莫维普利钙; (2R)-1-[(2R)-3-[2-(环己基甲酰氨基)丙酰硫]-2-甲基丙酰基]吡咯烷-2-甲酸钙盐
- 中文名称：
- 莫维普利钙; (2R)-1-[(2R)-3-[2-(环己基甲酰氨基)丙酰硫]-2-甲基丙酰基]吡咯烷-2-甲酸钙盐
- 中文别名：
- 莫维普利钙;
(2R)-1-[(2R)-3-[2-(环己基甲酰氨基)丙酰硫]-2-甲基丙酰基]吡咯烷-2-甲酸钙盐
- 英文名称：
- L-Proline,N-(cyclohexylcarbonyl)-D-alanyl-(2S)-3-mercapto-2-methylpropanoyl-, calciumsalt (2:1)
- 英文别名：
- Moveltipril calcium;
MC 838;
altiopril calcium
- CAS No.：
- 85921-53-5
- 分 子 式：
-
C19H30N2O5S.1/2Ca
- 分 子 量：
- 835.10
- 精确分子量：
- 834.32200
- PSA：
- 236.16000
- 分子结构式：
-
- SDS：
- 查看
莫维普利钙; (2R)-1-[(2R)-3-[2-(环己基甲酰氨基)丙酰硫]-2-甲基丙酰基]吡咯烷-2-甲酸钙盐 物化性质
- 密度：
- 1.248g/cm3
- 沸点：
- 658.9ºC at 760mmHg
- 闪点：
- 352.3ºC
莫维普利钙; (2R)-1-[(2R)-3-[2-(环己基甲酰氨基)丙酰硫]-2-甲基丙酰基]吡咯烷-2-甲酸钙盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TW3620000
- CAS REGISTRY NUMBER :
- 85921-53-5
- LAST UPDATED :
- 199106
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C38-H58-N4-O10-S2.Ca
- MOLECULAR WEIGHT :
- 835.20
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- >6 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TJEMAO Tohoku Journal of Experimental Medicine. (Maruzen Co. Ltd., Export
Dept., P.O. Box 5050, Tokyo Int., 100-31 Tokyo, Japan) V.1- 1920-
Volume(issue)/page/year: 152,363,1987
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 gm/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
female 2 week(s) pre-mating
female 1 week(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 18,3301,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 2500 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 18,3335,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 625 mg/kg
- SEX/DURATION :
- female 17-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 18,3335,1990
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 130 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - other effects
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 18,3325,1990
