消旋啡烷
- 中文名称：
- 消旋啡烷
- 中文别名：
- 消旋啡烷;
Morphinan-3-ol,17-methyl-
- 英文名称：
- racemorphan
- 英文别名：
- 17-Methylmorphinan-3-ol;
racemorphan;
Cetarin;
Dromoran;
Nu-2206;
Racemethorphanum;
1,3,4,9,10,10A-Hexahydro-11-methyl-2H-10,4A-iminoethanophenanthren-6-ol, DL-mixture;
2H-10, 4A-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10A-hexahydro-11-methyl-, DL-;
Antalgin
- CAS No.：
- 297-90-5
- 分 子 式：
-
C17H23NO
- 分 子 量：
- 257.375
- 精确分子量：
- 257.17800
- PSA：
- 23.47000
- EINECS：
- 206-048-0
- InChI：
- The Key: JAQUASYNZVUNQP-USXIJHARSA-N3
- SDS：
- 查看
消旋啡烷 物化性质
- 密度：
- 1.17g/cm3
- 沸点：
- 410.4ºC at 760mmHg
- 闪点：
- 207.2ºC
- 折射率：
- 1.62
消旋啡烷 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QC9240000
- CHEMICAL NAME :
- Morphinan, 3-hydroxy-N-methyl-, (+-)-
- CAS REGISTRY NUMBER :
- 297-90-5
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C17-H23-N-O
- MOLECULAR WEIGHT :
- 257.41
- WISWESSER LINE NOTATION :
- T6 G666/FQ 2AF Q FX ONT&TTJ IQ O -R
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 350 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 3,238,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 385 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of
National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
Ont., Canada)
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 3,238,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 41 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg.,
2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
Volume(issue)/page/year: 4,105,1991
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 19 mg/kg
- TOXIC EFFECTS :
- Behavioral - analgesia
Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher
information, see NSAPCC. Volume(issue)/page/year: 216,48,1952