制备方法

链霉菌培养液经醇提、浓缩制得复合物粗晶,再在甲醇:水:四氯化碳:己烷中逆流分配分离而得纯品。

合成制备方法

链霉菌培养液经醇提、浓缩制得复合物粗晶，再在甲醇：水：四氯化碳：己烷中逆流分配分离而得纯品。

用途简介

细胞呼吸抑制剂。药物试验中用作杀真菌剂、杀虫剂、杀螨剂。

用途

细胞呼吸抑制剂。药物试验中用作杀真菌剂、杀虫剂、杀螨剂。

包装等级：

II

风险类别：

6.1(a)

危险类别码：

23/24/25

CHEMICAL IDENTIFICATION

RTECS NUMBER :

NY1503500

CHEMICAL NAME :

Isovaleric acid, 8-ester with 3-formamido-N-(7-hexyl-8-hydroxy-4,9-dimethyl-2,6-dio xo-1,5- dioxonan-3-yl)salicylamide

CAS REGISTRY NUMBER :

642-15-9

LAST UPDATED :

199309

DATA ITEMS CITED :

5

MOLECULAR FORMULA :

C28-H40-N2-O9

MOLECULAR WEIGHT :

548.70

WISWESSER LINE NOTATION :

T B666 COV KO&&TJ L1 L1 MOV1Y1&1 NOV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1469 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7600 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

25 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

900 ug/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,144,1967

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intramuscular

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

1 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 7(2),1,1975

毒理学数据：

1、急性毒性：小鼠经口LD50：1469mg/kg；小鼠经腹腔LD50：7600μg/kg；小鼠经皮下LD50：25mg/kg；小鼠经静脉LD50：900μg/kg；小鼠经肌肉注射LD50：1mg/kg；