硝酸士的宁,66-32-0，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

表征图谱

硝酸士的宁

中文名称：: 硝酸士的宁

中文别名：: 硝酸士的宁;
士的宁硝酸盐

英文名称：: Strychnine Nitrate

英文别名：: STRYCHNINE NITRATE;
Strychnin-Nitrat;
strychnidin-10-one,mononitrate;
strychnidin-10-one,nitrate;
StrychnineHCL,(L-A046);
strychnine,mononitrate;
(-)-strychninium nitrate;
Strychninenitrate,(L-A044);
(-)-strychnine nitrate

CAS No.：: 66-32-0

分子式：: C₂₁H₂₂N₂O₂·HNO₂

分子量：: 397.43

精确分子量：: 397.16400

PSA：: 98.83000

MDL：: MFCD00078519

EINECS：: 200-627-1

InChI：: InChI=1/C21H22N2O2.NO3/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21;2-1(3)4/h1-5,13,16-17,19-20H,6-11H2;/q;-1/p+1/t13-,16?,17-,19-,20?,21+;/m0./s13

风险术语：: R26/27/28

安全术语：: S22 S45 S36/S37/S39

分子结构式：

SDS：: 查看

硝酸士的宁物化性质

沸点：: 634.3ºC at 760 mmHg
闪点：: 337.4ºC
存储条件/存储方法：: 库房低温,通风,干燥,与食品原料分开存放
其它信息：: 1.       性状：无色针状结晶或白色结晶性粉末。无气味。

2.       密度（g/mL,25/4℃）：未确定

3.       相对蒸汽密度（g/mL,空气=1）：未确定

4.       熔点（ºC）：未确定

5.       沸点（ºC,常压）：未确定

6.       沸点（ºC,5.2kPa）：未确定

7.       折射率：未确定

8.       闪点（ºC）：未确定

9.       比旋光度（º）：未确定

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（kPa,25ºC）：未确定

12.    饱和蒸气压（kPa,60ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：1g产品溶于42ml冷水、10ml沸水、150ml乙醇、80ml60℃的乙醇、105ml氯仿、50ml甘油，不溶于乙醚。pH约为5.7。剧毒！

硝酸士的宁安全信息

包装等级：
I

风险类别：
6.1(a)

WGK_Germany：
3
德国有关水污染物质的分类清单

危险类别码：
R26/27/28

安全说明：
S22-S36/37/39-S45

RTECS号：
WL2450000

安全标志：
S22:不要吸入粉尘。
S45:出现意外或者感到不适，立刻到医生那里寻求帮助（最好带去产品容器标签）。
:

危险标志：
T+: Very toxic;

硝酸士的宁毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WL2450000

CHEMICAL NAME :
Strychnine, mononitrate

CAS REGISTRY NUMBER :
66-32-0

LAST UPDATED :
199709

DATA ITEMS CITED :
14

MOLECULAR FORMULA :
C21-H22-N2-O2.H-N-O3

MOLECULAR WEIGHT :
397.47

WISWESSER LINE NOTATION :
T6 G656 B7 C6 E5 D 5ABCEF A& FX MNV QO VN SU AHT&&TTTTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Human

DOSE/DURATION :
500 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
16200 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,377,1982

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
3 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - tetany

REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 187,607,1937

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rat

DOSE/DURATION :
600 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
930 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 22,425,1984

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Subcutaneous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
2 mg/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 17,458,1967

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
600 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 20,1778,1970

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Unreported

SPECIES OBSERVED :
Rodent - mouse

DOSE/DURATION :
900 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 207,688,1949

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - dog

DOSE/DURATION :
1 gm/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - cat

DOSE/DURATION :
2 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - rabbit

DOSE/DURATION :
250 ug/kg

TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold

REFERENCE :
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 21,1,1958

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Oral

SPECIES OBSERVED :
Mammal - pig

DOSE/DURATION :
20 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950- Volume(issue)/page/year: 28,329,1977

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intravenous

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
1 mg/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928

TYPE OF TEST :
LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :
Intraarterial

SPECIES OBSERVED :
Rodent - guinea pig

DOSE/DURATION :
1200 ug/kg

TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 131,171,1928

毒理学数据：

急性毒性：人口经LDLo：500 ug/kg；大鼠口经LD50：16200 ug/kg；大鼠皮下注射LDLo：3 mg/kg；大鼠静脉LDLo：600 ug/kg；

硝酸士的宁 MSDS

Section I.Chemical Product and Company Identification
    Chemical Name Strychnine Nitrate
    Portland OR
    Synonym        Strychnine nitrate salt
    Chemical Formula        C21H22N2O2•HNO3
    66-32-0
    CAS Number

Section II.        Composition and Information on Ingredients
    Toxicology Data
    Chemical Name        CAS Number Percent (%)        TLV/PEL
    Strychnine Nitrate        66-32-0        Min. 99.0 (T) Not available.        Rat LD50 (oral) 16mg/kg
    Mouse LD50 (oral) 0.93mg/kg
    Rabbit LD50 (intravenous)
    0.25mg/kg

Section III. Hazards Identification
    Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
    Acute Health Effects
    death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    CARCINOGENIC EFFECTS : Not available.
    Chronic Health Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
    organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
    accumulation in one or many human organs.

Section IV.        First Aid Measures
    Eye Contact        Check for and remove any contact lenses. DO NOT use an eye ointment. Flush eyes with running water for a minimum of 15
    minutes, occasionally lifting the upper and lower eyelids. Seek medical attention.
    Skin Contact        If the chemical gets spilled on a clothed portion of the body, remove the contaminated clothes as quickly as possible,
    protecting your own hands and body. Place the victim under a deluge shower. If the chemical touches the victim's exposed
    skin, such as the hands: Gently and thoroughly wash the contaminated skin with running water and non-abrasive soap. Be
    particularly careful to clean folds, crevices, creases and groin. Cover the irritated skin with an emollient. If irritation persists,
    seek medical attention. Wash any contaminated clothing before reusing.
    Inhalation        If the victim is not breathing, perform mouth-to-mouth resuscitation. Loosen tight clothing such as a collar, tie, belt or
    waistband. If breathing is difficult, oxygen can be administered. Seek medical attention if respiration problems do not
    improve.
    Ingestion        INDUCE VOMITING by sticking finger in throat. Lower the head so that the vomit will not reenter the mouth and throat.
    Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible indication that the toxic
    material was ingested; the absence of such signs, however, is not conclusive. SEEK IMMEDIATE MEDICAL ATTENTION in
    case of ingestion of a radioactive material.

Section V.        Fire and Explosion Data
    Not available.
    Flammability        Not available.        Auto-Ignition
    Not available.
    Flash Points        Not available.        Flammable Limits
    Combustion Products        These products include toxic carbon oxides (CO,CO2), nitrogen oxides (NO, NO2).
    Fire Hazards
    No specific information is available regarding the flammability of this compound in the presence of various materials.
    Explosion Hazards        Risks of explosion of the product in presence of mechanical impact: Not available.
    Risks of explosion of the product in presence of static discharge: Not available.
    No additional information is available regarding the risks of explosion.
    Fire Fighting Media        SMALL FIRE: Use DRY chemicals, CO2, water spray or foam.
    LARGE FIRE: Use water spray, fog or foam. DO NOT use water jet.
    and Instructions
    Consult with local fire authorities before attempting large scale fire-fighting operations.
    Continued on Next Page
    Strychnine Nitrate

Section VI.        Accidental Release Measures
    Spill Cleanup        Highly toxic material.
    Stop leak if without risk. DO NOT get water inside container. DO NOT touch spilled material. Use water spray to reduce
    Instructions
    assistance on disposal.

Section VII. Handling and Storage
    HIGHLY TOXIC COMPOUND. Keep locked up. LIGHT SENSITIVE--store in a darkened cabinet or closet. Keep away from
    Handling and Storage
    heat and sources of ignition. Empty containers pose a fire risk, evaporate the residue under a fume hood. Ground all
    Information
    equipment containing material. DO NOT ingest. DO NOT breathe dust. In case of insufficient ventilation, wear suitable
    respiratory equipment. If ingested, seek medical advice immediately and show the container or the label. Avoid contact with
    skin and eyes.
    Always store away from incompatible compounds such as oxidizing agents, alkalis, alkali carbonates and bicarbonates,
    benzoates, dichromates, bromides, iodides, tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine.

Section VIII. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended
    exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to airborne contaminants
    below the exposure limit.
    Splash goggles. Lab coat. Dust respirator. Boots. Gloves. A MSHA/NIOSH approved respirator should be used to avoid
    Personal Protection
    inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist BEFORE handling this
    product.
    Not available.
    Exposure Limits

Section IX. Physical and Chemical Properties
    Physical state @ 20°C        Solid. (Powder.)        Solubility
    Soluble in water, ethanol, chloroform,
    glycerol.
    Not available.        Insoluble in ether.
    Specific Gravity
    Molecular Weight        397.43        Partition Coefficient        Not available.
    Boiling Point        Not available.        Vapor Pressure        Not available.
    Not available.        Not available.
    Melting Point        Vapor Density
    Refractive Index        Not available.        Volatility        Not available.
    Not available.        Odorless.
    Critical Temperature        Odor
    Not available.        Not available.
    Viscosity        Taste

Section X.        Stability and Reactivity Data

This material is stable if stored under proper conditions. (See Section VII for instructions)
    Stability
    Conditions of Instability        LIGHT SENSITIVE.
    Incompatibilities
    Highly reactive with oxidizing agents, alkalis, alkali carbonates and bicarbonates, benzoates, dichromates, bromides, iodides,
    tannic and picric acids, salicyclates, borax, gold chlorides, and piperazine. .

Section XI. Toxicological Information
    WL2450000
    RTECS Number
    Ingestion. Inhalation. Eye contact. Skin contact.
    Routes of Exposure
    Rat LD50 (oral) 16mg/kg
    Toxicity Data
    Mouse LD50 (oral) 0.93mg/kg
    Rabbit LD50 (intravenous) 0.25mg/kg
    CARCINOGENIC EFFECTS : Not available.
    Chronic Toxic Effects
    MUTAGENIC EFFECTS : Not available.
    TERATOGENIC EFFECTS : Not available.
    Toxicity to the reproductive system: Not available. Repeated or prolonged exposure to the substance can produce target
    organs damage. Repeated exposure to an highly toxic material may produce general deterioration of health by an
    accumulation in one or many human organs.
    Highly toxic if ingested or inhaled. Avoid prolonged contact with this material. Overexposure may result in serious illness or
    Acute Toxic Effects
    death. Follow safe industrial hygiene practices and always wear proper protective equipment when handling this compound.
    Continued on Next Page
    Strychnine Nitrate

Section XII.        Ecological Information
    Ecotoxicity        Not available.
    Not available.
    Environmental Fate

Section XIII. Disposal Considerations
    Recycle to process, if possible. Consult your local or regional authorities. You may be able to dissolve or mix material with a
    Waste Disposal
    combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all
    federal, state, and local regulations when disposing of this substance.

Section XIV. Transport Information
    DOT Classification        DOT CLASS 6.1: Poisonous material.
    PIN Number
    Proper Shipping Name        Strychnine salts.
    I
    Packing Group (PG)
    DOT Pictograms

Section XV. Other Regulatory Information and Pictograms
    TSCA Chemical Inventory        This product is NOT on the EPA Toxic Substances Control Act (TSCA) inventory. The following notices are required by 40
    CFR 720.36 (C) for those products not on the inventory list:
    (EPA)
    (i) These products are supplied solely for use in research and development by or under the supervision of a technically
    qualified individual as defined in 40 CFR 720.0 et sec.
    (ii) The health risks of these products have not been fully determined. Any information that is or becomes available will be
    supplied on an MSDS sheet.
    WHMIS Classification        WHMIS CLASS D-1A: Material causing immediate and serious toxic effects (VERY TOXIC).
    (Canada)
    EINECS Number (EEC) 200-627-1
    EEC Risk Statements        R26/27/28- Very toxic by inhalation, in contact with skin and if swallowed.

SECTION 16 - ADDITIONAL INFORMATION
N/A

硝酸士的宁分子结构与计算化学数据

计算化学数据

1、   氢键供体数量：1

2、   氢键受体数量：5

3、   可旋转化学键数量：0

4、   拓扑分子极性表面积（TPSA）：100

5、   重原子数量：29

6、   表面电荷：0

7、   复杂度：708

8、   同位素原子数量：0

9、   确定原子立构中心数量：4

10、   不确定原子立构中心数量：2

11、   确定化学键立构中心数量：0

12、   不确定化学键立构中心数量：0

13、   共价键单元数量：2

硝酸士的宁表征图谱

硝酸士的宁红外图谱(IR1)

硝酸士的宁红外图谱(IR2)

硝酸士的宁核磁图(¹³CNMR)

硝酸士的宁核磁图(¹HNMR)

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硝酸士的宁

硝酸士的宁制备方法及用途

制备方法

用途简介

用途

硝酸士的宁物化性质

硝酸士的宁安全信息

硝酸士的宁毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硝酸士的宁 MSDS

硝酸士的宁分子结构与计算化学数据

计算化学数据

硝酸士的宁表征图谱

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硝酸士的宁

硝酸士的宁 制备方法及用途

制备方法

用途简介

用途

硝酸士的宁 物化性质

硝酸士的宁 安全信息

硝酸士的宁 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

硝酸士的宁 MSDS

硝酸士的宁 分子结构与计算化学数据

计算化学数据

硝酸士的宁 表征图谱

推荐供应商

硝酸士的宁制备方法及用途

硝酸士的宁物化性质

硝酸士的宁安全信息

硝酸士的宁毒理性

硝酸士的宁分子结构与计算化学数据

硝酸士的宁表征图谱