福尔可定
- 中文名称：
- 福尔可定
- 中文别名：
- 福尔可定
- 英文名称：
- PHOLCODINE
- 英文别名：
- pholcodine;
3-(2-(4-Morpholinyl)ethyl)morphine;
PHOLCODINE;
3-Morpholylaethylmorphin;
Folcodina;
3-morpholinoethylmorphine;
Pholcodinum;
(5R,6S)-4,5-epoxy-N-methyl-3-(2-morpholinoethoxy)morphin-7-en-6-ol;
(4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;
Morpholinylethylmorphine;
3-(2-Morpholinoethyl)morphine
- CAS No.：
- 509-67-1
- 分 子 式：
-
C23H30N2O4
- 分 子 量：
- 398.5
- 精确分子量：
- 398.22100
- PSA：
- 54.40000
- EINECS：
- 208-102-9
- InChI：
- The Key: GPFAJKDEDBRFOS-YNWHNULJSA-N3
- SDS：
- 查看
福尔可定 物化性质
- 密度：
- 1.34g/cm3
- 沸点：
- 577.8ºC at 760mmHg
- 闪点：
- 303.2ºC
- 折射率：
- 1.659
福尔可定 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- QD1575000
- CHEMICAL NAME :
- Morphinan-6-alpha-ol,
7,8-didehydro-4,5-alpha-epoxy-17-methyl-3-(2-morpholi
noethoxy)-
- CAS REGISTRY NUMBER :
- 509-67-1
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C23-H30-N2-O4
- MOLECULAR WEIGHT :
- 398.55
- WISWESSER LINE NOTATION :
- T B6566 B6/CO 4ABBC R BX HO PN DU GHT&&TTJ FQ P1 JO2-
AT6N DOTJ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku,
Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952-
Volume(issue)/page/year: 12,89,1963
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 7,21,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 540 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,325,1958
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 230 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris,
France) V.1- 1946- Volume(issue)/page/year: 7,21,1952
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
Behavioral - excitement
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 8,325,1958