Section 1. Chemical Product and Company Identification
Morphine sulfate
Common Name/
Trade Name
Morphine sulfate
Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at
least 15 minutes. Cold water may be used. Get medical attention if irritation occurs.
Skin Contact Wash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops.
Cold water may be used.
Serious Skin Contact Not available.
Inhalation If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get
medical attention.
Serious Inhalation Not available.
Ingestion Do NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight
clothing such as a collar, tie, belt or waistband.
Serious Ingestion Not available.
Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...), sulfur oxides (SO2, SO3...).
Products of Combustion
Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
Various Substances Non-flammable in presence of shocks.
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Slightly explosive in presence of open flames and sparks.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on As with most organic solids, fire is possible at elevated temperatures or by contact with an ignition source.
Fire Hazards
Special Remarks on Explosion Fine dust dispersed in air in sufficient concentrations, and in the presences of an ignition source is a potential dust
Hazards explosion hazard.
Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Morphine sulfate
Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust.
Wear suitable protective clothing. In case of insufficient ventilation, wear suitable respiratory equipment. If
ingested, seek medical advice immediately and show the container or the label. Keep away from incompatibles
such as oxidizing agents, alkalis.
Storage Keep container tightly closed. Keep container in a cool, well-ventilated area.
Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Safety glasses. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent. Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.
Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powdered solid.) Odor Odorless.
Not available.
Taste
Molecular Weight 758.85 g/mole
White.
Color
Not available.
pH (1% soln/water)
Boiling Point Not available.
250°C (482°F)
Melting Point
Critical Temperature Not available.
Specific Gravity Not available.
Vapor Pressure Not applicable.
Vapor Density Not available.
Not available.
Volatility
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Ionicity (in Water) Not available.
Dispersion Properties See solubility in water.
Solubility Soluble in cold water.
Section 10. Stability and Reactivity Data
Stability The product is stable.
Instability Temperature Not available.
Conditions of Instability Excessive heat, incompatible materials
Incompatibility with various Reactive with oxidizing agents, alkalis.
substances
Morphine sulfate
Corrosivity Non-corrosive in presence of glass.
Special Remarks on Incompatible with alkalies, tannic acid, iodic acid, potassium permanganate, borax, chlorates, ferric chloride,
Reactivity iodides, lead acetate, magnesia, spirit nitrous ether, mercury bichloride, and gold salts. Sensitive to light.
Special Remarks on Not available.
Corrosivity
Polymerization Will not occur.
Section 11. Toxicological Information
Routes of Entry Inhalation. Ingestion.
Toxicity to Animals Acute oral toxicity (LD50): 973 mg/kg [Rat].
Chronic Effects on Humans May cause damage to the following organs: central nervous system (CNS).
Other Toxic Effects on Hazardous in case of ingestion, of inhalation.
Humans Slightly hazardous in case of skin contact (irritant, permeator).
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on May cause adverse reproductive effects and birth defects (teratogenic). May affect genetic material (mutagenic)
Chronic Effects on Humans Human: passes through the placenta, excreted in maternal milk.
Special Remarks on other Acute Potential Health Effects:
Toxic Effects on Humans Skin: May cause slight irritation. May be absorbed through broken or inflammed skin.
Eyes: May cause slight eye irritation.
Inhalation: May cause respiratory tract and mucous membrane irritaiton with sneezing and/or coughing. Inhalation
of large quantities may cause lung edema, respiratory difficulties, dizziness, and have an anesthetic effect
(symptoms similar to ingestion).
Ingestion: Narcotic! May Be Habit Forming! It may cause gastrointestinal tract irritaiton (disturbances) with
nausea, vomiting, constipation. Ingestion of large amounts may affect behavior/central nervous system
(drowsiness, dizziness, slurred speech, somnolence, mental exhilaration, confusion, mood changes,
restlessness), metabolism (anorexia), cardiovascular system (heart palpitations, low blood pressure, hypertension,
arrhythmias, acute ventricular failrue, bradycardia, cardia arrest). Other symptoms may include dry mouth,
sweating, facila flushing, rash, non-responsive contracted pupils, and hypothermia, labored breathing causing
cyanosis, flaccid skeletal muscles. Pneumonia, pulmonary edema, shock, coma, and even death may occur in
severe cases.
Chronic Potential Health Effects:
Inhalation: Prolonged or repeated inhalation may cause respiratory irritation, tightness of the chest, asthma, and
bronchitis.
Ingestion: Prolonged or repeated ingestion may cause habituation or addiction. It may affect the blood, urinary
system , and metabolism (anorexia).
Skin: May cause contact dermatitis in sensitized indivduals
Sensitive individuals may also develop anaphylatic (allergic) reactions upon re-exposure by inhalation or ingestion.
Section 12. Ecological Information
Not available.
Ecotoxicity
Not available.
BOD5 and COD
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are less toxic than the product itself.
of Biodegradation
Not available.
Special Remarks on the
Products of Biodegradation
Morphine sulfate
Section 13. Disposal Considerations
Waste Disposal Waste must be disposed of in accordance with federal, state and local environmental
control regulations.
Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Not applicable.
Identification
Not applicable.
Special Provisions for
Transport
DOT (Pictograms)
Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California
Proposition 65
Warnings
Other Regulations Morphine Sulfate (CAS no. 64-31-3) is on the Canadian Domestic Substances list.
Morphine Sulfate Pentahydrate (CAS no. 6211-15-0) is not in the Canadian Domestic Substances list.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) R22- Harmful if swallowed. S2- Keep out of the reach of children.
S46- If swallowed, seek medical advice
immediately and show this container or label.
Health Hazard
HMIS (U.S.A.) 1 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
Morphine sulfate
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
SECTION 16 - ADDITIONAL INFORMATION
N/A