曲马多
- 中文名称：
- 曲马多
- 中文别名：
- (+-)-反-1-(间-甲氧基苯基)-2-[(二甲氨基)-甲基]-环己醇;
(1R,2R)-2-(二甲氨基甲基)-1-(3-甲氧基苯基)环己-1-醇;
曲马多
- 英文名称：
- (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol
- 英文别名：
- (1R,2R)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol;
Ralivia flashtab;
Ralivia ER;
Tramadolum;
Ultram;
Tramal;
Tridural
- CAS No.：
- 27203-92-5
- 分 子 式：
-
C16H25NO2
- 分 子 量：
- 263.37500
- 精确分子量：
- 263.18900
- PSA：
- 32.70000
- InChI：
- The Key: TVYLLZQTGLZFBW-GOEBONIOSA-N3
- 风险术语：
- 22
- SDS：
- 查看
曲马多 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GV8925000
- CHEMICAL NAME :
- Cyclohexanol,
2-((dimethylamino)-1-(3-methoxyphenyl)-, cis-(+-)-
- CAS REGISTRY NUMBER :
- 27203-92-5
- LAST UPDATED :
- 199807
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C16-H25-N-O2
- MOLECULAR WEIGHT :
- 263.42
- WISWESSER LINE NOTATION :
- L6TJ AQ AR CO1& B1N1&1 -T
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 4032 ug/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - other changes
- REFERENCE :
- SMJOAV Southern Medical Journal. (Southern Medical Assoc., POB 2446,
Birmingham, AL 35205) V.1- 1908- Volume(issue)/page/year: 90,826,1997
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 228 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- EPXXDW European Patent Application. (U.S. Patent and Trademark Office,
Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #0047990
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 286 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971