夸西泮,36735-22-5，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

结构与计算化学

下游产品

夸西泮

中文名称：: 夸西泮

中文别名：: 夸西泮;
氟硫安定;
7-氯-5-(2-氟苯基)-1,3-二氢-1-(2,2,2-三氟乙基)-2H-1,4-苯并二氮杂卓-2-硫酮;
7-氯-5-(2-氟苯基)-1-(2,2,2-三氟乙基)-3H-1,4-苯并二氮杂卓-2-硫酮

英文名称：: 2H-1,4-Benzodiazepine-2-thione,7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-

英文别名：: 7-chloro-5-(2-fluorophenyl)-1-(2,2,2-trifluoroethyl)-3H-1,4-benzodiazepine-2-thione;
Oniria;
Cetrane;
Doral;
Quazepamum;
quazepam;
Quazapam;
Dormalin;
Selepam;
Prosedar;
Quazium

CAS No.：: 36735-22-5

分子式：: C₁₇H₁₁ClF₄N₂S

分子量：: 386.79

精确分子量：: 386.02700

PSA：: 47.69000

EINECS：: 253-179-4

InChI：: InChI=1/C17H11ClF4N2S/c18-10-5-6-14-12(7-10)16(11-3-1-2-4-13(11)19)23-8-15(25)24(14)9-17(20,21)22/h1-7H,8-9H23

危险品标志：

风险术语：

安全术语：

分子结构式：

SDS：: 查看

夸西泮物化性质

密度：
0.984 g/mL at 25 °C(lit.)

熔点：
22°C

沸点：
223 °C10 mm Hg(lit.)

闪点：
193 °F

折射率：
n20/D 1.459(lit.)

蒸汽密度：
>1 (vs air)

其它信息：

1.性状：从二氯甲烷-己烷结晶。
2.熔点：137.5～139℃。

夸西泮安全信息

包装等级：
III

风险类别：
6.1(b)

夸西泮毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE9710000

CHEMICAL NAME :
2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1- (2,2,2-trifluoroethyl)-

CAS REGISTRY NUMBER :
36735-22-5

BEILSTEIN REFERENCE NO. :
0901084

LAST UPDATED :
199612

DATA ITEMS CITED :
10

MOLECULAR FORMULA :
C17-H11-Cl-F4-N2-S

MOLECULAR WEIGHT :
386.81
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
>5 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
2749 mg/kg

TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
5 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,1456,1982

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
845 mg/kg

TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
LD - Lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
>1 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
LD - Lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
>1 gm/kg

TOXIC EFFECTS :
Behavioral - ataxia Behavioral - analgesia

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 32,1456,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Primate - monkey

DOSE/DURATION :
18 gm/kg/52W-I

TOXIC EFFECTS :
Liver - fatty liver degeneration Liver - changes in liver weight Related to Chronic Data - death

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - hamster

DOSE/DURATION :
14 gm/kg/4W-I

TOXIC EFFECTS :
Liver - changes in liver weight Related to Chronic Data - changes in ovarian weight

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987 ** REPRODUCTIVE DATA **

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
90 mg/kg

SEX/DURATION :
female 13-21 day(s) after conception lactating female 21 day(s) post-birth

TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
520 mg/kg

SEX/DURATION :
female 6-18 day(s) after conception

TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain)

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 37,906,1987

毒理学数据：

急性毒性LD₅₀小鼠(mg/kg)：＞1370静脉注射，＞5000口服。急性毒性LD₅₀雄、雌小鼠，雄、雌大鼠(mg/kg)：845，921，3072，2749腹腔注射。

夸西泮分子结构与计算化学数据

分子结构数据

1、摩尔折射率：92.19
2、摩尔体积（cm³/mol）：271.1
3、等张比容（90.2K）：673.4
4、表面张力（dyne/cm）：38.0
5、极化率（10-24cm3）：36.54

计算化学数据

1.疏水参数计算参考值（XlogP）:无
2.氢键供体数量:0
3.氢键受体数量:6
4.可旋转化学键数量:2
5.互变异构体数量:2
6.拓扑分子极性表面积47.7
7.重原子数量:25
8.表面电荷:0
9.复杂度:539
10.同位素原子数量:0
11.确定原子立构中心数量:0
12.不确定原子立构中心数量:0
13.确定化学键立构中心数量:0
14.不确定化学键立构中心数量:0
15.共价键单元数量:1

夸西泮下游产品

7-氯-5-(2-氟苯基)-1,3-二氢-1-(2,2,2-三氟乙基)-2H-1,4-苯并二氮杂卓-2-酮

推荐供应商

山东默派生物科技有限公司

夸西泮
联系人：张经理
电  话：13070690626
手  机：13070690626
Cas号：36735-22-5
包装：1kg
纯度：99%
价格：洽谈
湖北恩星生物科技有限公司

夸西泮
联系人：邵经理
电  话：16621771607
手  机：16621771607
Cas号：36735-22-5
包装：500kg,400kg,300kg,200kg,100kg
纯度：
价格：64.0元 - 100.0元

夸西泮

夸西泮制备方法及用途

制备方法

合成制备方法

用途简介

用途

夸西泮物化性质

夸西泮安全信息

夸西泮毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

夸西泮分子结构与计算化学数据

分子结构数据

计算化学数据

夸西泮下游产品

推荐供应商

山东默派生物科技有限公司

夸西泮

湖北恩星生物科技有限公司

夸西泮

夸西泮

夸西泮 制备方法及用途