五氯酚钠,131-52-2，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

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五氯酚钠

中文名称：: 五氯酚钠

中文别名：: 五氯酚钠;
五氯苯酚钠

英文名称：: Sodium pentachlorophenolate

英文别名：: sodium pentachlorophenoxide;
pentachlorophenate de sodium;
2,3,4,5,6-pentachlorophenol sodium salt;
pkhfn;
pentachlorophenol sodium salt;
mystoxd;
sapco25;
sodiumpcp;
pentachlorophenate sodium salt;
pentachlorophenol sodium alt;
gr48-32s;
dowicideg;
sodium pentachlorophenol*xH2O;
potassium pentachlorophenoxide;
gr48-11ps;
Sodium pentachlorophenolate;
sodium pentachlorophenolate;
sodium salt of pentachlorophenol;
sodium pentachlorophenate;
PCP-Na;
napclor-g

CAS No.：: 131-52-2

分子式：: C6Cl5NaO

分子量：: 288.32

精确分子量：: 285.82900

PSA：: 23.06000

MDL：: MFCD00002163

EINECS：: 205-025-2

BRN：: 3639137

InChI：: InChI=1/C6HCl5O.Na/c7-1-2(8)4(10)6(12)5(11)3(1)9;/h12H;/q;+13

风险术语：: 24/25-26-36/37/38-40-50/53

SDS：: 查看

五氯酚钠制备方法及用途

制备方法

1.由六氯苯水解制得。 2.在三氯苯中通氯气进行氯化,得六氯苯,再和一定浓度的烧碱溶液加热升温,在一定的温度和压力下进行水解,反应产物经冷却、结晶、过滤和干燥即可。 3.利用六六六无效体为原料,经高压水解制得五氯酚钠。先配制浓度为160g/L的氢氧化钠溶液,按六氯苯与氢氧化钠摩尔比为1:(2.5～2.6),将六氯苯加入碱液中,搅拌均匀后送入水解釜。搅拌升温至压力达到2MPa时,停止加热,利用反应热使压力升至2.55MPa,相应的温度为230℃,保持近20min,水解即完成。卸压出料,冷却结晶,即得产品。

合成制备方法

1.由六氯苯水解制得。

2.在三氯苯中通氯气进行氯化，得六氯苯，再和一定浓度的烧碱溶液加热升温，在一定的温度和压力下进行水解，反应产物经冷却、结晶、过滤和干燥即可。

3.利用六六六无效体为原料，经高压水解制得五氯酚钠。先配制浓度为160g/L的氢氧化钠溶液，按六氯苯与氢氧化钠摩尔比为1:(2.5～2.6),将六氯苯加入碱液中，搅拌均匀后送入水解釜。搅拌升温至压力达到2MPa时，停止加热，利用反应热使压力升至2.55MPa，相应的温度为230℃，保持近20min，水解即完成。卸压出料，冷却结晶，即得产品。

用途简介

1.本品用作塑料和橡胶(天然乳胶)防菌剂,杀菌、防霉效果良好,对提高胶乳的机械稳定性和化学稳定性也有一定效果,与氨并用效果更好。通常用其20%的水溶液,一般用量为0.3%,并用氨量为0.1%。本品低毒,可用于食品包装材料黏合剂,是一种有效防霉剂。本品还可用作非选择性接触型除草剂,主要防除以种子繁殖的杂草。本品亦用作木材、淀粉、糊精、酪朊、明胶等物质的防腐剂。 2.杀菌剂。五氯酚钠使用浓度一般为50mg/L,不宜与阳离子药剂(如季铵盐等)共用,但其与某些阴离子表面活性剂复合使用,能够显著降低其用量,并提高杀菌效果。 3.用作水性胶黏剂的防腐剂。木材上涂0.8%～1.0%本品溶液,可防止木材的霉变及腐败,用0.1%～2.0%溶液处理纺织品可达到抗菌防霉要求。也用作皮革、纸浆、胶黏剂及涂料等的防腐剂,用量一般为0.1%～0.4%。还用作触杀型土壤处理除草剂及用于消灭钉螺、蚂蟥等软体动物。对真菌有杀灭功效,并能防止藻类及黏菌生长,用于循环冷却水杀菌灭藻处理时,使用浓度为100～500mg/L。

用途

1.本品用作塑料和橡胶(天然乳胶)防菌剂，杀菌、防霉效果良好，对提高胶乳的机械稳定性和化学稳定性也有一定效果，与氨并用效果更好。通常用其20%的水溶液，一般用量为0.3%，并用氨量为0.1%。本品低毒，可用于食品包装材料黏合剂，是一种有效防霉剂。本品还可用作非选择性接触型除草剂，主要防除以种子繁殖的杂草。本品亦用作木材、淀粉、糊精、酪朊、明胶等物质的防腐剂。
2.杀菌剂。五氯酚钠使用浓度一般为50mg/L，不宜与阳离子药剂（如季铵盐等）共用，但其与某些阴离子表面活性剂复合使用，能够显著降低其用量，并提高杀菌效果。
3.用作水性胶黏剂的防腐剂。木材上涂0.8%～1.0%本品溶液，可防止木材的霉变及腐败，用0.1%～2.0%溶液处理纺织品可达到抗菌防霉要求。也用作皮革、纸浆、胶黏剂及涂料等的防腐剂，用量一般为0.1%～0.4%。还用作触杀型土壤处理除草剂及用于消灭钉螺、蚂蟥等软体动物。对真菌有杀灭功效，并能防止藻类及黏菌生长，用于循环冷却水杀菌灭藻处理时，使用浓度为100～500mg/L。

五氯酚钠物化性质

密度：
1.804g/cm3

熔点：
>300°C

沸点：
309.5ºC at 760mmHg

闪点：
133.7ºC

存储条件/存储方法：
库房通风低温干燥,与氧化剂、食品添加剂分开存放

稳定性相关：
1.水溶液呈弱碱性，加酸酸化至PH6.8-6.6时，全部析出为五氯酚。受日光照射易分解，干燥时性质稳定，有特殊气味。
2.空气中浓度超标时，必须佩戴防毒口罩。操作人员应穿防酸碱工作服，戴防化学品手套，必要时戴安全防护眼镜。尽可能减少与本品直接接触。

其它信息：

1.         性状：白色或淡黄色针状结晶
2.         熔点（℃）：190
3.         溶解性：易溶于水、乙醇、甲醇、丙酮，微溶于四氯化碳和二硫化碳。

五氯酚钠安全信息

包装等级：
II

风险类别：
6.1(a)

海关代码：
2908199023

危险类别码：
R24/25;R26;R36/37/38;R40;R50/53

安全说明：
S1/2-S22-S36/37-S45-S61-S60-S52-S28

RTECS号：
SM6490000

安全标志：
S22:不要吸入粉尘。
S28:接触皮肤之后，立即使用大量皂液洗涤。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
S52:不建议在大面积内部空间使用。
S60:本物质残余物和容器必须作为危险废物处理。
S61:避免排放到环境中。参考专门的说明/安全数据表。
:

危险标志：
T+:Verytoxic;N:Dangerous for the environment;

五氯酚钠毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SM6490000

CHEMICAL NAME :
Phenol, pentachloro-, sodium salt

CAS REGISTRY NUMBER :
131-52-2

LAST UPDATED :
199801

DATA ITEMS CITED :
33

MOLECULAR FORMULA :
C6-Cl5-O.Na

MOLECULAR WEIGHT :
288.30

WISWESSER LINE NOTATION :
QR BG CG DG EG FG &-NA-
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
126 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
11700 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
66 mg/kg

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Endocrine - hyperglycemia Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intratracheal

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
146 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
197 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
240 mg/m3/2H

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
124 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
63700 ug/kg

TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation Skin and Appendages - hair

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
56 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intratracheal

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
164 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
135 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
328 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
250 mg/kg

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Endocrine - hyperglycemia Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intraperitoneal

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
50 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
100 mg/kg

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Endocrine - hyperglycemia Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
22 mg/kg

TOXIC EFFECTS :
Vascular - BP elevation not characterized in autonomic section Endocrine - hyperglycemia Nutritional and Gross Metabolic - body temperature increase

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
250 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
341 mg/m3/2H

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Administration onto the skin

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
266 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intratracheal

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
120 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
500 mg/m3/13W-I

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
500 mg/m3/13W-I

TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
500 mg/m3/13W-I

TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :
Inhalation

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
500 mg/m3/13W-I

TOXIC EFFECTS :
Liver - fatty liver degeneration Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :
TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :
Oral

DOSE :
360 mg/kg

SEX/DURATION :
female 8-19 day(s) after conception

TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA

TYPE OF TEST :
DNA repair

TEST SYSTEM :
Bacteria - Bacillus subtilis

DOSE/DURATION :
5 ug/disc

REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,19,1976 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 69270 No. of Facilities: 3778 (estimated) No. of Industries: 49 No. of Occupations: 46 No. of Employees: 23402 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 69270 No. of Facilities: 1439 (estimated) No. of Industries: 21 No. of Occupations: 30 No. of Employees: 16153 (estimated) No. of Female Employees: 1615 (estimated)

毒理学数据：

急性毒性：口服-大鼠 LD50: 126 毫克/公斤;口服-小鼠 LC50: 197 毫克/公斤。
本品对眼和呼吸道有刺激性。人长期接触，偶见周围神经炎。对黏膜有刺激作用，溶液浓度超过1%时，对皮肤有刺激作用。

生态数据：

有强烈的刺激性，对人和牲畜毒性中等，对鱼类有很强的毒性，鱼虾的致死浓度为LC50为0.3-0.6mg/L。

五氯酚钠 MSDS

第一部分：化学品名称

五氯酚钠分子结构与计算化学数据

计算化学数据

1、   疏水参数计算参考值（XlogP）：
2、   氢键供体数量：0
3、   氢键受体数量：1
4、   可旋转化学键数量：0
5、   互变异构体数量：
6、   拓扑分子极性表面积（TPSA）：23.1
7、   重原子数量：13
8、   表面电荷：0
9、   复杂度：155
10、同位素原子数量：0
11、确定原子立构中心数量：0
12、不确定原子立构中心数量：0
13、确定化学键立构中心数量：0
14、不确定化学键立构中心数量：0
15、共价键单元数量：2

五氯酚钠上游产品

五氯苯酚标准溶液

五氯酚钠下游产品

 1,2,3,4,6,7,8,9-八氯联苯-P-二噁英四氯邻苯醌四氯邻苯二酚四氯苯醌

五氯酚钠表征图谱

五氯苯酚钠盐红外图谱(IR1)

五氯苯酚钠盐红外图谱(IR2)

推荐供应商

五氯酚钠

五氯酚钠 制备方法及用途

制备方法

合成制备方法

用途简介

用途

五氯酚钠 物化性质

五氯酚钠 安全信息

五氯酚钠 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

五氯酚钠 MSDS

五氯酚钠 分子结构与计算化学数据

计算化学数据

五氯酚钠 上游产品

五氯酚钠 下游产品

五氯酚钠 表征图谱

推荐供应商

五氯酚钠制备方法及用途

五氯酚钠物化性质

五氯酚钠安全信息

五氯酚钠毒理性

五氯酚钠分子结构与计算化学数据

五氯酚钠上游产品

五氯酚钠下游产品

五氯酚钠表征图谱