噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸
- 中文名称:
- 噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸
- 中文别名:
- 噻洛芬酸;
异噻酮布洛芬;
2-(5-苄氧基噻吩-2-基)丙酸;
2-(5-苯甲氧基噻吩-2-基)丙酸;
2-[5-(苯甲酰基)-2-噻吩基]丙酸
- 英文名称:
- 2-Thiopheneacetic acid,5-benzoyl-a-methyl-
- 英文别名:
- Tiaprofenic Acid;
2-(5-Benzoylthiophen-2-yl)propanoic acid;
Tiaprofenic acid;
2-(5-Benzoylthiophen-2-yl)propionic Acid
- CAS No.:
- 33005-95-7
- 分 子 式:
-
C14H12O3S
- 分 子 量:
- 260.31
- 精确分子量:
- 260.05100
- PSA:
- 82.61000
- EINECS:
- 251-329-3
- InChI:
- The Key: GUHPRPJDBZHYCJ-UHFFFAOYSA-N3
- 分子结构式:
-
- SDS:
- 查看
噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸 制备方法及用途
制备方法
主要用于治疗风湿性关节炎、关节僵硬、术后疼痛等。
用途简介
噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸 物化性质
- 密度:
- 1.29 g/cm3
- 沸点:
- 450.3ºC at 760 mmHg
- 闪点:
- 226.1ºC
- 折射率:
- 1.612
噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XM7580000
- CHEMICAL NAME :
- 2-Thiopheneacetic acid, 5-benzoyl-alpha-methyl-
- CAS REGISTRY NUMBER :
- 33005-95-7
- BEILSTEIN REFERENCE NO. :
- 1380662
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 16
- MOLECULAR FORMULA :
- C14-H12-O3-S
- MOLECULAR WEIGHT :
- 260.32
- WISWESSER LINE NOTATION :
- T5SJ BY1&VQ EVR
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 168 mg/kg/14D-I
- TOXIC EFFECTS :
- Vascular - shock
Lungs, Thorax, or Respiration - other changes
Gastrointestinal - ulceration or bleeding from small intestine
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 158,647,1993
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 672 mg/kg/7W-I
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - anorexia (human)
Liver - other changes
- REFERENCE :
- LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 1,803,1986
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 16 mg/kg/2D-I
- TOXIC EFFECTS :
- Behavioral - wakefulness
Behavioral - hallucinations, distorted perceptions
Behavioral - excitement
- REFERENCE :
- CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB
8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911- Volume(issue)/page/year:
137,1022,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 257 mg/kg/30D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 160,123,1994
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 720 mg/kg/60D-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition
Kidney, Ureter, Bladder - inflammation, necrosis, or scarring of bladder
- REFERENCE :
- MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd.,
71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
Volume(issue)/page/year: 160,123,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 181 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,715,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 225 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,715,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 215 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 15,688,1984
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 690 mg/kg
- TOXIC EFFECTS :
- Behavioral - antipsychotic
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,715,1975
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 355 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- USXXAM United States Patent Document. (U.S. Patent Office, Box 9,
Washington, DC 20231) Volume(issue)/page/year: #4159986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 675 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho
Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
Volume(issue)/page/year: 15,688,1984
** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2190 mg/kg/1Y-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes
Related to Chronic Data - death
Related to Chronic Data - changes in ovarian weight
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,1743,1980
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1800 mg/kg
- SEX/DURATION :
- male 10 week(s) pre-mating
female 2 week(s) pre-mating - 6 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
6,195,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 7200 mg/kg
- SEX/DURATION :
- male 10 week(s) pre-mating
female 2 week(s) pre-mating - 6 day(s) after
conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
6,195,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 200 mg/kg
- SEX/DURATION :
- female 6-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental
Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa,
Takatsu-ku, Kawasaki 211, Japan) V.1- 1975- Volume(issue)/page/year:
6,205,1980
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 975 mg/kg
- SEX/DURATION :
- female 6-18 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
number of implants per female; total number of implants per corpora lutea)
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu
Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-
Volume(issue)/page/year: 8,1773,1980
噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸 上游产品
噻洛芬酸; 2-[5-(苯甲酰基)-2-噻吩基]丙酸 下游产品
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湖北江民泰华化工有限公司
噻洛芬酸
- 联系人:张经理
- 电 话:13396038321
- 手 机:13396038321
- Cas号:33005-95-7
- 包装:25kg,200kg
- 纯度:99%
- 价格:洽谈
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噻洛芬酸
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- 手 机:16621771607
- Cas号:33005-95-7
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- 纯度:
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噻洛芬酸
- 联系人:时燕
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- 手 机:13657207535
- Cas号:33005-95-7
- 包装:25mg,25mg,25mg,25mg,25mg
- 纯度:>98.0%(GC)(T)
- 价格:2,380.0元 - 2,380.0元
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噻洛芬酸
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- 手 机:13770649303
- Cas号:33005-95-7
- 包装:洽谈
- 纯度:
- 价格:洽谈