制备方法

1、将PrSP(O)Cl2与粉状P2S5于130℃加热3h，得PrSP(S)Cl2。将它溶于苯中，在0～5℃用乙醇和三乙胺处理得～167℃PrS(EtO)O(S)Cl。再与2，4-二氯苯酚和炭碳酸钾在甲乙酮中反应，回流3h，得丙硫磷。反应也可在装有搅拌器、温度计和回流冷凝器的反应器中进行，将五硫化二磷，2，4-二氯苯酚、催化剂及有机溶剂，在较低温度下反应2～3h，然后加入缚酸剂和溴丙烷，升温再反应2h，反应毕，冷却过滤，水洗至中性，减压脱溶得丙溴磷。

合成制备方法

1、   将PrSP(O)Cl2与粉状P2S5于130℃加热3h，得PrSP(S)Cl2。将它溶于苯中，在0～5℃用乙醇和三乙胺处理得～167℃PrS(EtO)O(S)Cl。再与2，4-二氯苯酚和炭碳酸钾在甲乙酮中反应，回流3h，得丙硫磷。
反应也可在装有搅拌器、温度计和回流冷凝器的反应器中进行，将五硫化二磷，2，4-二氯苯酚、催化剂及有机溶剂，在较低温度下反应2～3h，然后加入缚酸剂和溴丙烷，升温再反应2h，反应毕，冷却过滤，水洗至中性，减压脱溶得丙溴磷。

用途简介

1、不对称有机磷杀虫剂，具有广谱的生物活性，无内吸性。对鳞翅目幼虫有高效，尤其对按基甲酸酯和其他有机磷杀虫剂产生交抗的蚜类、蓟马、粉蚧、卷叶虫类和蠕虫类有良好效果，对多抗性品系的家蝇有较好的杀灭活性，对蚊子和孑孓同样高效，对鞘翅目害虫有效，对叶蝉科、盲蝽科和瓢虫科害虫弱效。对地下害虫的幼虫期有明显的活性，用于防治金针虫、地老虎和白蚁之类的重要地下害虫也有希望。乳油通常对水1000倍喷雾，蔬菜安全间隔期阴为21d，柑橘为45d。

用途

1、   不对称有机磷杀虫剂，具有广谱的生物活性，无内吸性。对鳞翅目幼虫有高效，尤其对按基甲酸酯和其他有机磷杀虫剂产生交抗的蚜类、蓟马、粉蚧、卷叶虫类和蠕虫类有良好效果，对多抗性品系的家蝇有较好的杀灭活性，对蚊子和孑孓同样高效，对鞘翅目害虫有效，对叶蝉科、盲蝽科和瓢虫科害虫弱效。对地下害虫的幼虫期有明显的活性，用于防治金针虫、地老虎和白蚁之类的重要地下害虫也有希望。乳油通常对水1000倍喷雾，蔬菜安全间隔期阴为21d，柑橘为45d。

海关代码：

2930909062

危险类别码：

R22;R50/53

安全说明：

S60-S61

RTECS号：

TD5680000

安全标志：

S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。

危险标志：

Xn: Harmful;N: Dangerous for the environment;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TD5680000

CHEMICAL NAME :

Phosphorodithioic acid, O-(2,4-dichlorophenyl) O-ethyl S-propyl ester

CAS REGISTRY NUMBER :

34643-46-4

LAST UPDATED :

199710

DATA ITEMS CITED :

19

MOLECULAR FORMULA :

C11-H15-Cl2-O2-P-S2

MOLECULAR WEIGHT :

345.25

WISWESSER LINE NOTATION :

GR CG DOPS&S3&O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

875 mg/kg

TOXIC EFFECTS :

Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(5),92,1988

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>271 mg/m3/4H

TOXIC EFFECTS :

Peripheral Nerve and Sensation - sensory change involving peripheral nerve Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,641,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KONODE Kongetsu no Noyaku. Agricultural Chemicals Monthly. (Kagoku Kogyo Nipposha, 3-19-16 Shibaura, Minato-ku, Tokyo 108, Japan) V.1- 1957- Volume(issue)/page/year: 20,94,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>3 gm/kg

TOXIC EFFECTS :

Peripheral Nerve and Sensation - sensory change involving peripheral nerve Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - dyspnea

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 15,641,1990

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

570 mg/kg

TOXIC EFFECTS :

Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(5),92,1988

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

KONODE Kongetsu no Noyaku. Agricultural Chemicals Monthly. (Kagoku Kogyo Nipposha, 3-19-16 Shibaura, Minato-ku, Tokyo 108, Japan) V.1- 1957- Volume(issue)/page/year: 20,94,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1250 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (26),14,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

750 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (26),14,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - chicken

DOSE/DURATION :

100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (26),14,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - quail

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (26),14,1976

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

2 gm/kg

TOXIC EFFECTS :

Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(5),92,1988

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Bird - domestic

DOSE/DURATION :

100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (26),14,1976 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1592 mg/kg/26W-I

TOXIC EFFECTS :

Brain and Coverings - recordings from specific areas of CNS Blood - changes in erythrocyte (RBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 53(5),92,1988

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

218 mg/kg/13W-C

TOXIC EFFECTS :

Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 5,641,1990

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

12200 ug/m3/4H/17W-I

TOXIC EFFECTS :

Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

REFERENCE :

GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 34(1),45,1990

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1092 mg/kg/2Y-C

TOXIC EFFECTS :

Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 5,641,1990

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

273 mg/kg/13W-C

TOXIC EFFECTS :

Liver - changes in liver weight Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 5,641,1990

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1378 mg/kg/82W-C

TOXIC EFFECTS :

Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :

NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976- Volume(issue)/page/year: 5,641,1990

毒理学数据：

日本东京断科令科学校测定，雄大鼠急性经日LDS。为1730mg /kg ,雌大鼠1800mg /kg，雄小鼠940mg /kg ,雌小鼠960mg /kg，雄兔750mg /kg，雄猫} SOOmg /kg。雄大鼠急性经皮LD50为4170mg /kg ,雌大鼠41 OOmg /kg，雄小鼠1650mg /kg ,雌小鼠1600mg /kg o皮下注射LDS})大鼠} 3000mg /kg，小鼠1250 - 1550mg/kgo Elbcrfcld毒物研究所测定雄大鼠急性经日LD50为925mg /kg ,雌大鼠947mg /kg，雄小鼠1036mg /kg ,雌小鼠1051 mg

中国海关编码：2930909062

概述：

2930909062 丙溴磷、田乐磷、特丁硫磷等〔包括硫丙磷、地虫硫膦、乙硫磷、丙硫磷、甲基乙拌磷〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:30.0%

申报要素：

品名, 成分含量, 用途

监管条件：

S.进出口农药登记证明

摘要/Summary：

2930909062 s-((tert-butylthio)methyl) o,o-diethyl phosphorodithioate

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:4

4.可旋转化学键数量:7

5.互变异构体数量:无

6.拓扑分子极性表面积75.8

7.重原子数量:18

8.表面电荷:0

9.复杂度:294

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:1

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1

• 
  丙硫磷质谱(MS)