新生霉素纳,1476-53-5，生产厂家，价格-洛克化工网移动版

新生霉素纳

中文名称：: 新生霉素纳

中文别名：: 新生霉素纳;
新生霉素钠;
新生霉素;
氧乐果-D6

英文名称：: Benzamide,N-[7-[[3-O-(aminocarbonyl)-6-deoxy-5-C-methyl-4-O-methyl-a-L-lyxo-hexopyranosyl]oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl]-4-hydroxy-3-(3-methyl-2-buten-1-yl)-,sodium salt (1:1)

英文别名：: Novobiocin Sodium Salt;
NOVOBIOCIN SODIUM SALT;
Novobiocin sodium

CAS No.：: 1476-53-5

分子式：: C₃₁H₃₆N₂O₁₁.Na

分子量：: 634.61

精确分子量：: 634.21400

PSA：: 202.84000

MDL：: MFCD00066541

EINECS：: 216-023-6

BRN：: 3892910

InChI：: InChI=1/C31H36N2O11.Na/c1-14(2)7-8-16-13-17(9-11-19(16)34)27(37)33-21-22(35)18-10-12-20(15(3)24(18)42-28(21)38)41-29-23(36)25(43-30(32)39)26(40-6)31(4,5)44-29;/h7,9-13,23,25-26,29,34-36H,8H2,1-6H3,(H2,32,39)(H,33,37);/q;+1/p-1/t23-,25+,26-,29-;/m1./s13

危险品标志：

风险术语：: R36 R43

安全术语：: S26 S36/S37

分子结构式：

SDS：: 查看

新生霉素纳物化性质

密度：: 1.42g/cm3
熔点：: 215-220ºC
沸点：: 848.2ºC at 760mmHg
闪点：: 466.8ºC
存储条件/存储方法：: 密封、在2 ºC -8 ºC下保存
稳定性相关：: 如果遵照规格使用和储存则不会分解，未有已知危险反应，避免氧化物
其它信息：: 1.       性状：未确定。

2.       密度（g/mL,25/4℃）：未确定

3.       相对蒸汽密度（g/mL,空气=1）：未确定

4.       熔点（ºC）：215-220

5.       沸点（ºC,常压）：未确定

6.       沸点（ºC,5.2kPa）：未确定

7.       折射率：未确定

8.       闪点（ºC）：未确定

9.       比旋光度（º）：未确定

10.    自燃点或引燃温度（ºC）：未确定

11.    蒸气压（kPa,25ºC）：未确定

12.    饱和蒸气压（kPa,60ºC）：未确定

13.    燃烧热（KJ/mol）：未确定

14.    临界温度（ºC）：未确定

15.    临界压力（KPa）：未确定

16.    油水（辛醇/水）分配系数的对数值：未确定

17.    爆炸上限（%,V/V）：未确定

18.    爆炸下限（%,V/V）：未确定

19.    溶解性：未确定

新生霉素纳安全信息

危险类别码：: R43
安全标志：: S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
:
危险标志：: Xi: Irritant;

新生霉素纳毒理性

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RD5425000

CHEMICAL NAME :: Novobiocin, monosodium salt

CAS REGISTRY NUMBER :: 1476-53-5

LAST UPDATED :: 199512

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C31-H35-N2-O11.Na

MOLECULAR WEIGHT :: 634.67

WISWESSER LINE NOTATION :: T66 BOVJ DMVR DQ C2UY1&1& EQ IO- FT6OTJ B1 B1 CO1 DVZ EQ FO1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 385 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 962 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 262 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 395 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 407 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 12 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 28 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 3920 mg/kg/70D-I

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure)

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 1 gm/L

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 60,287,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1522 No. of Facilities: 15 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 88 (estimated) No. of Female Employees: 73 (estimated)

毒理学数据：: 急性毒性：大鼠口经LD50： 3500mg/kg；小鼠口经LD50：962mg/kg；小鼠腹经LD50：262mg/kg；大鼠静脉LD50：385mg/kg；大鼠皮下LD50：450mg/kg；小鼠皮下LD50：395mg/kg；天竺鼠腹经LD50：12mg/kg；天竺鼠皮下LD50：28mg/kg

生态数据：

对是水稍微有危害的不要让未稀释或大量的产品接触地下水、水道或者污水系统，若无政府许可，勿将材料排入周围环境。

新生霉素纳 MSDS

Section 1. Chemical Product and Company Identification
    Novobiocin Sodium        Catalog
    N1365, N1149
    Common Name/
    Number(s).
    Trade Name
    CAS#        1476-53-5
    Manufacturer
    RTECS        RD5425000
    SPECTRUM CHEMICAL MFG. CORP.
    TSCA        TSCA 8(b) inventory: No
    products were found.
    Commercial Name(s)        Not available.
    CI# Not available.
    Synonym        Not available.
    IN CASE OF EMERGENCY
    Not available.
    Chemical Name
    Chemical Family        Not available.        CALL (310) 516-8000
    C31H35N2NaO11
    Chemical Formula
    SPECTRUM CHEMICAL MFG. CORP.

Section 2.Composition and Information on Ingredients
    Exposure Limits
    TWA (mg/m3)        STEL (mg/m3) CEIL (mg/m3)
    Name        CAS #        % by Weight
    1) Novobiocin Sodium        1476-53-5        100
    Toxicological Data        Novobiocin Sodium:
    on Ingredients        ORAL (LD50):        Acute: 3500 mg/kg [Rat]. 962 mg/kg [Mouse].

Section 3. Hazards Identification
    Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation (lung irritant).
    Potential Chronic Health        CARCINOGENIC EFFECTS: Not available.
    MUTAGENIC EFFECTS: Not available.
    Effects
    TERATOGENIC EFFECTS: Not available.
    DEVELOPMENTAL TOXICITY: Not available.
    Repeated or prolonged exposure is not known to aggravate medical condition.
    Novobiocin Sodium

Section 4. First Aid Measures
    Eye Contact        Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
    keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
    Skin Contact        After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
    with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
    Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
    Wash contaminated clothing before reusing.
    Serious Skin Contact        Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek immediate
    medical attention.
    Inhalation        Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
    Serious Inhalation        Not available.
    Ingestion        Do not induce vomiting. Examine the lips and mouth to ascertain whether the tissues are damaged, a possible
    indication that the toxic material was ingested; the absence of such signs, however, is not conclusive. Loosen
    tight clothing such as a collar, tie, belt or waistband. If the victim is not breathing, perform mouth-to-mouth
    resuscitation. Seek immediate medical attention.
    Serious Ingestion        Not available.

Section 5. Fire and Explosion Data
    Flammability of the Product May be combustible at high temperature.
    Auto-Ignition Temperature Not available.
    Flash Points        Not available.
    Flammable Limits        Not available.
    Products of Combustion        These products are carbon oxides (CO, CO2), nitrogen oxides (NO, NO2...). Some metallic oxides.
    Fire Hazards in Presence of Not available.
    Various Substances
    Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
    of Various Substances        Risks of explosion of the product in presence of static discharge: Not available.
    Fire Fighting Media        SMALL FIRE: Use DRY chemical powder.
    and Instructions        LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
    Special Remarks on        Not available.
    Fire Hazards
    Special Remarks on Explosion Not available.
    Hazards

Section 6. Accidental Release Measures
    Small Spill        Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
    spreading water on the contaminated surface and dispose of according to local and regional authority
    requirements.
    Large Spill        Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
    on the contaminated surface and allow to evacuate through the sanitary system.
    Novobiocin Sodium

Section 7. Handling and Storage
    Precautions        Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
    residue under a fume hood. Ground all equipment containing material. Do not ingest. Do not breathe dust.
    Wear suitable protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If
    ingested, seek medical advice immediately and show the container or the label. Avoid contact with skin and eyes
    Storage        Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
    closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
    and away from strong oxidizing agents.

Section 8. Exposure Controls/Personal Protection
    Engineering Controls        Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
    recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
    airborne contaminants below the exposure limit.
    Personal Protection        Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
    Gloves.
    Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
    a Large Spill        to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
    BEFORE handling this product.
    Exposure Limits        Not available.

Section 9. Physical and Chemical Properties
    Physical state and appearance Solid.        Odor        Not available.
    Taste        Not available.
    634.62 g/mole
    Molecular Weight
    Color        Not available.
    pH (1% soln/water)        Not available.
    Boiling Point        Not available.
    Melting Point        Decomposes.
    Critical Temperature        Not available.
    Specific Gravity        Not available.
    Not applicable.
    Vapor Pressure
    Vapor Density        Not available.
    Volatility        Not available.
    Odor Threshold        Not available.
    Water/Oil Dist. Coeff.        Not available.
    Not available.
    Ionicity (in Water)
    Dispersion Properties        See solubility in water.
    Partially soluble in cold water.
    Solubility

Section 10. Stability and Reactivity Data
    The product is stable.
    Stability
    Instability Temperature        Not available.
    Not available.
    Conditions of Instability
    Incompatibility with various Not available.
    substances
    Novobiocin Sodium
    Corrosivity        Non-corrosive in presence of glass.
    Special Remarks on        Not available.
    Reactivity
    Special Remarks on        Not available.
    Corrosivity
    Polymerization        No.

Section 11. Toxicological Information
    Routes of Entry        Eye contact. Inhalation. Ingestion.
    Toxicity to Animals        Acute oral toxicity (LD50): 962 mg/kg [Mouse].
    Chronic Effects on Humans Not available.
    Other Toxic Effects on        Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).
    Humans
    Special Remarks on        Not available.
    Toxicity to Animals
    Special Remarks on        Not available.
    Chronic Effects on Humans
    Special Remarks on other        Not available.
    Toxic Effects on Humans

Section 12. Ecological Information
    Ecotoxicity        Not available.
    BOD5 and COD        Not available.
    Products of Biodegradation        Possibly hazardous short term degradation products are not likely. However, long term degradation products may
    arise.
    Toxicity of the Products        The products of degradation are more toxic.
    of Biodegradation
    Special Remarks on the        Not available.
    Products of Biodegradation

Section 13. Disposal Considerations
Waste Disposal

Section 14. Transport Information
    DOT Classification        Not a DOT controlled material (United States).
    Identification        Not applicable.
    Special Provisions for        Not applicable.
    Transport
    Novobiocin Sodium
    DOT (Pictograms)

Section 15. Other Regulatory Information and Pictograms
    No products were found.
    Federal and State
    Regulations
    California
    Proposition 65
    Warnings
    Other Regulations        EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
    WHMIS (Canada) Not controlled under WHMIS (Canada).
    Other Classifications
    DSCL (EEC)        R36/37/38- Irritating to eyes,
    respiratory system and skin.
    Health Hazard
    HMIS (U.S.A.)        2 National Fire Protection
    1 Flammability
    1 Association (U.S.A.)
    Fire Hazard
    2 0 Reactivity
    Health
    Reactivity
    0
    Specific hazard
    Personal Protection
    E
    WHMIS (Canada)
    (Pictograms)
    DSCL (Europe)
    (Pictograms)
    TDG (Canada)
    (Pictograms)
    ADR (Europe)
    (Pictograms)
    Protective Equipment
    Gloves.
    Lab coat.
    Dust respirator. Be sure to use an
    approved/certified respirator or
    equivalent.
    Novobiocin Sodium

SECTION 16 - ADDITIONAL INFORMATION
N/A

新生霉素纳分子结构与计算化学数据

分子结构数据

1、摩尔折射率：无可用的

2、摩尔体积（cm³/mol）：无可用的

3、等张比容（90.2K）：无可用的

4、表面张力（dyne/cm）：无可用的

5、介电常数：无可用的

6、极化率（10^-24cm³）：无可用的

7、单一同位素质量：634.213855 Da

8、标称质量：634 Da

9、平均质量：634.6062 Da

计算化学数据

1、氢键供体数量：4

2、氢键受体数量：11

3、可旋转化学键数量：9

4、互变异构体数量：14

5、拓扑分子极性表面积（TPSA）：199

6、重原子数量：45

7、表面电荷：0

8、复杂度：1160

9、同位素原子数量：0

10、确定原子立构中心数量：4

11、不确定原子立构中心数量：0

12、确定化学键立构中心数量：0

13、不确定化学键立构中心数量：0

14、共价键单元数量：2

新生霉素纳下游产品

新生霉素 novobiocic acid