制备方法

1.将28kg工业苯酚、40kg工业水杨酸投入干燥的反应釜内，加热熔融，严格控制温度(130±2)℃。搅拌下缓缓滴入三氯化磷16kg进行反应，加毕，仍保持(130±2)℃，搅拌4h。排尽反应生成的氯化氢后，趁热用两倍的65℃热水洗涤，静置40min，分去水层后，再洗涤1次。用5%的碳酸氢钠溶液中和至pH为8，再用65℃的热水洗至pH值为7。静置，分去水层，在油层中加入约1倍的蒸馏水搅拌均匀、冷却、结晶、活性炭脱色，即得成品。

合成制备方法

1.将28kg工业苯酚、40kg工业水杨酸投入干燥的反应釜内，加热熔融，严格控制温度(130±2)℃。搅拌下缓缓滴入三氯化磷16kg进行反应，加毕，仍保持(130±2)℃，搅拌4h。排尽反应生成的氯化氢后，趁热用两倍的65℃热水洗涤，静置40min，分去水层后，再洗涤1次。用5%的碳酸氢钠溶液中和至pH为8，再用65℃的热水洗至pH值为7。静置，分去水层，在油层中加入约1倍的蒸馏水搅拌均匀、冷却、结晶、活性炭脱色，即得成品。

用途简介

本品用作有机合成中间体。

用途

1.用作塑料制品的紫外线吸收剂、增塑剂、防腐剂，用于药物合成、配制香精等。

海关代码：

2918230000

WGK_Germany：

2
德国有关水污染物质的分类清单

危险类别码：

R36/37/38

安全说明：

S26-S36-S24/25

RTECS号：

VO6125000

安全标志：

S26:万一接触眼睛，立即使用大量清水冲洗并送医诊治。
S36:穿戴合适的防护服装。

危险标志：

Xi

CHEMICAL IDENTIFICATION

RTECS NUMBER :

VO6125000

CHEMICAL NAME :

Salicylic acid, phenyl ester

CAS REGISTRY NUMBER :

118-55-8

BEILSTEIN REFERENCE NO. :

0393969

LAST UPDATED :

199710

DATA ITEMS CITED :

11

MOLECULAR FORMULA :

C13-H10-O3

MOLECULAR WEIGHT :

214.23

WISWESSER LINE NOTATION :

QR BVOR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 14,837,1976

TYPE OF TEST :

LD - Lethal dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

>500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,149,1954

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rabbit

DOSE/DURATION :

3 gm/kg

TOXIC EFFECTS :

Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :

RMSRA6 Revue Medicale de la Suisse Romande. (Societe Medicale de La Suisse Romande, 2 rue Bellefontaine, 1003 Lausanne, Switzerland) V.1- 1881- Volume(issue)/page/year: 15,561,1895 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

600 mg/kg

SEX/DURATION :

female 7-12 day(s) after conception

TOXIC EFFECTS :

Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth)

REFERENCE :

OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1200 mg/kg

SEX/DURATION :

female 7-9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :

OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

600 mg/kg

SEX/DURATION :

female 7-9 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :

OCMJAJ Osaka City Medical Journal. (Osaka City Medical Center, 1-4-54, Asahi-machi, Abeno-ku, Osaka 545, Japan) V.1- 1954- Volume(issue)/page/year: 12,23,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80479 No. of Facilities: 241 (estimated) No. of Industries: 3 No. of Occupations: 8 No. of Employees: 2943 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80479 No. of Facilities: 471 (estimated) No. of Industries: 4 No. of Occupations: 11 No. of Employees: 5712 (estimated) No. of Female Employees: 2297 (estimated)

毒理学数据：

低毒，大鼠经口LD50：1500mg/kg，可用于接触食品的丙烯酸树脂制品中。

生态数据：

对水有稍微的危害。

中国海关编码：2918230000

概述：

2918230000 水杨酸其他酯. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

摘要/Summary：

2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

分子结构数据

1、   摩尔折射率：59.77

2、   摩尔体积（cm³/mol）：171.2

3、   等张比容（90.2K）：459.6

4、   表面张力（dyne/cm）：51.8

5、   极化率（10-24cm3）：23.69