氯化苦,76-06-2，生产厂家，价格-洛克化工网移动版

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基本信息

制备方法及用途

物化性质

安全信息

毒理性

MSDS

结构与计算化学

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氯化苦

中文名称：: 氯化苦

中文别名：: 氯化苦;
硝基氯仿;
三氯硝基甲烷;
三氯硝基甲烷/硝基三氯甲烷

英文名称：: Trichloronitromethane

英文别名：: chloropicrin;
trichloronitromethane;
Dolochlor;
Trichlor-nitro-methan;
trichloro(nitro)methane;
Larvacide;
Dojyopicrin;
Nitrochloroform;
trichloro-nitro-methane;
Chloropicrin;
Nitrotrichloromethane;
Chlorpikrin;
Chloropicrine

CAS No.：: 76-06-2

分子式：: CCl3NO2

分子量：: 164.38

精确分子量：: 162.89900

PSA：: 45.82000

MDL：: MFCD00041878

EINECS：: 200-930-9

BRN：: 1756135

InChI：: InChI=1/CCl3NO2/c2-1(3,4)5(6)73

风险术语：: R22;R26;R36/37/38

SDS：: 查看

氯化苦毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: PB6300000

CHEMICAL NAME :: Methane, trichloronitro-

CAS REGISTRY NUMBER :: 76-06-2

BEILSTEIN REFERENCE NO. :: 1756135

LAST UPDATED :: 199712

DATA ITEMS CITED :: 48

MOLECULAR FORMULA :: C-Cl3-N-O2

MOLECULAR WEIGHT :: 164.37

WISWESSER LINE NOTATION :: WNXGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2 mg/m3

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Sense Organs and Special Senses (Eye) - conjunctive irritation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Human

DOSE/DURATION :: 2000 mg/m3/10M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 14400 ppb/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 66 mg/m3/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - increased intraocular pressure Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 25 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 800 mg/m3/20M

TOXIC EFFECTS :: Behavioral - food intake (animal) Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 800 mg/m3/20M

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LCLo - Lowest published lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 800 mg/m3/20M

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - emphysema Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 4200 ug/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - acute pulmonary edema

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg/10D-I

TOXIC EFFECTS :: Endocrine - changes in thymus weight Blood - changes in leukocyte (WBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2880 mg/kg/90D-I

TOXIC EFFECTS :: Gastrointestinal - other changes Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 gm/kg/78W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

REFERENCE :: TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980- Volume(issue)/page/year: 10,21,1990 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.67 mg/m3 (0.1 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 0.1 ppm (0.7 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,54,1971 OSHA PEL (Gen Indu):8H TWA 0.1 ppm (0.7 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 0.1 ppm (0.7 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 0.1 ppm (0.7 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 0.1 ppm (0.7 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-BELGIUM:TWA 0.1 ppm (0.67 mg/m3);STEL 0.3 ppm (2 mg/m3) JAN 1993 OEL-DENMARK:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm (2.1 mg/m3) JAN 1993 OEL-FRANCE:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-GERMANY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-JAPAN:TWA 0.1 ppm (0.67 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-RUSSIA:TWA 0.1 ppm JAN 1993 OEL-SWITZERLAND:TWA 0.1 ppm (0.7 mg/m3);STEL 0.2 ppm (1.4 mg/m3) JAN 1993 OEL-TURKEY:TWA 0.1 ppm (0.7 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 ppm (0.7 mg/m3);STEL 0.3 ppm JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CHLOROPICRIN-air:10H TWA 0.1 ppm REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0419 No. of Facilities: 484 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 4843 (estimated) No. of Female Employees: 939 (estimated)

毒理学数据：

1.急性毒性^[9] LD50：126~271mg/kg（小鼠经口）

2.刺激性 暂无资料

3.致突变性^[10] 微生物致突变：鼠伤寒沙门菌50μg/皿、大肠杆菌50μg/皿。姐妹染色单体交换：人淋巴细胞8mg/L。

生态数据：

1.生态毒性 暂无资料

2.生物降解性 暂无资料

3.非生物降解性 暂无资料

氯化苦 MSDS

国标编号:	61051
ＣＡＳ:	76-06-2
中文名称:	三氯硝基甲烷
英文名称:	nitrotrichloromethane；chloropicrin
别名:	氯化苦；硝基三氯甲烷
分子式:	CCl₃NO₂
分子量:	164.39
熔点:	-64℃ 沸点：112℃
密度:	相对密度(水=1)1.69
蒸汽压:
溶解性:	不溶于水，溶于乙醇、苯等多数有机溶剂
稳定性:	稳定
外观与性状:	无色或微黄色油状液体，有催泪性
危险标记:	13(剧毒品)
用途:	用于有机合成用作杀虫剂

2.对环境的影响:
一、健康危害
侵入途径：吸入、食入、经皮吸收。
健康危害：蒸气强烈刺激眼和肺，具有全身毒作用。损害中、小支气管，导致中毒性肺炎和肺水肿。
急性中毒：出现眼与咽喉部刺激症状、头痛、恶心、呕吐、腹痛、呼吸困难、心悸、气促、胸部紧束感等。严重者发生肺水肿，往往由于肺水肿而致死。可引起角膜炎和虹膜炎。皮肤接触可致灼伤。
二、毒理学资料及环境行为
毒性：属中等毒性。
急性毒性：LD₅₀126～271mg/kg(小鼠经口)；LC119ppm，30分钟(人吸入)；猫吸入510mg/m³×25分钟，通常1天内死亡；人吸入5mg/m³，眼刺激症状；人吸入7.5ppm×10分钟，可耐受。
刺激性：家兔经眼：500mg(24小时)，轻度刺激。家兔经皮：500mg(24小时)，轻度刺激。
危险特性：其蒸气沿地面扩散，有毒。遇发烟硫酸可分解产生光气。
燃烧(分解)产物：氯化氢、氧化氮、一氧化碳、二氧化碳。

3.现场应急监测方法:

气体检测管法

4.实验室监测方法:

盐酸萘乙二胺比色法《空气中有害物质的测定方法》(第二版)杭士平主编
气相色谱法(粮食)《农药残留量气相色谱法》国家商检局编

5.环境标准:

中国(TJ36-79)	车间空气中有害物质的最高容许浓度	1mg/m³
前苏联(1978)	环境空气中最高容许浓度	0.01mg/m³
	嗅觉阈浓度	1.1ppm

6.应急处理处置方法:

一、泄漏应急处理
迅速撤离泄漏污染区人员至安全区，并立即隔离150米，严格限制出入。建议应急处理人员戴自给正压式呼吸器，穿防毒服。不要直接接触泄漏物。尽可能切断泄漏源。防止进入下水道、排洪沟等限制性空间。小量泄漏：用砂土或其它不燃材料吸附或吸收。大量泄漏：构筑围堤或挖坑收容；用泡沫覆盖，降低蒸气灾害。用泵转移至槽车或专用收集器内，回收或运至废物处理场所处置。
二、防护措施
呼吸系统防护：可能接触其蒸气时，必须佩戴自吸过滤式防毒面具(全面罩)。紧急事态抢救或撤离时，建议佩戴自给式呼吸器。
眼睛防护：呼吸系统防护中已作防护。
身体防护：穿防毒服。
手防护：戴橡胶手套。
其它：工作现场禁止吸烟、进食和饮水。工作毕，彻底清洗。工作服不准带至非作业场所。单独存放被毒物污染的衣服，洗后备用。
三、急救措施
皮肤接触：立即脱去被污染的衣着，用大量流动清水冲洗，至少15分钟。就医。
眼睛接触：立即提起眼睑，用大量流动清水或生理盐水彻底冲洗至少15分钟。就医。
吸入：迅速脱离现场至空气新鲜处。保持呼吸道通畅。如呼吸困难，给输氧。如呼吸停止，立即进行人工呼吸。就医。
食入：饮足量温水，催吐，就医。
灭火方法：消防人员须佩戴防毒面具、穿全身消防服。灭火剂：雾状水、泡沫、二氧化碳、砂土。

氯化苦

氯化苦制备方法及用途

制备方法

合成制备方法

用途简介

用途

氯化苦物化性质

氯化苦安全信息

氯化苦毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

氯化苦 MSDS

3.现场应急监测方法:

4.实验室监测方法:

5.环境标准:

6.应急处理处置方法:

氯化苦分子结构与计算化学数据

分子结构数据

计算化学数据

氯化苦上游产品

氯化苦下游产品

推荐供应商

氯化苦

氯化苦 制备方法及用途

制备方法

合成制备方法

用途简介

用途

氯化苦 物化性质

氯化苦 安全信息

氯化苦 毒理性

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

氯化苦 MSDS

3.现场应急监测方法:

4.实验室监测方法:

5.环境标准:

6.应急处理处置方法:

氯化苦 分子结构与计算化学数据

分子结构数据

计算化学数据

氯化苦 上游产品

氯化苦 下游产品

推荐供应商

氯化苦制备方法及用途

氯化苦物化性质

氯化苦安全信息

氯化苦毒理性

氯化苦分子结构与计算化学数据

氯化苦上游产品

氯化苦下游产品