制备方法

可用于医院手术、注射等皮肤消毒和器械消毒,口腔、妇科、外科、皮肤科等防感染，家庭食具、器具等杀菌消毒，食品工业、养殖业用杀菌消毒及动物疾病防治等。聚维酮碘主要用于消毒防腐剂，用于化脓性皮炎、皮肤真菌感染、小面积轻度烧烫伤，也用于小面积皮肤、黏膜创口的消毒。其作用机制是本品接触创面或患处后，能解聚释放出所含碘发挥杀菌作用。特点是对组织刺激性小，适用于皮肤、黏膜感染。

用途简介

用途

具有碘的杀菌作用，在药剂中作杀菌消毒剂、抑菌剂，用于滴眼剂、滴鼻剂、乳膏剂等防腐，还可制成消毒液

海关代码：

3808940010

安全说明：

S24/25

安全标志：

S22:不要吸入粉尘。
S24/25:防止皮肤和眼睛接触。

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TR1579600

CHEMICAL NAME :

Poly(1-(2-oxo-1-pyrrolidinyl)ethylene)iodine complex

CAS REGISTRY NUMBER :

25655-41-8

LAST UPDATED :

199701

DATA ITEMS CITED :

22

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Administration onto the skin

SPECIES OBSERVED :

Human

DOSE/DURATION :

3400 mg/kg/24H

TOXIC EFFECTS :

Blood - hemorrhage Skin and Appendages - dermatitis, other (after systemic exposure)

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

>8 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3450 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

640 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

8100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4100 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

480 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

1450 mg/kg

SEX/DURATION :

female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - biochemical and metabolic Reproductive - Effects on Newborn - physical

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

11600 mg/kg

SEX/DURATION :

female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - live birth index (measured after birth) Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

DOSE :

11600 mg/kg

SEX/DURATION :

female 15-22 day(s) after conception lactating female 3 week(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - other postnatal measures or effects

MUTATION DATA

TYPE OF TEST :

Mutation in mammalian somatic cells

TEST SYSTEM :

Rodent - mouse Lymphocyte

DOSE/DURATION :

5000 ppm

REFERENCE :

APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) Volume(issue)/page/year: 19,A106,1980 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0524 No. of Facilities: 1794 (estimated) No. of Industries: 14 No. of Occupations: 15 No. of Employees: 65694 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7540 No. of Facilities: 7099 (estimated) No. of Industries: 35 No. of Occupations: 49 No. of Employees: 1075065 (estimated) No. of Female Employees: 939668 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9186 No. of Facilities: 798 (estimated) No. of Industries: 3 No. of Occupations: 16 No. of Employees: 94521 (estimated) No. of Female Employees: 86562 (estimated)

生态数据：

 

该物质对环境可能有危害，对水体应给予特别注意。

分子结构数据

1、摩尔折射率：无可用

2、   摩尔体积（cm³/mol）：无可用       

3、   等张比容（90.2K）：无可用

4、   表面张力（dyne/cm）：无可用

5、   极化率：无可用

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:0

3.氢键受体数量:1

4.可旋转化学键数量:1

5.互变异构体数量:2

6.拓扑分子极性表面积20.3

7.重原子数量:10

8.表面电荷:0

9.复杂度:120

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:2