螺铂
- 中文名称：
- 螺铂
- 中文别名：
- 螺铂;
顺螺铂
- 英文名称：
- [cyclohexane-1,1-diylbis(methylamine)-N,N][sulphato(2-)-O,O]platinum
- 英文别名：
- [cyclohexane-1,1-diylbis(methylamine)-N,N'][sulphato(2-)-O,O']platinum;
Spiroplatin
- CAS No.：
- 74790-08-2
- 分 子 式：
-
C8H18N2.O4S.Pt
- 分 子 量：
- 433.386
- 精确分子量：
- 433.06400
- PSA：
- 140.68000
- EINECS：
- 277-997-6
- InChI：
- The Key: XASGSSXPZXRXFL-UHFFFAOYSA-L3
- SDS：
- 查看
螺铂 物化性质
- 沸点：
- 198.8ºC at 760 mmHg
- 闪点：
- 83.9ºC
螺铂 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TP2283000
- CHEMICAL NAME :
- Platinum,
(1,1-cyclohexanedimethanamine-N,N')(sulfato(2-)-O,O')
-, (SP-4-2)-
- CAS REGISTRY NUMBER :
- 74790-08-2
- LAST UPDATED :
- 199601
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C8-H18-N2-O4-Pt-S
- MOLECULAR WEIGHT :
- 433.43
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 8900 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 3 mg/kg/9W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - proteinuria
Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
MUTATION DATA
- TYPE OF TEST :
- Morphological transformation
- TEST SYSTEM :
- Rodent - hamster Kidney
- DOSE/DURATION :
- 1500 nmol/L
- REFERENCE :
- EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press,
c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)-
25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year:
25,27,1989