丙泮尼地
- 中文名称：
- 丙泮尼地
- 中文别名：
- 丙泮尼地;
普尔安
- 英文名称：
- Benzeneacetic acid,4-[2-(diethylamino)-2-oxoethoxy]-3-methoxy-, propyl ester
- 英文别名：
- propyl 2-[4-[2-(diethylamino)-2-oxoethoxy]-3-methoxyphenyl]acetate;
Epontol;
Sombrevin;
Bayer 1420;
Propantan;
Fabontal;
Fabantol;
Propanidid;
propanidide
- CAS No.：
- 1421-14-3
- 分 子 式：
-
C18H27NO5
- 分 子 量：
- 337.41068
- 精确分子量：
- 337.18900
- PSA：
- 65.07000
- EINECS：
- 215-822-7
- InChI：
- The Key: KEJXLQUPYHWCNM-UHFFFAOYSA-N3
- 分子结构式：
-
- SDS：
- 查看
丙泮尼地 物化性质
- 密度：
- 1.087g/cm3
- 沸点：
- 459.7ºC at 760mmHg
- 闪点：
- 231.8ºC
- 折射率：
- 1.503
- 蒸汽压：
- 1.24E-08mmHg at 25°C
丙泮尼地 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- AG9625000
- CHEMICAL NAME :
- Acetic acid,
(4-((diethylcarbamoyl)methoxy)-3-methoxyphenyl)-,
propyl ester
- CAS REGISTRY NUMBER :
- 1421-14-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 8
- MOLECULAR FORMULA :
- C18-H27-N-O5
- MOLECULAR WEIGHT :
- 337.46
- WISWESSER LINE NOTATION :
- 3OV1R CO1 DO1VN2&2
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 5 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic
Biochemical - Metabolism (Intermediary) - histamines (including liberation
not immunochemical in origin)
- REFERENCE :
- BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1923- Volume(issue)/page/year:
45,1097,1973
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 81 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959-
Volume(issue)/page/year: 17,21,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 113 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180,
Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 19,845,1980
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959-
Volume(issue)/page/year: 17,21,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 80 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959-
Volume(issue)/page/year: 17,21,1965
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AASXAP Acta Anaesthesiologica Scandinavica, Supplementum. (Munksgaard
International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1959-
Volume(issue)/page/year: 17,21,1965
** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- DOSE :
- 1200 mg/kg
- SEX/DURATION :
- female 1-60 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
Reproductive - Specific Developmental Abnormalities - urogenital system
Reproductive - Effects on Newborn - physical
- REFERENCE :
- NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of
New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
Volume(issue)/page/year: 64,2177,1964
丙泮尼地 海关数据
中国海关编码：2924299090
- 概述：
- 2924299090. 其他环酰胺（包括环氨基甲酸酯）（包括其衍生物以及他们的盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%
- 申报要素：
- 品名, 成分含量, 用途, 包装
- 摘要/Summary：
- 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
