Section 1. Chemical Product and Company Identification
Methadone Hydrochloride
Common Name/
Trade Name
Methadone Hydrochloride
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water
for at least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops. Cold water may be used.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek
immediate medical attention.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious Inhalation Evacuate the victim to a safe area as soon as possible. Loosen tight clothing such as a collar, tie, belt or
waistband. Seek medical attention.
Ingestion If swallowed, do not induce vomiting unless directed to do so by medical personnel. Never give anything by
mouth to an unconscious person. Loosen tight clothing such as a collar, tie, belt or waistband. Get medical
attention immediately.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Not available.
Flash Points
Flammable Limits Not available.
Products of Combustion These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...).
Fire Hazards in Presence of Slightly flammable to flammable in presence of heat.
Various Substances Non-flammable in presence of shocks.
Risks of explosion of the product in presence of mechanical impact: Not available.
Explosion Hazards in
Slightly explosive in presence of open flames and sparks.
Presence of Various
Substances
SMALL FIRE: Use DRY chemical powder.
Fire Fighting Media
LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
and Instructions
Special Remarks on Not available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container.
Large Spill Poisonous solid.
Stop leak if without risk. Do not get water inside container. Do not touch spilled material. Use water spray
to reduce vapors. Prevent entry into sewers, basements or confined areas; dike if needed. Eliminate all
Section 7. Handling and Storage
Keep locked up.. Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire
Precautions
risk, evaporate the residue under a fume hood. Ground all equipment containing material. Do not ingest.
Do not breathe dust. Avoid contact with skin. Wear suitable protective clothing. In case of insufficient
ventilation, wear suitable respiratory equipment. If ingested, seek medical advice immediately and show the
container or the label. Keep away from incompatibles such as oxidizing agents.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.
Methadone Hydrochloride
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels
below recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep
exposure to airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be
a Large Spill used to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a
specialist BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (crystalline powder.) Odor Odorless.
Taste Not available.
Molecular Weight 345.91 g/mole
White.
Color
Not available.
pH (1% soln/water)
Boiling Point Not available.
235°C (455°F)
Melting Point
Critical Temperature Not available.
Not available.
Specific Gravity
Vapor Pressure Not applicable.
Vapor Density Not available.
Not available.
Volatility
Odor Threshold Not available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water) Not available.
Dispersion Properties See solubility in water.
Solubility Soluble in cold water.
Section 10. Stability and Reactivity Data
Stability The product is stable.
Not available.
Instability Temperature
Conditions of Instability Excess heat, dust generation, light, air, incompatible materials
Incompatibility with various Reactive with oxidizing agents.
substances
Corrosivity Not available.
Special Remarks on Air and light sensitive.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.
Methadone Hydrochloride
Section 11. Toxicological Information
Routes of Entry Absorbed through skin. Dermal contact. Eye contact. Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 30 mg/kg [Rat].
Chronic Effects on Humans Not available.
Other Toxic Effects on Very hazardous in case of ingestion.
Humans Hazardous in case of skin contact (permeator), of inhalation.
Slightly hazardous in case of skin contact (irritant).
Special Remarks on Lowest Published Lethal Dose:
Toxicity to Animals LDL [Child] - Route: Oral; Dose: 5 mg/kg
Special Remarks on May cause adverse reproductive effects and birth defects (teratogenic).
Chronic Effects on Humans Narcotic. May be habit forming. Overexposure could lead to physical dependence.
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: Not expected to be hazardous, but absorption and narcotic symptoms may follow with abraded or
inflammed skin.
Eyes: Causes mild irritation. The eye may also suffer narcotic effects such as pupil contraction or serve as
an absorption route.
Inhalation: Narcotic. Can irritate respiratory tract, but may also have a numbing action. Inhalation of large
amounts may cause lung edema, breathing difficulty, and central nervous system effects such as dizziness.
Ingestion: Danger! Highly Toxic! May be fatal if swallowed. May cause gastrointestinal tract irritation.
Affects brain, eyes, cardiovascular system, respiration, behavior/central nervous system. Symptoms may
include nausea, vomiting, constipation, sweating, respiratory depression, acute pulmonary edema, dyspnea,
apnea, cyanosis, sedation, lightheadedness, dizziness, euphoria, dysphoria, headache, weakness,
somnolence, stupor, coma, insomnia, agitation, disorientation, convulsions, analgesia, excitement, ataxia,
skeletal muscle flaccidity, cold and clammy skin, shock, circulatory depression, cardiac arrest, circulatory
collapse, bradycardia, hypotension, palpitations, faintness, syncope, flushing of the face, visual
disturbances, maximally restricted pupils, death.
Chronic Potential Health Effects:
Ingestion: Repeated or prolonged ingestion may cause Fibrosis (Pneumoconiosis), weight loss, skin
rashes, coughs, stuffy nose, asthma and other allergic complaints, and habituation (dependency).
Section 12. Ecological Information
Ecotoxicity Not available.
BOD5 and COD Not available.
Possibly hazardous short term degradation products are not likely. However, long term degradation
Products of Biodegradation
products may arise.
The products of degradation are less toxic than the product itself.
Toxicity of the Products
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14. Transport Information
DOT Classification CLASS 6.1: Poisonous material.
UNNA: 2811 : Toxic solid, organic, n.o.s. (Methadone Hydrochloride) PG: II
Identification
Special Provisions for Not available.
Transport
Methadone Hydrochloride
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California prop. 65: This product contains the following ingredients for which the State of California has
California
found to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations OSHA: Hazardous by definition of Hazard Communication Standard (29 CFR 1910.1200).
EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
No. 214-140-7).
Canada: Not listed on Canadian Domestic Substance List (DSL) or on Canadian Non-Domestic Substances
List
China: Not listed on National Inventory.
Japan: Not listed on National Inventory (ENCS).
Korea: Not listed on National Inventory (KECI).
Philippines: Not listed on National Inventory (PICCS).
Australia: Listed on AICS.
WHMIS (Canada) CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
Other Classifications
DSCL (EEC) R25- Toxic if swallowed. S45- In case of accident or if you feel unwell,
seek medical advice immediately (show the
label where possible).
Health Hazard
HMIS (U.S.A.) 3 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
3 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Methadone Hydrochloride
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
SECTION 16 - ADDITIONAL INFORMATION
N/A