危险类别码：

R36/37/38

安全说明：

S22-S26-S36/37

RTECS号：

TL4025000

安全标志：

S22:不要吸入粉尘。
S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:

危险标志：

Xn

CHEMICAL IDENTIFICATION

RTECS NUMBER :

TL4025000

CHEMICAL NAME :

Piperazine, dihydrochloride

CAS REGISTRY NUMBER :

142-64-3

LAST UPDATED :

199712

DATA ITEMS CITED :

18

MOLECULAR FORMULA :

C4-H10-N2.2Cl-H

MOLECULAR WEIGHT :

159.08

WISWESSER LINE NOTATION :

T6M DMTJ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

4900 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,416,1973

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1970 mg/kg

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :

JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,475,1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

2030 mg/kg

REFERENCE :

ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 4,649,1954 *** REVIEWS *** ACGIH TLV-TWA 5 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** OSHA PEL (Construc):skin CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 5 mg/m3 JAN 1993 OEL-BELGIUM:TWA 5 mg/m3 JAN 1993 OEL-DENMARK:TWA 5 mg/m3 JAN 1993 OEL-FRANCE:TWA 5 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 5 mg/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 5 mg/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PIPERAZINE-air:10H TWA 5.0 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80559 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1284 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80559 No. of Facilities: 163 (estimated) No. of Industries: 1 No. of Occupations: 12 No. of Employees: 5730 (estimated)

毒理学数据：

二、毒理学数据：

1、急性毒性：大鼠经口LD50：4900 mg/kg；

             小鼠腹腔LD50：1970 mg/kg.

             小鼠皮下LD50：2030 mg/kg.

生态数据：

三、生态学数据：

1、其它有害作用：该物质对环境可能有危害，对水体应给予特别注意。

分子结构数据

五、分子性质数据：

1、   摩尔折射率：25.14

2、   摩尔体积（m³/mol）：98.5

3、   等张比容（90.2K）：225.8

4、   表面张力（dyne/cm）：27.5

5、   极化率（10^-24cm³）：9.96

计算化学数据

1.疏水参数计算参考值（XlogP）:无

2.氢键供体数量:4

3.氢键受体数量:2

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积24.1

7.重原子数量:8

8.表面电荷:0

9.复杂度:26.5

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:3

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  哌嗪二盐酸盐红外图谱(IR1)
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  哌嗪二盐酸盐红外图谱(IR2)
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  哌嗪二盐酸盐质谱(MS)
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  哌嗪二盐酸盐核磁图(¹³CNMR)
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  哌嗪二盐酸盐Raman光谱