氯曲芬
- 中文名称：
- 氯曲芬
- 中文别名：
- 氯曲芬
- 英文名称：
- lotrifen
- 英文别名：
- lotrifen;
2-(4-chloro-phenyl)-[1,2,4]triazolo[5,1-a]isoquinoline;
2-(p-Chlorophenyl)-s-triazolo[5,1-a]isoquinoline;
Privaprol;
Canocenta;
DL-7171T
- CAS No.：
- 66535-86-2
- 分 子 式：
-
C16H10ClN3
- 分 子 量：
- 279.729
- 精确分子量：
- 279.05600
- PSA：
- 30.19000
- EINECS：
- 266-394-3
- InChI：
- The Key: DGWUVKLBXCWNTA-UHFFFAOYSA-N3
- SDS：
- 查看
氯曲芬 物化性质
- 密度：
- 1.36g/cm3
- 折射率：
- 1.714
氯曲芬 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XZ5478400
- CHEMICAL NAME :
- s-Triazolo(5,1-a)isoquinoline, 2-(p-chlorophenyl)-
- CAS REGISTRY NUMBER :
- 66535-86-2
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C16-H10-Cl-N3
- MOLECULAR WEIGHT :
- 279.74
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - tremor
Behavioral - ataxia
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 4500 ug/kg
- SEX/DURATION :
- female 7 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 2500 ug/kg
- SEX/DURATION :
- female 4-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- MDACAP Medicamentos de Actualidad. (J.R. Prous, S.A., Apartado de Correos
540, 08080 Barcelona, Spain) V.1- 1965- Volume(issue)/page/year:
23,75,1987
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- JAPRAN Journal of Small Animal Practice. (Biochemical Soc. Book Depot, POB
32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
Volume(issue)/page/year: 23,295,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intramuscular
- DOSE :
- 500 ug/kg
- SEX/DURATION :
- female 20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 4-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 40 mg/kg
- SEX/DURATION :
- female 4-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255
Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year:
5,55,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 70 ug/kg
- SEX/DURATION :
- female 4 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 125 ug/kg
- SEX/DURATION :
- female 4-8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
- REFERENCE :
- JOPHDQ Journal of Pharmacobio-Dynamics. (Japan Pub. Trading Co. (USA), 1255
Howard St., San Francisco, CA 94103) V.1- 1978- Volume(issue)/page/year:
5,55,1982
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 15 mg/kg
- SEX/DURATION :
- female 4-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility
- REFERENCE :
- RDMIDP Quarterly Reviews on Drug Metabolism and Drug Interactions. (Freund
Pub. House, Suite 500, Chesham House, 150 Regent St., London W1R 5FA, UK)
V.3- 1980- Volume(issue)/page/year: 4,237,1982
氯曲芬 海关数据
中国海关编码：2933990090
- 概述：
- 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
- 申报要素：
- 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
- 摘要/Summary：
- 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%