Section 1. Chemical Product and Company Identification
Lidocaine Hydrochloride monohydrate
Common Name/
Trade Name
Lidocaine Hydrochloride monohydrate
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops. Cold water may be used.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
Products of Combustion These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), halogenated compounds.
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on As with most organic solids, fire is possible at elevated temperatures
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presence of an ignition source is a potential
Hazards dust explosion hazard.
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading
water on the contaminated surface and allow to evacuate through the sanitary system.
Section 7. Handling and Storage
Keep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
Precautions
ingest. Do not breathe dust. Wear suitable protective clothing. If ingested, seek medical advice immediately
and show the container or the label. Keep away from incompatibles such as oxidizing agents.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.
Lidocaine Hydrochloride monohydrate
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spill used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (crystalline powder.) Odor Odorless.
Taste Not available.
Molecular Weight 288.81 g/mole
Color White.
pH (1% soln/water) Not available.
Not available.
Boiling Point
Melting Point 74°C (165.2°F)
Critical Temperature Not available.
Specific Gravity Not available.
Vapor Pressure Not applicable.
Vapor Density Not available.
Volatility Not available.
Not available.
Odor Threshold
Water/Oil Dist. Coeff. Not available.
Ionicity (in Water) Not available.
Dispersion Properties See solubility in water.
Solubility Easily soluble in cold water.
Insoluble in diethyl ether.
Soluble in benzene, ethanol, chloroform
Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability Temperature Not available.
Excess heat, incompatible materials
Conditions of Instability
Incompatibility with various Reactive with oxidizing agents.
substances
Corrosivity Non-corrosive in presence of glass.
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.
Lidocaine Hydrochloride monohydrate
Section 11. Toxicological Information
Routes of Entry Absorbed through skin. Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 292 mg/kg [Mouse].
Chronic Effects on Humans Causes damage to the following organs: the nervous system.
May cause damage to the following organs: cardiovascular system, central nervous system (CNS).
Other Toxic Effects on Hazardous in case of ingestion.
Humans Slightly hazardous in case of skin contact (irritant), of inhalation.
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on
May cause adverse reproductive effects and birth defects (teratogenic) based on animal test data
Chronic Effects on Humans
Special Remarks on other Aute Potential Health Effects:
Toxic Effects on Humans Skin: May cause skin irritation and numbness (anesthetic effect). When applied to the skin, it produces an
anesthetic effect by blocking the signals at the nerve endings of the skin. when compounded with an ointment
and applied topically, It may be absorbed by the skin cause systemic effects similar to that of ingestion.
Eyes: May cause eye irritation and numbness.
Inhalation: Dust may cause respiratory tract irritation and numbness.
Ingestion: Harmful of swallowed. May cause abdominal discomfort, nausea, vomiting. May affect
behavior/central nervous system (convulsions/seizures, drowsiness, lightheadedness, dizziness, confusion,
disorientation, muscle twitching or trembling, somnolence, unusual excitement, unusual tiredness or
weakness, nervousness, restlessness), cardiovascular system (hypotension, change in heart rate with
possibe cardiac arrest). May also cause shortness of breath or trouble breathing, ringing or buzzing in the
ears, feeling hot, cold or numb, increased sweating, blurred or double vision.
Chronic Potential Health Effects:
Skin: May cause allergic skin reaction with rash, hives, swelling, or abnormal sensation at the site of
application.
Ingestion/Inhalation: It is rare, but it may cause allergic reaction with cough, difficulty swallowing or tongue
swelling, dizziness or fainting, hives or swelling of the eyelids, face or lips; itching or skin rash, stuffy nose,
chest tightness, shortness of breath, trouble breathing or wheezing.
Medical Conditions Aggravated by Exposure: Hypersensitivity to material; respiratory depression; existing
cardiac conditions; broken or inflammed skin, burns, or open wounds at the place of application. More can be
absorbed into the body quickly, which increases the chance of side effects; Liver disease (severe). The risk
of side effects may be increased because of the slower removal of lidocaine from the body.
Section 12. Ecological Information
Ecotoxicity Not available.
BOD5 and COD Not available.
Possibly hazardous short term degradation products are not likely. However, long term degradation products
Products of Biodegradation
may arise.
Toxicity of the Products The products of degradation are more toxic.
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Section 13. Disposal Considerations
Waste must be disposed of in accordance with federal, state and local environmental
Waste Disposal
control regulations.
Lidocaine Hydrochloride monohydrate
Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found. It is not listed on the TSCA inventory because it is a hydrate.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has
California
found to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is not on the European Inventory of Existing Commercial Chemical Substances.
Canada: Not listed on Canadian Domestic Substance List (DSL) or Canadian Non- Domestic Substance List
(NDSL).
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Not listed on AICS.
WHMIS (Canada) Not available under WHMIS (Canada).
Other Classifications
DSCL (EEC) R22- Harmful if swallowed. S36- Wear suitable protective clothing.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Lidocaine Hydrochloride monohydrate
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
SECTION 16 - ADDITIONAL INFORMATION
N/A