制备方法

有机合成。

用途简介

用途

有机合成。

海关代码：

2921300090

危险类别码：

R20/21/22;R36/37/38

安全说明：

S36/37/39-S26

RTECS号：

GX1440000

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:

危险标志：

Xn:Harmful;

CHEMICAL IDENTIFICATION

RTECS NUMBER :

GX1440000

CHEMICAL NAME :

Cyclohexylamine, hydrochloride

CAS REGISTRY NUMBER :

4998-76-9

LAST UPDATED :

199712

DATA ITEMS CITED :

19

MOLECULAR FORMULA :

C6-H13-N.Cl-H

MOLECULAR WEIGHT :

135.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

720 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Behavioral - coma

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

350 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - lacrimation Gastrointestinal - changes in structure or function of salivary glands Skin and Appendages - hair

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

760 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Behavioral - coma

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

300 mg/kg

TOXIC EFFECTS :

Behavioral - excitement Gastrointestinal - changes in structure or function of salivary glands Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

200 mg/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Cardiac - pulse rate increase, without fall in BP

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - guinea pig

DOSE/DURATION :

520 mg/kg

TOXIC EFFECTS :

Behavioral - muscle weakness Behavioral - muscle contraction or spasticity Behavioral - coma

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

432 mg/kg/30D-I

TOXIC EFFECTS :

Blood - normocytic anemia Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

219 gm/kg/2Y-C

TOXIC EFFECTS :

Behavioral - food intake (animal) Kidney, Ureter, Bladder - changes in bladder weight Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

9100 mg/kg/13W-C

TOXIC EFFECTS :

Behavioral - fluid intake Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in ovarian weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

45 gm/kg/13W-C

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - changes in testicular weight

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

32400 mg/kg

SEX/DURATION :

male 90 day(s) pre-mating

TOXIC EFFECTS :

Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1 gm/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1 gm/kg

SEX/DURATION :

female 6-15 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

TYPE OF TEST :

Sperm Morphology

MUTATION DATA

TEST SYSTEM :

Rodent - hamster

DOSE/DURATION :

600 mg/kg/3D (Continuous)

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 13,415,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5404 No. of Facilities: 4290 (estimated) No. of Industries: 48 No. of Occupations: 43 No. of Employees: 53611 (estimated) No. of Female Employees: 16742 (estimated)

毒理学数据：

主要的刺激性影响

在皮肤上面：刺激皮肤和粘膜

   在眼睛上面：刺激的影响

   致敏作用：没有已知的敏化影响

生态数据：

通常对水是不危害的，若无政府许可，勿将材料排入周围环境

中国海关编码：2921300090

概述：

2921300090 其他环（烷，烯，萜烯）单胺或多胺（包括其衍生物及它们的盐）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

分子结构数据

1、   摩尔折射率：31.22

2、   摩尔体积（m³/mol）：114.0

3、   等张比容（90.2K）：270.1

4、   表面张力（dyne/cm）：31.4

5、   极化率（10^-24cm³）：12.37

计算化学数据

1、  氢键供体数量：2

2、  氢键受体数量：1

3、  可旋转化学键数量：0

4、  拓扑分子极性表面积（TPSA）：26

5、  重原子数量：8

6、  表面电荷：0

7、  复杂度：46.1

8、  同位素原子数量：0

9、  确定原子立构中心数量：0

10、 不确定原子立构中心数量：1

11、 确定化学键立构中心数量：0

12、 不确定化学键立构中心数量：0

13、 共价键单元数量：2

• 
  环己胺盐酸盐红外图谱(IR1)
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  环己胺盐酸盐红外图谱(IR2)
• 
  环己胺盐酸盐质谱(MS)
• 
  环己胺盐酸盐核磁图(¹³CNMR)
• 
  环己胺盐酸盐Raman光谱
• 
  环己胺盐酸盐核磁图(¹HNMR)