构与计算化学数据
计算化学数据
1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:2
3.氢键受体数量:10
4.可旋转化学键数量:14
5.互变异构体数量:6
6.拓扑分子极性表面积:187
7.重原子数量:46
8.表面电荷:0
9.复杂度:1360
10.同位素原子数量:0
11.确定原子立构中心数量:8
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:2
