4-KETO全反式维甲酸
- 中文名称：
- 4-KETO全反式维甲酸
- 中文别名：
- 4-氧代-维A酸;
4-氧代-全反式维甲酸;
3,7-二甲基-9-(4-氧代-2,6,6-三甲基环己烯)-2,4,6,8-全反式壬四烯酸;
4-氧代-视黄酸;
维A酸-4-酮
- 英文名称：
- (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethyl-3-oxo-1-cyclohexenyl)nona-2,4,6,8-tetraenoic acid
- 英文别名：
- all-trans-4-oxoretinoic acid;
4-keto-Retinoic Acid;
4-oxo-all-rans-retinoic acid;
4-Oxoretinoic Acid;
all-trans-4-Oxoretinoic Acid;
4-oxo-all-trans-retinoic acid;
all-trans 4-Keto Retinoic Acid;
4-oxo-Retinoic acid;
4-Ketoretinoic Acid;
4-Oxo-atRA;
4-Oxotretinoin
- CAS No.：
- 38030-57-8
- 分 子 式：
-
C20H26O3
- 分 子 量：
- 0
- 精确分子量：
- 314.18800
- PSA：
- 54.37000
- InChI：
- The Key: GGCUJPCCTQNTJF-FRCNGJHJSA-N3
- SDS：
- 查看
4-KETO全反式维甲酸 物化性质
- 密度：
- 1.07g/cm3
- 熔点：
- 175-178°C (分解)
- 沸点：
- 509.9ºC at 760 mmHg
- 闪点：
- 276.3ºC
- 折射率：
- 1.565
4-KETO全反式维甲酸 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- VH6599800
- CHEMICAL NAME :
- Retinoic acid, 4-oxo-
- CAS REGISTRY NUMBER :
- 38030-57-8
- LAST UPDATED :
- 199007
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C20-H26-O3
- MOLECULAR WEIGHT :
- 314.46
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 100 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 35,33A,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 10 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
100,162,1989
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 20 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
95,122,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 39 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
95,122,1988
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 4900 ug/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - other developmental
abnormalities
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
95,122,1988