盐酸哌罗匹隆; N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐
- 中文名称：
- 盐酸哌罗匹隆; N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐
- 中文别名：
- 盐酸哌罗匹隆;
N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐
- 英文名称：
- Perospirone hydrochloride
- 英文别名：
- Perospirone Hydrochloride Trihydrate;
Perospirone hydrochloride
- CAS No.：
- 129273-38-7
- 分 子 式：
-
C23H30N4O2S.HCl
- 分 子 量：
- 463.04
- 精确分子量：
- 462.18600
- PSA：
- 84.99000
- InChI：
- InChI=1/C24H32N4O2S.ClH/c29-23-20-9-3-4-10-21(20)24(30)28(23)12-6-5-11-26-13-15-27(16-14-26)22-19-8-2-1-7-18(19)17-31-25-22;/h1-2,7-8,20-21H,3-6,9-17H2;1H/t20-,21+;3
- 危险品标志：
-
- 风险术语：
-
- 安全术语：
-
- 分子结构式：
-
- SDS：
- 查看
盐酸哌罗匹隆; N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐 物化性质
- 外观与性状：
- 白色固体
- 熔点：
- 95-970ºC
- 沸点：
- 667.4ºC at 760 mmHg
- 闪点：
- 357.4ºC
盐酸哌罗匹隆; N-{4-[4-(1,2-苯并噻唑-3-基)-1-哌嗪]丁基}环己-1,2-二甲酰亚胺盐酸盐 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- NR3397915
- CHEMICAL NAME :
- 1H-Isoindole-1,3(2H)-dione,
2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl
)hexahydro-, monohydrochloride, cis-
- CAS REGISTRY NUMBER :
- 129273-38-7
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 7
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 870 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Lungs, Thorax, or Respiration - dyspnea
Skin and Appendages - hair
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,177,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,177,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 660 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,177,1997
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,201,1997
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 9125 mg/kg/1Y-I
- TOXIC EFFECTS :
- Liver - other changes
Endocrine - changes in adrenal weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,309,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 2275 mg/kg/13W-I
- TOXIC EFFECTS :
- Behavioral - tremor
Endocrine - changes in thymus weight
Blood - changes in leukocyte (WBC) count
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,201,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 1820 mg/kg/52W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - somnolence (general depressed activity)
Behavioral - tremor
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 31,309,1997
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- 联系人：方经理
- 电 话：027-59206672
- 手 机：18327059871
- Cas号：129273-38-7
- 包装：267kg,1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
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- 联系人：张经理
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- 包装：1kg铝箔袋/氟化瓶,10kg铝听/纸箱,25kg纸板桶/编织袋/塑料桶
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上海吉至生化科技有限公司
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- 联系人：Shirley张
- 电 话：021-57520831
- 手 机：18116052675
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- 包装：5mgea
- 纯度：分析对照品,HPLC≥98%
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- 联系人：Yuki
- 电 话：021-61845781
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- 纯度：HPLC≥98%
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