制备方法

制法 Cl2＋3F2＝2ClF3装置与制ClF相同。可以不用液态氧冷却的阱。反应炉加热到230℃。氯气流缓慢一些。如果F2对于Cl2比例太小则主要形成ClF，且ClF3中含有较多的Cl2。氟化完毕后，把用干冰冷却的气阱中凝集的液态ClF3倾入一个用干冰冷却的钢瓶中并立刻关紧。当钢瓶温度升至室温时，连上压力计打开阀门，使气体放出直至0.122MPa为止。此时ClF，Cl2，F2均挥发逸出。收率随Cl2∶F2的值而定，一般可达60%～85％。

合成制备方法

制法 Cl₂＋3F₂＝2ClF₃

装置与制ClF相同。可以不用液态氧冷却的阱。反应炉加热到230℃。氯气流缓慢一些。如果F2对于Cl₂比例太小则主要形成ClF，且ClF₃中含有较多的Cl₂。

氟化完毕后，把用干冰冷却的气阱中凝集的液态ClF₃倾入一个用干冰冷却的钢瓶中并立刻关紧。当钢瓶温度升至室温时，连上压力计打开阀门，使气体放出直至0.122MPa为止。此时ClF，Cl₂，F₂均挥发逸出。收率随Cl₂∶F₂的值而定，一般可达60%～85％。

用途简介

用作氟化剂、燃烧剂、推进剂中的氧化剂、高温金属的切割油。

用途

用作氟化剂、燃烧剂、推进剂中的氧化剂、高温金属的切割油。

风险类别：

2.3

海关代码：

2812901910

危险类别码：

8-35

安全说明：

S17-S38

安全标志：

S17:远离可燃物质。
S38:在通风不良的场所，佩戴合适的呼吸装置。

危险标志：

O

CHEMICAL IDENTIFICATION

RTECS NUMBER :

FO2800000

CHEMICAL NAME :

Chlorine fluoride

CAS REGISTRY NUMBER :

7790-91-2

LAST UPDATED :

199712

DATA ITEMS CITED :

34

MOLECULAR FORMULA :

Cl-F3

MOLECULAR WEIGHT :

92.45

WISWESSER LINE NOTATION :

G F3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rat

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Mammal - dog

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955 ** ACUTE TOXICITY DATA **

TYPE OF TEST :

LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Human

DOSE/DURATION :

50 ppm

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,651,1966

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

299 ppm/1H

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 42,417,1977

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

178 ppm/1H

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-70-77,1970

TYPE OF TEST :

LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

230 ppm/1H

TOXIC EFFECTS :

Behavioral - muscle weakness Lungs, Thorax, or Respiration - chronic pulmonary edema Lungs, Thorax, or Respiration - cyanosis

REFERENCE :

AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433) Volume(issue)/page/year: TR-70-77,1970 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

5150 ppb/6H/6W-I

TOXIC EFFECTS :

Lungs, Thorax, or Respiration - chronic pulmonary edema Gastrointestinal - changes in structure or function of salivary glands Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1170 ppb/6H/26W-I

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - chronic pulmonary edema Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,340,1956

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

5150 ppb/6H/6W-I

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - corneal damage Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis) Related to Chronic Data - death

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 12,515,1955

TYPE OF TEST :

TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :

Inhalation

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1170 ppb/6H/26W-I

REFERENCE :

AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 13,340,1956 *** REVIEWS *** ACGIH TLV-CL 0.38 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 27,527,1974 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD:air-CL 0.1 ppm (0.4 mg/m3) DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. Volume(issue)/page/year: 3,11,1972 OSHA PEL (Gen Indu):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):CL 0.1 ppm (0.4 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-BELGIUM:STEL 0.1 ppm (0.38 mg/m3) JAN 1993 OEL-DENMARK:STEL 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-FINLAND:STEL 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-FRANCE:STEL 0.4 mg/m3 JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.4 mg/m3);STEL 0.2 ppm (0.8 mg/m3) JAN 1993 OEL-THAILAND:TWA 0.1 ppm (0.4 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.4 mg/m3);STEL 0.1 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLORINE TRIFLUORIDE-air:CL 0.1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 18050 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 357 (estimated)

毒理学数据：

急性毒性：LC50299ppm，1小时(大鼠吸入)；178ppm，1小时(小鼠吸入) 。

计算化学数据

1.疏水参数计算参考值（XlogP）:2.5

2.氢键供体数量:0

3.氢键受体数量:3

4.可旋转化学键数量:0

5.互变异构体数量:无

6.拓扑分子极性表面积0

7.重原子数量:4

8.表面电荷:0

9.复杂度:8

10.同位素原子数量:0

11.确定原子立构中心数量:0

12.不确定原子立构中心数量:0

13.确定化学键立构中心数量:0

14.不确定化学键立构中心数量:0

15.共价键单元数量:1