Section 1: Product Identification
Chemical Name: (1R,2R)-2-(Diphenylphosphino)-2,3-dihydro-1H-inden-1-amine, min. 97% (10wt% in THF)
CAS Registry Number: 1091606-70-0
Formula: C21H20NP
EINECS Number: none
Chemical Family: aminophosphine ligand
Synonym: (1R,2R)-2-(Diphenylphosphano)-2,3-dihydro-1H-inden-1-amine
Section 2: Composition and Information on Ingredients
Ingredient CAS Number Percent ACGIH (TWA) OSHA (PEL)
Title compound 1091606-70-0 10% no data no data
THF 109-99-9 90% 50ppm 590mg/m3
Section 3: Hazards Identification
Harmful if swallowed. Inhalation may cause dizziness, headache and shortness of breath. Irritating to skin,
Emergency Overview:
eyes and respiratory tract. Possible risk of harm to the unborn child.
Primary Routes of Exposure: Inhalation, skin, eyes
Eye Contact: Causes moderate irritation to the eyes.
Skin Contact: Causes moderate to severe irritation of the skin.
Harmful by inhalation. May cause coughing, headache and drowsiness. Irritating to the nose, mucous
Inhalation:
membranes and respiratory tract.
Ingestion: Harmful if swallowed. THF can cause liver damage.
Inhalation of vapors causes drowsiness. May cause chest pains, coughing, dizziness, headache and
Acute Health Affects:
unsciousness. Possible risk of harm to the unborn child. Irritating to skin and eyes.
Tetrahydrofuran is an eye and mucous membrane irritant and can cause liver and kidney damage. Possible
Chronic Health Affects:
risk of irreversible effects.
NTP: No
IARC: No
OSHA: No
SECTION 4: First Aid Measures
Immediately flush the eyes with copious amounts of water for at least 10-15 minutes. A victim may need
Eye Exposure:
assistance in keeping their eye lids open. Get immediate medical attention.
Wash the affected area with water. Remove contaminated clothes if necessary. Seek medical assistance if
Skin Exposure:
irritation persists.
Remove the victim to fresh air. Closely monitor the victim for signs of respiratory problems, such as difficulty
Inhalation:
in breathing, coughing, wheezing, or pain. In such cases seek immediate medical assistance.
Seek medical attention immediately. Keep the victim calm. Give the victim water (only if conscious). Induce
Ingestion:
vomiting only if directed by medical personnel.
SECTION 5: Fire Fighting Measures
Flash Point: 1F (THF)
Autoignition Temperature: 610F (THF)
Explosion Limits: 1.8% (LEL) 11.8% (UEL)
Extinguishing Medium: carbon dioxide, dry powder or foam
If this product is involved in a fire, fire fighters should be equipped with a NIOSH approved positive pressure
Special Fire Fighting Procedures:
self-contained breathing apparatus and full protective clothing.
Hazardous Combustion and If involved in a fire this material may emit irritating fumes.
Decomposion Products:
Unusual Fire or Explosion Hazards: Highly flammable material. Vapors can form explosive mixtures with air.
SECTION 6: Accidental Release Measures
Eliminate all potential spark sources. Small spills can be absorbed into vermiculite or other chemical adsorbent
Spill and Leak Procedures:
suitable for flammable materials. Sweep up the mixture and dispose of properly.
SECTION 7: Handling and Storage
Store in a tightly sealed container under an inert atmosphere of nitrogen or argon. Keep in a cool, dry, well
Handling and Storage:
ventilated place.
SECTION 8: Exposure Controls and Personal Protection
Eye Protection: Always wear approved safety glasses when handling a chemical substance in the laboratory.
Skin Protection: Wear protective clothing and gloves.
Ventilation: Handle the material in an efficient fume hood.
If ventilation is not available a respirator should be worn. The use of respirators requires a Respirator
Respirator:
Protection Program to be in compliance with 29 CFR 1910.134.
Ventilation: Handle the material in an efficient fume hood.
Additional Protection: No additional protection required.
SECTION 9: Physical and Chemical Properties
Color and Form: colorless to pale yellow liq.
Molecular Weight: 317.36
Melting Point: no data
Boiling Point: no data
Vapor Pressure: 160mm/Hg@25C(THF)
Specific Gravity: 0.89g/cm2 (THF)
Odor: ethereal
Solubility in Water: reacts with water
SECTION 10: Stability and Reactivity
Stability: air sensitive
Hazardous Polymerization: no hazardous polymerization
Conditions to Avoid: heat, ignition sources, contact with moisture
Incompatibility: water, oxidizing agents, halogens, air and mineral acids
Decomposition Products: carbon monoxide, carbon dioxide, nitrogen oxides, phosphorous oxides and organic fumes
SECTION 11: Toxicological Information
Title compound: No information available in the RTECS files. THF: Inhalation(human); TCLo: 25000ppm.
Oral(rat); LD50: 1650mg/kg. Inhalation(rat); LC50: 21000ppm/3H. Intraperitoneal(rat); LD50: 2900mg/kg.
RTECS Data:
Inhalation(mouse); LCLo: 24000mg/m3/2H. Inhalation(rabbit); LC: >1200ppm/4H. Oral(guinea pig); LDLo:
500mg/kg. Inhalation(rat); TCLo: 1800ppm/6H/2Y-1.
Carcinogenic Effects: THF: Data available
Mutagenic Effects: THF: Possible mutagen
Tetratogenic Effects: THF: Possible reproductive effector
SECTION 12: Ecological Information
Ecological Information: No information available
SECTION 13: Disposal Considerations
Disposal: Dispose of according to local, state and federal regulations.
SECTION 14: Transportation
Shipping Name (CFR): Flammable liquids, N.O.S.
Hazard Class (CFR): 3
Additional Hazard Class (CFR): NA
Packaging Group (CFR): I
UN ID Number (CFR): UN# 1993
Shipping Name (IATA): Flammable liquid, N.O.S.
Hazard Class (IATA): 3
Additional Hazard Class (IATA): NA
Packaging Group (IATA): I
UN ID Number (IATA): UN# 1993
SECTION 15: Regulatory Information
TSCA: Not listed in the TSCA inventory
SARA (Title 313): Not reportable under SARA 313.
Second Ingredient: Listed in the TSCA inventory. Not regulated under SARA
SECTION 16 - ADDITIONAL INFORMATION
N/A