依米丁
- 中文名称：
- 依米丁
- 中文别名：
- 依米丁;
吐根碱
- 英文名称：
- 2H-Benzo[a]quinolizine,3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-1-isoquinolinyl]methyl]-,(2S,3R,11bS)-
- 英文别名：
- emetine;
EMETINE;
Emetine hydrochloride;
(2S,3R,11bS)-2-[[(1R)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl]-3-ethyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizine;
Emetine [BAN];
Emetin;
Cephaline-O-methyl ether;
Emetan,6',7',10,11-tetramethoxy;
10,11,6',7'-tetramethoxy-emetane;
Methyl cephaeline;
Cephaeline methyl ether
- CAS No.：
- 483-18-1
- 分 子 式：
-
C29H40N2O4
- 分 子 量：
- 0
- 精确分子量：
- 516.27500
- PSA：
- 52.19000
- EINECS：
- 207-592-1
- InChI：
- The Key: AUVVAXYIELKVAI-CKBKHPSWSA-N3
- 分子结构式：
-
- SDS：
- 查看
依米丁 物化性质
- 密度：
- 1.17g/cm3
- 熔点：
- 89-96ºC
- 沸点：
- 600.3ºC at 760mmHg
- 闪点：
- 316.9ºC
依米丁 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- DK1750000
- CHEMICAL NAME :
- 2H-Benzo(a)quinolizine,
3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2-((1,
2,3,4-
tetrahydro-6,7-dimethoxy-1-isoquinolyl)methyl)-
- CAS REGISTRY NUMBER :
- 483-18-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 18
- MOLECULAR FORMULA :
- C29-H40-N2-O4
- MOLECULAR WEIGHT :
- 480.71
- WISWESSER LINE NOTATION :
- T B666 GNTT&J E2 LO1 MO1 D1- BT66 CMT&J HO1 IO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Rinsed with water
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 10 mg/kg/10D
- TOXIC EFFECTS :
- Behavioral - muscle weakness
Cardiac - arrhythmias (including changes in conduction)
Gastrointestinal - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2941 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 12 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 8 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 7 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 25 mg/kg
- REFERENCE :
- JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
60,1049,1978
*** REVIEWS ***
TOXICOLOGY REVIEW
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate
Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year:
2,159,1973
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X4638
No. of Facilities: 7 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 103 (estimated)
No. of Female Employees: 52 (estimated)
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依米丁，吐根碱
- 联系人：马蕊
- 电 话：18162791556
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- Cas号：483-18-1
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- 纯度：98%
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- 联系人：蔡钊
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- Cas号：483-18-1
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- 联系人：
- 电 话：+852-21919580
- 手 机：
- Cas号：483-18-1
- 包装：洽谈
- 纯度：
- 价格：洽谈
