- 中文名称：
-
- 中文别名：
-
- 英文名称：
- (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one
- 英文别名：
- (7S)-10-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one;
Demecolcein;
(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one;
demecolceine;
(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one;
(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on;
N-Desacetyl-N-methylcolchiceine
- CAS No.：
- 518-11-6
- 分 子 式：
-
C20H23NO5
- 分 子 量：
- 357.40000
- 精确分子量：
- 357.15800
- PSA：
- 77.02000
- InChI：
- The Key: ATWWYGQDYGSWQA-AWEZNQCLSA-N3
- 分子结构式：
-
- SDS：
- 查看
物化性质
- 密度：
- 1.27g/cm3
- 沸点：
- 626.4ºC at 760 mmHg
- 闪点：
- 332.6ºC
- 折射率：
- 1.608
毒理性
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0600000
- CHEMICAL NAME :
- Colchiceine, N-deacetyl-N-methyl-
- CAS REGISTRY NUMBER :
- 518-11-6
- LAST UPDATED :
- 198712
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H23-N-O5
- MOLECULAR WEIGHT :
- 357.44
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New
York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year:
20,284,1957
