偏二甲肼,57-14-7，生产厂家，价格-洛克化工网移动版

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制备方法及用途

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偏二甲肼

中文名称：: 偏二甲肼

中文别名：: 偏二甲肼;
偏二甲基肼;
N,N-二甲基肼;
1，1-二甲基肼

英文名称：: 1,1-Dimethylhydrazine

英文别名：: 1,1-dimethylhydrazine;
gem-Dimethylhydrazine;
UDMH;
as-Dimethylhydrazine;
Hydrazine,1,1-dimethyl;
1,1-Dimethylhydrazin;
N,N-dimethylhydrazine;
Dimazine;
Dimethylhydrazine;
1,1-dimethyl-hydrazine;
N1,N1-dimethylhydrazine;
1,1-Dimethylhydrazine

CAS No.：: 57-14-7

分子式：: C2H8N2

分子量：: 60.1

精确分子量：: 60.06870

PSA：: 29.26000

MDL：: MFCD00007628

EINECS：: 200-316-0

BRN：: 605261

InChI：: InChI=1/C2H8N2/c1-4(2)3/h3H2,1-2H33

风险术语：: 45-11-23/25-34-51/53

SDS：: 查看

偏二甲肼制备方法及用途

制备方法

1.本品可以氨水;氯化胺和二甲胺为原料经反应合成制得。先将氨水和次氯酸钠分别送入一步反应器进行反应生成氯代胺,然后将氯代胺送入二步反应器与二甲胺水溶液进行合成,生成偏二甲肼水溶液,再将此合成液送入一系列精馏塔进一步蒸馏精馏,脱除过量的氨;二甲胺和偏腙,加碱提浓、脱气后,即得成品。 2.制N,N-二甲肼在装有机械搅拌器、滴液漏斗和温度计的5升圆底烧瓶中,加入200克(2.7摩尔)亚硝基二甲胺、3升水和650克(10克原.子)100%的锌粉。将反应混合物置水浴中加热以保持温度在25-30℃,在搅拌下滴加1升(14摩尔)85%乙酸,约2小时。然后在60℃加热1小时,冷却,滤去多余的锌粉,并用少量水洗涤合并水溶液,置于进行水汽蒸馏的12升烧瓶中,烧版上装滴液漏斗,从漏斗中加入1000克氢氧化钠浓溶液使水溶液呈明显的碱性,进行水汽蒸馏直至馏出物对Fehling溶液只有微弱的还原作用时为止,约蒸出5一6升馏出物即足以将二甲肼完全带出。馏出液用650毫升浓盐酸处理后,在减压和蒸汽浴上浓缩,直残余物变浆状为止。将浆状物滴到大过量的固体氢氧化钠上,再进行蒸馏直至温度升至100℃为止,可得到二甲肼的浓水溶液。若在二甲肼浓水溶液中加入氢氧化钾,放置干燥,重行蒸馏,馏出液收集于盛有氢氧化钡的接受器中,放置数日后再进行蒸馏,收集62~65℃/765mm馏份即为无水二甲肼。若将浆状物用无水乙醇处理后可得到白色晶体的二甲肼盐酸盐。

合成制备方法

1.本品可以氨水；氯化胺和二甲胺为原料经反应合成制得。先将氨水和次氯酸钠分别送入一步反应器进行反应生成氯代胺，然后将氯代胺送入二步反应器与二甲胺水溶液进行合成，生成偏二甲肼水溶液，再将此合成液送入一系列精馏塔进一步蒸馏精馏，脱除过量的氨；二甲胺和偏腙，加碱提浓、脱气后，即得成品。

2.制N，N-二甲肼
在装有机械搅拌器、滴液漏斗和温度计的5升圆底烧瓶中，加入200克(2.7摩尔)亚硝基二甲胺、3升水和650克(10克原.子)100%的锌粉。将反应混合物置水浴中加热以保持温度在25-30℃，在搅拌下滴加1升(14摩尔)85%乙酸，约2小时。然后在60℃加热1小时，冷却，滤去多余的锌粉，并用少量水洗涤合并水溶液，置于进行水汽蒸馏的12升烧瓶中，烧版上装滴液漏斗，从漏斗中加入1000克氢氧化钠浓溶液使水溶液呈明显的碱性，进行水汽蒸馏直至馏出物对Fehling溶液只有微弱的还原作用时为止，约蒸出5一6升馏出物即足以将二甲肼完全带出。
馏出液用650毫升浓盐酸处理后，在减压和蒸汽浴上浓缩，直残余物变浆状为止。将浆状物滴到大过量的固体氢氧化钠上，再进行蒸馏直至温度升至100℃为止，可得到二甲肼的浓水溶液。若在二甲肼浓水溶液中加入氢氧化钾，放置干燥，重行蒸馏，馏出液收集于盛有氢氧化钡的接受器中，放置数日后再进行蒸馏，收集62~65℃/765mm馏份即为无水二甲肼。若将浆状物用无水乙醇处理后可得到白色晶体的二甲肼盐酸盐。

用途简介

1.该品用于生产植物生长调节剂,其苯酚盐可减少润滑盐的沉积现象。还可用于吸收酸性气体,也可用作分析试剂,高能燃料,溶剂。 2.羰基的保护试剂。用于众多的增环反应,N,N一二甲腙的烷化α,β一不饱和酮的单烷化以及转变醛为腈。 3.用于化学合成,用作有机过氧化物的稳定剂、酸性气体吸收剂,还用于照相及农业。

用途

1.该品用于生产植物生长调节剂，其苯酚盐可减少润滑盐的沉积现象。还可用于吸收酸性气体，也可用作分析试剂，高能燃料，溶剂。

2.羰基的保护试剂。用于众多的增环反应，N，N一二甲腙的烷化α，β一不饱和酮的单烷化以及转变醛为腈。

3.用于化学合成，用作有机过氧化物的稳定剂、酸性气体吸收剂，还用于照相及农业。^[28]

偏二甲肼物化性质

外观与性状：: 绿色或棕色粉末
密度：: 0.79 g/mL at 20 °C(lit.)
熔点：: -57.2 °C
沸点：: 60-62 °C(lit.)
闪点：: 34 °F
水溶解性：: miscible
折射率：: n20/D 1.4075(lit.)
蒸汽密度：: 1.94 (vs air)
存储条件/存储方法：: 库房通风低温干燥,与氧化剂、酸类分开存放
稳定性相关：: 1.化学性质：有强还原性，与任何氧化剂接触均导致燃烧、爆炸。有强吸湿性。与酸作用生成盐；与亚硝酸作用生成二甲胺；与醛、酮反应生成腙。
2.剧毒，可致癌。蒸气吸入后出现鼻腔及咽喉部的刺激症状，呼吸困难，恶心、剧烈呕吐及神经系统症状，神经衰弱，步态不稳，抽搐、昏迷等。眼部表现为轻度结膜炎。白鼠经口LD50为265mg/kg。工作场所空气中有毒物质时间加权平均容许浓度为0.5mg/m3；短时间接触容许浓度为1.5mg/m3。中毒后无特效解毒剂，只能对症治疗。美国职业安全与健康管理局规定空气中最大容许曝露浓度为1mg/m3。
3.稳定性^[23] 稳定
4.禁配物^[24] 氧化剂、铜及其合金、铝、铁、铁盐
5.避免接触的条件^[25] 受热
6.聚合危害^[26] 不聚合
其它信息：: 1.性状：无色带有氨气味的液体，具有吸湿性。^[1]
2.熔点（℃）：-58^[2]
3.沸点（℃）：63.9^[3]
4.相对密度（水=1）：0.78（25℃）^[4]
5.相对蒸气密度（空气=1）：2.1^[5]
6.饱和蒸气压（kPa）：16.4（20℃）^[6]
7.燃烧热（kJ/mol）：-1979^[7]
8.临界温度（℃）：250^[8]
9.临界压力（MPa）：5.42^[9]
10.辛醇/水分配系数：-1.19^[10]
11.闪点（℃）：-15（CC）^[11]
12.引燃温度（℃）：249^[12]
13.爆炸上限（%）：95^[13]
14.爆炸下限（%）：2.0^[14]
15.溶解性：与水混溶，混溶于二甲基甲酰胺、乙醇、乙醚、烃。^[15]
16.折射率（25ºC）：1.4508
17.燃点（ºC）：249
18.蒸发热（KJ/mol）：35.02
19.熔化热（KJ/mol）：10.08
20.生成热（KJ/mol）：49.37

偏二甲肼毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MV2450000

CHEMICAL NAME :: Hydrazine, 1,1-dimethyl-

CAS REGISTRY NUMBER :: 57-14-7

BEILSTEIN REFERENCE NO. :: 0605261

LAST UPDATED :: 199712

DATA ITEMS CITED :: 94

MOLECULAR FORMULA :: C2-H8-N2

MOLECULAR WEIGHT :: 60.12

WISWESSER LINE NOTATION :: ZN1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 122 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 252 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 102 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 119 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intracerebral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 172 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 113 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - miosis (pupillary constriction) Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 3580 ppm/15M

TOXIC EFFECTS :: Gastrointestinal - hypermotility, diarrhea Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 301 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Primate - monkey

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - cyanosis

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1060 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1329 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 392 ppm/4H

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 34 gm/m3/13M/40D

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - chronic pulmonary edema

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 630 mg/kg/3W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 150 mg/kg/7W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 21 mg/kg

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5880 mg/kg/42W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 144 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 420 mg/kg/21W-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 228 gm/kg/48W-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Vascular - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: 2686 mg/kg/72W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Peripheral Nerve and Sensation - peripheral nerve tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 288 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/20W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg/14W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Gastrointestinal - colon tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg/25W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 600 mg/kg

SEX/DURATION :: female 6-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: Morphological transformation

TYPE OF TEST :: Unscheduled DNA synthesis

TYPE OF TEST :: Micronucleus test

TYPE OF TEST :: DNA damage

TYPE OF TEST :: DNA inhibition

TYPE OF TEST :: Sister chromatid exchange

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 130,121,1984 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.025 mg/m3 (0.01 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,137,1974 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 4,137,1974 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ATXKA8 Archiv fuer Toxikologie. (Berlin, Fed. Rep. Ger.) V.15-31, 1954-74. For publisher information, see ARTODN. Volume(issue)/page/year: 28,135,1971 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 0.5 ppm (1 mg/m3) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,91,1971 OSHA PEL (Gen Indu):8H TWA 0.5 ppm (1 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.5 ppm (1 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.5 ppm (1 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.5 ppm (1 mg/m3) (skin) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.5 ppm (1 mg/m3);Skin;Carcinogen JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.25 mg/m3);Skin;Carcinogen JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.25 mg/m3);Skin;Carcinogen JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.2 mg/m3);Carcinogen JAN 1993 OEL-GERMANY;Skin;Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 0.5 ppm (1 mg/m3);Skin JAN 1993 OEL-THE PHILIPPINES:TWA 0.5 ppm (1 mg/m3);Skin JAN 1993 OEL-SWEDEN:TWA 0.1 ppm (0.2 mg/m3);STEL 0.5 ppm (0.5 mg/m3);Skin;Carcinogen JAN 1993 OEL-SWITZERLAND:TWA 0.5 ppm (1.2 mg/m3);Skin;Carcinogen JAN 1993 OEL-TURKEY:TWA 0.5 ppm (1 mg/m3);Skin JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 1,1-DIMETHYLHYDRAZINE-air:CA CL 0.06 ppm/120M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84395 No. of Facilities: 14 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 25 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84395 No. of Facilities: 43 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 2917 (estimated)

毒理学数据：

1.急性毒性^[16]

LD50：122mg/kg（大鼠经口）；1060mg/kg（兔经皮）

LC50：252ppm（大鼠吸入，4h）

2.刺激性 暂无资料

3.亚急性与慢性毒性^[17] 狗吸入12.5mg/m³，每天6h，5次/周，26周，体重减轻、嗜睡、轻度贫血。

4.致突变性^[18] 微生物致突变：鼠伤寒沙门菌42μmol/皿。DNA修复：大肠杆菌600μg/皿。DNA损伤：人成纤维细胞300μmol/L。

5.致癌性^[19] IARC致癌性评论：G2B，人类可疑致癌物。

生态数据：

1.生态毒性^[20]

LC50：11.35mg/L（96h）（斑点叉尾鮰）；7.85mg/L（96h）（黑头呆鱼，30d）；38mg/L（24h）（水蚤）

2.生物降解性^[21]

好氧生物降解（h）：192~528

厌氧生物降解（h）：768~2112

3.非生物降解性^[22]

空气中光氧化半衰期（h）：0.8~7.7

偏二甲肼 MSDS

国标编号:	32184
ＣＡＳ:	57-14-7
中文名称:	1,1-二甲基肼
英文名称:	Dimethyl hydrazine(unsymmetrical)；1,1-Dimethyl hydrazine
别名:	二甲基肼(不对称)
分子式:	C₂H₈N₂；(CH₃)₂NNH₂
分子量:	60.1
熔点:	-58℃ 沸点：63.3℃
密度:	相对密度(水=1)0.78(2
蒸汽压:	-15℃
溶解性:	溶于水、乙醇和乙醚
稳定性:	稳定
外观与性状:	无色带有氨气味的液体，具有吸湿性
危险标记:	7(易燃液体)
用途:	用于化学合成，用作有机过氧化物的稳定剂、酸性气体吸收剂，还用于照相及农业

2.对环境的影响: 一、健康危害侵入途径：吸入、食入、经皮吸收。健康危害：吸入、摄入或经皮吸收后对身体有害。本品对皮肤、眼睛、粘膜和上呼吸道有剧烈刺激作用。吸入后，可引起喉、支气管的痉挛、炎症和水肿，化学性肺炎、肺水肿。接触后可引起烧灼感、咳嗽、喉炎、眩晕、头痛、恶心和呕吐。二、毒理学资料及环境行为毒性：属中等毒类。急性毒性：LD50120mg/kg(大鼠经口)；LC50大鼠吸入：252ppm，4小时；630mg/m3，4小时(大鼠吸入) 亚急性和慢性毒性：狗吸入12.5mg/m3，6小时/天，5次/周，26周，体重减轻、嗜睡、轻度贫血。致突变性：微生物致突变：鼠伤寒沙门氏菌阳性。致癌性：IARC致癌性评论：对人可能致癌。危险特性：其蒸气与空气形成爆炸性混合物，遇明火、高热极易燃烧爆炸。与氧化剂能发生强烈反应，引起燃烧或爆炸。燃烧(分解)产物：一氧化碳、二氧化碳、氧化氮。 3.现场应急监测方法: 　 4.实验室监测方法: 氨基亚铁氰化钠分光光度法(GB/T14376-93，水质) 气相色谱法；分光光度法《空气和废气监测分析方法》，国家环保局编 5.环境标准: 前苏联车间空气中有害物质的最高容许浓度 0.1mg/m3 嗅觉阈浓度 <6ppm 6.应急处理处置方法: 一、泄漏应急处理疏散泄漏污染区人员至安全区，禁止无关人员进入污染区。应急处理人员戴正压自给式呼吸器，穿化学防护服。不要直接接触泄漏物。在确保安全情况下堵漏。喷水雾会减少蒸发。用大量水冲洗，经稀释的洗液放入废水系统。二、防护措施呼吸系统防护：可能接触其蒸气时，应该佩戴防毒口罩。眼睛防护：戴化学安全防护眼镜。身体防护：穿胶布防毒服。手防护：必要时戴防化学品手套。其它：工作现场严禁吸烟。工作后，淋浴更衣。实行就业前和定期的体检。保持良好的卫生习惯。三、急救措施皮肤接触：脱去污染的衣着，用肥皂水及清水彻底冲洗。若有灼伤，就医治疗。眼睛接触：立即翻开上下眼睑，用流动清水冲洗15分钟。就医。吸入：迅速脱离现场至空气新鲜处。呼吸困难时给输氧。呼吸停止时，立即进行人工呼吸。就医。食入：误服者漱口，饮牛奶或蛋清，就医。灭火方法：大火可用水，小火可用二氧化碳、干粉、砂土。

偏二甲肼

偏二甲肼制备方法及用途

制备方法

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偏二甲肼物化性质

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偏二甲肼毒理性

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HEALTH HAZARD DATA

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偏二甲肼 MSDS

偏二甲肼分子结构与计算化学数据

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偏二甲肼

偏二甲肼 制备方法及用途

制备方法

合成制备方法

用途简介

用途

偏二甲肼 物化性质

偏二甲肼 安全信息

偏二甲肼 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

偏二甲肼 MSDS

偏二甲肼 分子结构与计算化学数据

分子结构数据

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偏二甲肼 表征图谱

推荐供应商

偏二甲肼制备方法及用途

偏二甲肼物化性质

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偏二甲肼分子结构与计算化学数据

偏二甲肼上游产品

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偏二甲肼表征图谱