盐酸依替卡因
- 中文名称：
- 盐酸依替卡因
- 中文别名：
-
- 英文名称：
- ()-N-(2,6-dimethylphenyl)-2-(ethylpropylamino)butyramide monohydrochloride
- 英文别名：
- N-(2,6-dimethylphenyl)-2-[ethyl(propyl)amino]butanamide,hydrochloride;
Duranest Hydrochloride;
Etidocaine HCl;
Etidocaine hydrochloride
- CAS No.：
- 36637-19-1
- 分 子 式：
-
C17H29ClN2O
- 分 子 量：
- 312.878
- 精确分子量：
- 312.19700
- PSA：
- 35.83000
- SDS：
- 查看
盐酸依替卡因 物化性质
- 沸点：
- 389.7ºC at 760 mmHg
- 闪点：
- 189.5ºC
盐酸依替卡因 毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EU5435000
- CHEMICAL NAME :
- 2',6'-Butyroxylidide, 2-(N-ethylpropylamino)-,
hydrochloride, (+-)-
- CAS REGISTRY NUMBER :
- 36637-19-1
- LAST UPDATED :
- 199109
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C17-H28-N2-O.Cl-H
- MOLECULAR WEIGHT :
- 312.93
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 64400 ug/kg
- TOXIC EFFECTS :
- Behavioral - anticonvulsant
Behavioral - somnolence (general depressed activity)
- REFERENCE :
- AACRAT Anesthesia and Analgesia (New York). (Elsevier Science Pub. Co.,
Inc., 52 Vanderbilt Ave., New York, NY 10017) V.36- 1957-
Volume(issue)/page/year: 60,385,1981
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 99 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 61,1829,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 6700 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc.,
2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
Volume(issue)/page/year: 61,1829,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intramuscular
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 58178 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New
York, NY 10003) V.1- 1981- Volume(issue)/page/year: 21,277,1990
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
37,13,1976