双氢可待因
- 中文名称：
- 双氢可待因
- 中文别名：
- 双氢可待因;
油溶性茶多酚LTP
- 英文名称：
- DIHYDROCODEINE TRIFLUOROACETATE
- 英文别名：
- DIHYDROCODEINE TRIFLUOROACETATE;
Drocade;
Dihydrin;
Didrate;
Novcodin;
Drocode;
Dihydrocodein;
Dehacodin;
Nadeine;
dihydrocodeine;
Cohydrin;
Novicodin;
Parzone
- CAS No.：
- 125-28-0
- 分 子 式：
-
C20H24F3NO4
- 分 子 量：
- 399.4
- 精确分子量：
- 399.16600
- PSA：
- 59.00000
- EINECS：
- 204-732-3
- InChI：
- The Key: RBOXVHNMENFORY-DNJOTXNNSA-N3
- 风险术语：
- 11-23/24/25-39/23/24/25
- SDS：
- 查看
双氢可待因 物化性质
- 外观与性状：
- 白色结晶针状
- 密度：
- 1.31g/cm3
- 沸点：
- 462ºC at 760mmHg
- 闪点：
- 233.2ºC
- 折射率：
- 1.643
- 蒸汽压：
- 2.48E-09mmHg at 25°C
双氢可待因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD1680000
- CHEMICAL NAME :
- Morphinan-6-alpha-ol,
4,5-alpha-epoxy-3-methoxy-17-methyl-
- CAS REGISTRY NUMBER :
- 125-28-0
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C18-H23-N-O3
- MOLECULAR WEIGHT :
- 301.42
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN GHT&&TTJ FQ JO1 P1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 28 mg/kg
- TOXIC EFFECTS :
- Behavioral - sleep
Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
287,751,1983
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 6500 mg/kg/26W
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - miosis (pupillary constriction)
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,1594,1978
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 6 mg/kg/36H-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
1,211,1959
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 135 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 6,146,1951
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 6,146,1951
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig,
Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935
双氢可待因 下游产品
二氢可待因酮
[(4R,4aR,7S,7aR,12bS)-9-methoxy-3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-yl] pyridine-3-carboxylate